Hantavirus infection in patients with fever of unknown origin and in small mammals in the Baikal region

Background. Hantavirus infections are one of the most important zoonotic diseases in the Russian Federation. However, the pathogenicity of Hantaviruses circulating in Siberia is still unknown. The aim of the study was to assess the incidence of Hantavirus infection in patients with fever of unknown...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	N. A. Bolotova, M. A. Khasnatinov, A. V. Lyapunov, E. L. Manzarova, I. S. Solovarov, L. N. Yashina, R. .. Yanagihara, G. A. Danchinova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2017
Materias:	hemorrhagic fever with renal syndrome hantavirus hantavirus antigen hantavirus antibodies Science Q
Acceso en línea:	https://doaj.org/article/aae45d5231a346bb8666f52ad62ad74b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:aae45d5231a346bb8666f52ad62ad74b
record_format	dspace
spelling	oai:doaj.org-article:aae45d5231a346bb8666f52ad62ad74b2021-11-23T06:14:38ZHantavirus infection in patients with fever of unknown origin and in small mammals in the Baikal region2541-94202587-959610.12737/article_59e8bd3a7447f0.81371234https://doaj.org/article/aae45d5231a346bb8666f52ad62ad74b2017-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/452https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. Hantavirus infections are one of the most important zoonotic diseases in the Russian Federation. However, the pathogenicity of Hantaviruses circulating in Siberia is still unknown. The aim of the study was to assess the incidence of Hantavirus infection in patients with fever of unknown origin from Irkutsk region and adjacent territories. Materials and methods. Serum samples collected in 2016 from individuals with symptoms of health deterioration were screened by ELISA to investigate possible Hantavirus infection, in addition to tick-borne infections. Depending on date of tick bite specific immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies to tick-borne encephalitis, borreliosis and Hantavirus were tested by ELISA or screened by PCR for tick-borne encephalitis, borreliosis, human granulocytic anaplasmosis and monocytic erlychiosis RNA/DNA. Results. Out of 92 serum samples, 6.5 % were positive for hantavirus-specific antibodies, which is at least twice higher than the seroprevalence among healthy people in the Irkutsk region. IgM and IgM+IgG antibodies were found in 5.4 % of cases, while IgG antibodies - in 1.1 % of cases. The clinical symptoms among sero-positive patients were fever, skin lesion, fatigue syndrome, headache and lymphadenitis. IgM antibodies to borreliosis were found in two hantavirus sero-positive cases. Lung tissues from small mammals captured in 2016 were screened by ELISA for the presence of Hantavirus antigen. Hantaviral antigen was detected in 6.3 % of 48 samples. Conclusions. Thus, present and previous studies demonstrate existence of natural foci of Hantavirus infections in addition to tick-born infections in the territory of the Irkutsk region.N. A. BolotovaM. A. KhasnatinovA. V. LyapunovE. L. ManzarovaI. S. SolovarovL. N. YashinaR. .. YanagiharaG. A. DanchinovaScientific Сentre for Family Health and Human Reproduction Problemsarticlehemorrhagic fever with renal syndromehantavirushantavirus antigenhantavirus antibodiesScienceQRUActa Biomedica Scientifica, Vol 2, Iss 5(1), Pp 174-179 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	hemorrhagic fever with renal syndrome hantavirus hantavirus antigen hantavirus antibodies Science Q
spellingShingle	hemorrhagic fever with renal syndrome hantavirus hantavirus antigen hantavirus antibodies Science Q N. A. Bolotova M. A. Khasnatinov A. V. Lyapunov E. L. Manzarova I. S. Solovarov L. N. Yashina R. .. Yanagihara G. A. Danchinova Hantavirus infection in patients with fever of unknown origin and in small mammals in the Baikal region
description	Background. Hantavirus infections are one of the most important zoonotic diseases in the Russian Federation. However, the pathogenicity of Hantaviruses circulating in Siberia is still unknown. The aim of the study was to assess the incidence of Hantavirus infection in patients with fever of unknown origin from Irkutsk region and adjacent territories. Materials and methods. Serum samples collected in 2016 from individuals with symptoms of health deterioration were screened by ELISA to investigate possible Hantavirus infection, in addition to tick-borne infections. Depending on date of tick bite specific immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies to tick-borne encephalitis, borreliosis and Hantavirus were tested by ELISA or screened by PCR for tick-borne encephalitis, borreliosis, human granulocytic anaplasmosis and monocytic erlychiosis RNA/DNA. Results. Out of 92 serum samples, 6.5 % were positive for hantavirus-specific antibodies, which is at least twice higher than the seroprevalence among healthy people in the Irkutsk region. IgM and IgM+IgG antibodies were found in 5.4 % of cases, while IgG antibodies - in 1.1 % of cases. The clinical symptoms among sero-positive patients were fever, skin lesion, fatigue syndrome, headache and lymphadenitis. IgM antibodies to borreliosis were found in two hantavirus sero-positive cases. Lung tissues from small mammals captured in 2016 were screened by ELISA for the presence of Hantavirus antigen. Hantaviral antigen was detected in 6.3 % of 48 samples. Conclusions. Thus, present and previous studies demonstrate existence of natural foci of Hantavirus infections in addition to tick-born infections in the territory of the Irkutsk region.
format	article
author	N. A. Bolotova M. A. Khasnatinov A. V. Lyapunov E. L. Manzarova I. S. Solovarov L. N. Yashina R. .. Yanagihara G. A. Danchinova
author_facet	N. A. Bolotova M. A. Khasnatinov A. V. Lyapunov E. L. Manzarova I. S. Solovarov L. N. Yashina R. .. Yanagihara G. A. Danchinova
author_sort	N. A. Bolotova
title	Hantavirus infection in patients with fever of unknown origin and in small mammals in the Baikal region
title_short	Hantavirus infection in patients with fever of unknown origin and in small mammals in the Baikal region
title_full	Hantavirus infection in patients with fever of unknown origin and in small mammals in the Baikal region
title_fullStr	Hantavirus infection in patients with fever of unknown origin and in small mammals in the Baikal region
title_full_unstemmed	Hantavirus infection in patients with fever of unknown origin and in small mammals in the Baikal region
title_sort	hantavirus infection in patients with fever of unknown origin and in small mammals in the baikal region
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2017
url	https://doaj.org/article/aae45d5231a346bb8666f52ad62ad74b
work_keys_str_mv	AT nabolotova hantavirusinfectioninpatientswithfeverofunknownoriginandinsmallmammalsinthebaikalregion AT makhasnatinov hantavirusinfectioninpatientswithfeverofunknownoriginandinsmallmammalsinthebaikalregion AT avlyapunov hantavirusinfectioninpatientswithfeverofunknownoriginandinsmallmammalsinthebaikalregion AT elmanzarova hantavirusinfectioninpatientswithfeverofunknownoriginandinsmallmammalsinthebaikalregion AT issolovarov hantavirusinfectioninpatientswithfeverofunknownoriginandinsmallmammalsinthebaikalregion AT lnyashina hantavirusinfectioninpatientswithfeverofunknownoriginandinsmallmammalsinthebaikalregion AT ryanagihara hantavirusinfectioninpatientswithfeverofunknownoriginandinsmallmammalsinthebaikalregion AT gadanchinova hantavirusinfectioninpatientswithfeverofunknownoriginandinsmallmammalsinthebaikalregion
_version_	1718417026374959104

Hantavirus infection in patients with fever of unknown origin and in small mammals in the Baikal region

Ejemplares similares