Neuronal signals regulate obesity induced β-cell proliferation by FoxM1 dependent mechanism
Neuronal signals, in particular those transmitted via the vagal nerve, regulate both β-cell function and proliferation. Here, Yamamoto et al. show that the forkhead box M1 pathway is required for vagal signal-mediated induction of β-cell proliferation during obesity.
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Nature Portfolio
2017
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oai:doaj.org-article:aaeb1c2dd7e541f790c32e689f9722af2021-12-02T15:39:02ZNeuronal signals regulate obesity induced β-cell proliferation by FoxM1 dependent mechanism10.1038/s41467-017-01869-72041-1723https://doaj.org/article/aaeb1c2dd7e541f790c32e689f9722af2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01869-7https://doaj.org/toc/2041-1723Neuronal signals, in particular those transmitted via the vagal nerve, regulate both β-cell function and proliferation. Here, Yamamoto et al. show that the forkhead box M1 pathway is required for vagal signal-mediated induction of β-cell proliferation during obesity.Junpei YamamotoJunta ImaiTomohito IzumiHironori TakahashiYohei KawanaKei TakahashiShinjiro KodamaKeizo KanekoJunhong GaoKenji UnoShojiro SawadaTomoichiro AsanoVladimir V. KalinichenkoEtsuo A. SusakiMakoto KanzakiHiroki R. UedaYasushi IshigakiTetsuya YamadaHideki KatagiriNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Junpei Yamamoto Junta Imai Tomohito Izumi Hironori Takahashi Yohei Kawana Kei Takahashi Shinjiro Kodama Keizo Kaneko Junhong Gao Kenji Uno Shojiro Sawada Tomoichiro Asano Vladimir V. Kalinichenko Etsuo A. Susaki Makoto Kanzaki Hiroki R. Ueda Yasushi Ishigaki Tetsuya Yamada Hideki Katagiri Neuronal signals regulate obesity induced β-cell proliferation by FoxM1 dependent mechanism |
| description |
Neuronal signals, in particular those transmitted via the vagal nerve, regulate both β-cell function and proliferation. Here, Yamamoto et al. show that the forkhead box M1 pathway is required for vagal signal-mediated induction of β-cell proliferation during obesity. |
| format |
article |
| author |
Junpei Yamamoto Junta Imai Tomohito Izumi Hironori Takahashi Yohei Kawana Kei Takahashi Shinjiro Kodama Keizo Kaneko Junhong Gao Kenji Uno Shojiro Sawada Tomoichiro Asano Vladimir V. Kalinichenko Etsuo A. Susaki Makoto Kanzaki Hiroki R. Ueda Yasushi Ishigaki Tetsuya Yamada Hideki Katagiri |
| author_facet |
Junpei Yamamoto Junta Imai Tomohito Izumi Hironori Takahashi Yohei Kawana Kei Takahashi Shinjiro Kodama Keizo Kaneko Junhong Gao Kenji Uno Shojiro Sawada Tomoichiro Asano Vladimir V. Kalinichenko Etsuo A. Susaki Makoto Kanzaki Hiroki R. Ueda Yasushi Ishigaki Tetsuya Yamada Hideki Katagiri |
| author_sort |
Junpei Yamamoto |
| title |
Neuronal signals regulate obesity induced β-cell proliferation by FoxM1 dependent mechanism |
| title_short |
Neuronal signals regulate obesity induced β-cell proliferation by FoxM1 dependent mechanism |
| title_full |
Neuronal signals regulate obesity induced β-cell proliferation by FoxM1 dependent mechanism |
| title_fullStr |
Neuronal signals regulate obesity induced β-cell proliferation by FoxM1 dependent mechanism |
| title_full_unstemmed |
Neuronal signals regulate obesity induced β-cell proliferation by FoxM1 dependent mechanism |
| title_sort |
neuronal signals regulate obesity induced β-cell proliferation by foxm1 dependent mechanism |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/aaeb1c2dd7e541f790c32e689f9722af |
| work_keys_str_mv |
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| _version_ |
1718386008428380160 |