Actin crosslinker competition and sorting drive emergent GUV size-dependent actin network architecture

By encapsulating proteins in giant unilamellar vesicles, Bashirzadeh et al find that actin crosslinkers, α-actinin and fascin, can self-assemble with actin into complex structures that depend on the degree of confinement. Further analysis and modeling show that α-actinin and fascin sort to separate...

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Autores principales:	Yashar Bashirzadeh, Steven A. Redford, Chatipat Lorpaiboon, Alessandro Groaz, Hossein Moghimianavval, Thomas Litschel, Petra Schwille, Glen M. Hocky, Aaron R. Dinner, Allen P. Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/aaed8fb477af48c18e68c17570b33fa1
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spelling	oai:doaj.org-article:aaed8fb477af48c18e68c17570b33fa12021-12-02T17:37:39ZActin crosslinker competition and sorting drive emergent GUV size-dependent actin network architecture10.1038/s42003-021-02653-62399-3642https://doaj.org/article/aaed8fb477af48c18e68c17570b33fa12021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02653-6https://doaj.org/toc/2399-3642By encapsulating proteins in giant unilamellar vesicles, Bashirzadeh et al find that actin crosslinkers, α-actinin and fascin, can self-assemble with actin into complex structures that depend on the degree of confinement. Further analysis and modeling show that α-actinin and fascin sort to separate domains of these structures. These insights may be generalizable to other biopolymer networks containing crosslinkers.Yashar BashirzadehSteven A. RedfordChatipat LorpaiboonAlessandro GroazHossein MoghimianavvalThomas LitschelPetra SchwilleGlen M. HockyAaron R. DinnerAllen P. LiuNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Yashar Bashirzadeh Steven A. Redford Chatipat Lorpaiboon Alessandro Groaz Hossein Moghimianavval Thomas Litschel Petra Schwille Glen M. Hocky Aaron R. Dinner Allen P. Liu Actin crosslinker competition and sorting drive emergent GUV size-dependent actin network architecture
description	By encapsulating proteins in giant unilamellar vesicles, Bashirzadeh et al find that actin crosslinkers, α-actinin and fascin, can self-assemble with actin into complex structures that depend on the degree of confinement. Further analysis and modeling show that α-actinin and fascin sort to separate domains of these structures. These insights may be generalizable to other biopolymer networks containing crosslinkers.
format	article
author	Yashar Bashirzadeh Steven A. Redford Chatipat Lorpaiboon Alessandro Groaz Hossein Moghimianavval Thomas Litschel Petra Schwille Glen M. Hocky Aaron R. Dinner Allen P. Liu
author_facet	Yashar Bashirzadeh Steven A. Redford Chatipat Lorpaiboon Alessandro Groaz Hossein Moghimianavval Thomas Litschel Petra Schwille Glen M. Hocky Aaron R. Dinner Allen P. Liu
author_sort	Yashar Bashirzadeh
title	Actin crosslinker competition and sorting drive emergent GUV size-dependent actin network architecture
title_short	Actin crosslinker competition and sorting drive emergent GUV size-dependent actin network architecture
title_full	Actin crosslinker competition and sorting drive emergent GUV size-dependent actin network architecture
title_fullStr	Actin crosslinker competition and sorting drive emergent GUV size-dependent actin network architecture
title_full_unstemmed	Actin crosslinker competition and sorting drive emergent GUV size-dependent actin network architecture
title_sort	actin crosslinker competition and sorting drive emergent guv size-dependent actin network architecture
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/aaed8fb477af48c18e68c17570b33fa1
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Actin crosslinker competition and sorting drive emergent GUV size-dependent actin network architecture

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