Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes

Immunoproteasome selective inhibitors might lead to less toxic drugs for treatment of multiple myeloma and graft rejection. Here, the authors develop immunoproteasome specific asparagine-ethylenediamine (AsnEDA)-based inhibitory compounds, demonstrate their efficacy and present the AsnEDA bound immu...

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Autores principales:	Ruda de Luna Almeida Santos, Lin Bai, Pradeep K. Singh, Naoka Murakami, Hao Fan, Wenhu Zhan, Yingrong Zhu, Xiuju Jiang, Kaiming Zhang, Jean Pierre Assker, Carl F. Nathan, Huilin Li, Jamil Azzi, Gang Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/aaef590b4c434dd3a24ff936b3177a69
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spelling	oai:doaj.org-article:aaef590b4c434dd3a24ff936b3177a692021-12-02T14:42:00ZStructure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes10.1038/s41467-017-01760-52041-1723https://doaj.org/article/aaef590b4c434dd3a24ff936b3177a692017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01760-5https://doaj.org/toc/2041-1723Immunoproteasome selective inhibitors might lead to less toxic drugs for treatment of multiple myeloma and graft rejection. Here, the authors develop immunoproteasome specific asparagine-ethylenediamine (AsnEDA)-based inhibitory compounds, demonstrate their efficacy and present the AsnEDA bound immunoproteasome cryo-EM structure.Ruda de Luna Almeida SantosLin BaiPradeep K. SinghNaoka MurakamiHao FanWenhu ZhanYingrong ZhuXiuju JiangKaiming ZhangJean Pierre AsskerCarl F. NathanHuilin LiJamil AzziGang LinNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ruda de Luna Almeida Santos Lin Bai Pradeep K. Singh Naoka Murakami Hao Fan Wenhu Zhan Yingrong Zhu Xiuju Jiang Kaiming Zhang Jean Pierre Assker Carl F. Nathan Huilin Li Jamil Azzi Gang Lin Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes
description	Immunoproteasome selective inhibitors might lead to less toxic drugs for treatment of multiple myeloma and graft rejection. Here, the authors develop immunoproteasome specific asparagine-ethylenediamine (AsnEDA)-based inhibitory compounds, demonstrate their efficacy and present the AsnEDA bound immunoproteasome cryo-EM structure.
format	article
author	Ruda de Luna Almeida Santos Lin Bai Pradeep K. Singh Naoka Murakami Hao Fan Wenhu Zhan Yingrong Zhu Xiuju Jiang Kaiming Zhang Jean Pierre Assker Carl F. Nathan Huilin Li Jamil Azzi Gang Lin
author_facet	Ruda de Luna Almeida Santos Lin Bai Pradeep K. Singh Naoka Murakami Hao Fan Wenhu Zhan Yingrong Zhu Xiuju Jiang Kaiming Zhang Jean Pierre Assker Carl F. Nathan Huilin Li Jamil Azzi Gang Lin
author_sort	Ruda de Luna Almeida Santos
title	Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes
title_short	Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes
title_full	Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes
title_fullStr	Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes
title_full_unstemmed	Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes
title_sort	structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/aaef590b4c434dd3a24ff936b3177a69
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Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes

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