Monitoring cytosolic H2O2 fluctuations arising from altered plasma membrane gradients or from mitochondrial activity

Monitoring cytosolic H2O2 fluctuations arising from altered plasma membrane gradients or from mitochondrial activity

Reliable methods of measuring intracellular H2O2 fluctuations are necessary to advance redox biology. Here the authors design a H2O2 sensor based on the fission yeast peroxiredoxin Tpx1 to sense nanomolar fluctuations of intracellular H2O2 in response to genetic and environmental perturbations.

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Autores principales: Mercè Carmona, Laura de Cubas, Eric Bautista, Marta Moral-Blanch, Iria Medraño-Fernández, Roberto Sitia, Susanna Boronat, José Ayté, Elena Hidalgo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/aafcb8e611bf4afab90ca09a171dc392
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spelling oai:doaj.org-article:aafcb8e611bf4afab90ca09a171dc3922021-12-02T14:38:39ZMonitoring cytosolic H2O2 fluctuations arising from altered plasma membrane gradients or from mitochondrial activity10.1038/s41467-019-12475-02041-1723https://doaj.org/article/aafcb8e611bf4afab90ca09a171dc3922019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12475-0https://doaj.org/toc/2041-1723Reliable methods of measuring intracellular H2O2 fluctuations are necessary to advance redox biology. Here the authors design a H2O2 sensor based on the fission yeast peroxiredoxin Tpx1 to sense nanomolar fluctuations of intracellular H2O2 in response to genetic and environmental perturbations.Mercè CarmonaLaura de CubasEric BautistaMarta Moral-BlanchIria Medraño-FernándezRoberto SitiaSusanna BoronatJosé AytéElena HidalgoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Mercè Carmona
Laura de Cubas
Eric Bautista
Marta Moral-Blanch
Iria Medraño-Fernández
Roberto Sitia
Susanna Boronat
José Ayté
Elena Hidalgo
Monitoring cytosolic H2O2 fluctuations arising from altered plasma membrane gradients or from mitochondrial activity
description Reliable methods of measuring intracellular H2O2 fluctuations are necessary to advance redox biology. Here the authors design a H2O2 sensor based on the fission yeast peroxiredoxin Tpx1 to sense nanomolar fluctuations of intracellular H2O2 in response to genetic and environmental perturbations.
format article
author Mercè Carmona
Laura de Cubas
Eric Bautista
Marta Moral-Blanch
Iria Medraño-Fernández
Roberto Sitia
Susanna Boronat
José Ayté
Elena Hidalgo
author_facet Mercè Carmona
Laura de Cubas
Eric Bautista
Marta Moral-Blanch
Iria Medraño-Fernández
Roberto Sitia
Susanna Boronat
José Ayté
Elena Hidalgo
author_sort Mercè Carmona
title Monitoring cytosolic H2O2 fluctuations arising from altered plasma membrane gradients or from mitochondrial activity
title_short Monitoring cytosolic H2O2 fluctuations arising from altered plasma membrane gradients or from mitochondrial activity
title_full Monitoring cytosolic H2O2 fluctuations arising from altered plasma membrane gradients or from mitochondrial activity
title_fullStr Monitoring cytosolic H2O2 fluctuations arising from altered plasma membrane gradients or from mitochondrial activity
title_full_unstemmed Monitoring cytosolic H2O2 fluctuations arising from altered plasma membrane gradients or from mitochondrial activity
title_sort monitoring cytosolic h2o2 fluctuations arising from altered plasma membrane gradients or from mitochondrial activity
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/aafcb8e611bf4afab90ca09a171dc392
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