Switches, excitable responses and oscillations in the Ring1B/Bmi1 ubiquitination system.
In an active, self-ubiquitinated state, the Ring1B ligase monoubiquitinates histone H2A playing a critical role in Polycomb-mediated gene silencing. Following ubiquitination by external ligases, Ring1B is targeted for proteosomal degradation. Using biochemical data and computational modeling, we sho...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Public Library of Science (PLoS)
2011
|
| Subjects: | |
| Online Access: | https://doaj.org/article/aafeecf9ac4742dd92a9142aa127ff1f |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|