BMP-7 does not protect against bleomycin-induced lung or skin fibrosis.

Bone morphogenic protein (BMP)-7 is a member of the BMP family which are structurally and functionally related, and part of the TGFbeta super family of growth factors. BMP-7 has been reported to inhibit renal fibrosis and TGFbeta1-induced epithelial-mesenchymal transition (EMT), in part through nega...

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Autores principales:	Lynne A Murray, Tillie L Hackett, Stephanie M Warner, Furquan Shaheen, Rochelle L Argentieri, Paul Dudas, Francis X Farrell, Darryl A Knight
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/aaff4464c87b4da18f8a904246b05236
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spelling	oai:doaj.org-article:aaff4464c87b4da18f8a904246b052362021-11-25T06:18:00ZBMP-7 does not protect against bleomycin-induced lung or skin fibrosis.1932-620310.1371/journal.pone.0004039https://doaj.org/article/aaff4464c87b4da18f8a904246b052362008-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19112509/?tool=EBIhttps://doaj.org/toc/1932-6203Bone morphogenic protein (BMP)-7 is a member of the BMP family which are structurally and functionally related, and part of the TGFbeta super family of growth factors. BMP-7 has been reported to inhibit renal fibrosis and TGFbeta1-induced epithelial-mesenchymal transition (EMT), in part through negative interactions with TGFbeta1 induced Smad 2/3 activation. We utilized in vivo bleomycin-induced fibrosis models in the skin and lung to determine the potential therapeutic effect of BMP-7. We then determined the effect of BMP-7 on TGFbeta1-induced EMT in lung epithelial cells and collagen production by human lung fibroblasts. We show that BMP-7 did not affect bleomycin-induced fibrosis in either the lung or skin in vivo; had no effect on expression of pro-fibrotic genes by human lung fibroblasts, either at rest or following exposure to TGFbeta1; and did not modulate TGFbeta1-induced EMT in human lung epithelial cells. Taken together our data indicates that BMP-7 has no anti-fibrotic effect in lung or skin fibrosis either in vivo or in vitro. This suggests that the therapeutic options for BMP-7 may be confined to the renal compartment.Lynne A MurrayTillie L HackettStephanie M WarnerFurquan ShaheenRochelle L ArgentieriPaul DudasFrancis X FarrellDarryl A KnightPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 12, p e4039 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lynne A Murray Tillie L Hackett Stephanie M Warner Furquan Shaheen Rochelle L Argentieri Paul Dudas Francis X Farrell Darryl A Knight BMP-7 does not protect against bleomycin-induced lung or skin fibrosis.
description	Bone morphogenic protein (BMP)-7 is a member of the BMP family which are structurally and functionally related, and part of the TGFbeta super family of growth factors. BMP-7 has been reported to inhibit renal fibrosis and TGFbeta1-induced epithelial-mesenchymal transition (EMT), in part through negative interactions with TGFbeta1 induced Smad 2/3 activation. We utilized in vivo bleomycin-induced fibrosis models in the skin and lung to determine the potential therapeutic effect of BMP-7. We then determined the effect of BMP-7 on TGFbeta1-induced EMT in lung epithelial cells and collagen production by human lung fibroblasts. We show that BMP-7 did not affect bleomycin-induced fibrosis in either the lung or skin in vivo; had no effect on expression of pro-fibrotic genes by human lung fibroblasts, either at rest or following exposure to TGFbeta1; and did not modulate TGFbeta1-induced EMT in human lung epithelial cells. Taken together our data indicates that BMP-7 has no anti-fibrotic effect in lung or skin fibrosis either in vivo or in vitro. This suggests that the therapeutic options for BMP-7 may be confined to the renal compartment.
format	article
author	Lynne A Murray Tillie L Hackett Stephanie M Warner Furquan Shaheen Rochelle L Argentieri Paul Dudas Francis X Farrell Darryl A Knight
author_facet	Lynne A Murray Tillie L Hackett Stephanie M Warner Furquan Shaheen Rochelle L Argentieri Paul Dudas Francis X Farrell Darryl A Knight
author_sort	Lynne A Murray
title	BMP-7 does not protect against bleomycin-induced lung or skin fibrosis.
title_short	BMP-7 does not protect against bleomycin-induced lung or skin fibrosis.
title_full	BMP-7 does not protect against bleomycin-induced lung or skin fibrosis.
title_fullStr	BMP-7 does not protect against bleomycin-induced lung or skin fibrosis.
title_full_unstemmed	BMP-7 does not protect against bleomycin-induced lung or skin fibrosis.
title_sort	bmp-7 does not protect against bleomycin-induced lung or skin fibrosis.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/aaff4464c87b4da18f8a904246b05236
work_keys_str_mv	AT lynneamurray bmp7doesnotprotectagainstbleomycininducedlungorskinfibrosis AT tillielhackett bmp7doesnotprotectagainstbleomycininducedlungorskinfibrosis AT stephaniemwarner bmp7doesnotprotectagainstbleomycininducedlungorskinfibrosis AT furquanshaheen bmp7doesnotprotectagainstbleomycininducedlungorskinfibrosis AT rochellelargentieri bmp7doesnotprotectagainstbleomycininducedlungorskinfibrosis AT pauldudas bmp7doesnotprotectagainstbleomycininducedlungorskinfibrosis AT francisxfarrell bmp7doesnotprotectagainstbleomycininducedlungorskinfibrosis AT darrylaknight bmp7doesnotprotectagainstbleomycininducedlungorskinfibrosis
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BMP-7 does not protect against bleomycin-induced lung or skin fibrosis.

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