A small molecule HIF-1α stabilizer that accelerates diabetic wound healing
Impaired wound healing is a serious complication in diabetic patients, and is associated with reduced HIF1α stability. Here, the authors design a small molecule that stabilizes HIF1α by blocking its interaction with VHL and show that it promotes wound healing in mouse models of diabetes.
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Nature Portfolio
2021
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| Acceso en línea: | https://doaj.org/article/ab01c58730bb45109483db19c65692d4 |
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oai:doaj.org-article:ab01c58730bb45109483db19c65692d42021-12-02T17:52:37ZA small molecule HIF-1α stabilizer that accelerates diabetic wound healing10.1038/s41467-021-23448-72041-1723https://doaj.org/article/ab01c58730bb45109483db19c65692d42021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23448-7https://doaj.org/toc/2041-1723Impaired wound healing is a serious complication in diabetic patients, and is associated with reduced HIF1α stability. Here, the authors design a small molecule that stabilizes HIF1α by blocking its interaction with VHL and show that it promotes wound healing in mouse models of diabetes.Guodong LiChung-Nga KoDan LiChao YangWanhe WangGuan-Jun YangCarmelo Di PrimoVincent Kam Wai WongYaozu XiangLigen LinDik-Lung MaChung-Hang LeungNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021) |
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DOAJ |
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EN |
| topic |
Science Q |
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Science Q Guodong Li Chung-Nga Ko Dan Li Chao Yang Wanhe Wang Guan-Jun Yang Carmelo Di Primo Vincent Kam Wai Wong Yaozu Xiang Ligen Lin Dik-Lung Ma Chung-Hang Leung A small molecule HIF-1α stabilizer that accelerates diabetic wound healing |
| description |
Impaired wound healing is a serious complication in diabetic patients, and is associated with reduced HIF1α stability. Here, the authors design a small molecule that stabilizes HIF1α by blocking its interaction with VHL and show that it promotes wound healing in mouse models of diabetes. |
| format |
article |
| author |
Guodong Li Chung-Nga Ko Dan Li Chao Yang Wanhe Wang Guan-Jun Yang Carmelo Di Primo Vincent Kam Wai Wong Yaozu Xiang Ligen Lin Dik-Lung Ma Chung-Hang Leung |
| author_facet |
Guodong Li Chung-Nga Ko Dan Li Chao Yang Wanhe Wang Guan-Jun Yang Carmelo Di Primo Vincent Kam Wai Wong Yaozu Xiang Ligen Lin Dik-Lung Ma Chung-Hang Leung |
| author_sort |
Guodong Li |
| title |
A small molecule HIF-1α stabilizer that accelerates diabetic wound healing |
| title_short |
A small molecule HIF-1α stabilizer that accelerates diabetic wound healing |
| title_full |
A small molecule HIF-1α stabilizer that accelerates diabetic wound healing |
| title_fullStr |
A small molecule HIF-1α stabilizer that accelerates diabetic wound healing |
| title_full_unstemmed |
A small molecule HIF-1α stabilizer that accelerates diabetic wound healing |
| title_sort |
small molecule hif-1α stabilizer that accelerates diabetic wound healing |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/ab01c58730bb45109483db19c65692d4 |
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