A small molecule HIF-1α stabilizer that accelerates diabetic wound healing

A small molecule HIF-1α stabilizer that accelerates diabetic wound healing

Impaired wound healing is a serious complication in diabetic patients, and is associated with reduced HIF1α stability. Here, the authors design a small molecule that stabilizes HIF1α by blocking its interaction with VHL and show that it promotes wound healing in mouse models of diabetes.

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Autores principales: Guodong Li, Chung-Nga Ko, Dan Li, Chao Yang, Wanhe Wang, Guan-Jun Yang, Carmelo Di Primo, Vincent Kam Wai Wong, Yaozu Xiang, Ligen Lin, Dik-Lung Ma, Chung-Hang Leung
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
Q
Acceso en línea:https://doaj.org/article/ab01c58730bb45109483db19c65692d4
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