Gestational age-specific normative values and determinants of serum progesterone through the first trimester of pregnancy

Abstract Progesterone is a steroid hormone that is critical for implantation and maintenance of pregnancy, and low levels are associated with higher miscarriage risk. However, little is known about its trajectory during early pregnancy. We sought to determine the gestational age-specific normative v...

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Autores principales:	Chee Wai Ku, Xiaoxuan Zhang, Valencia Ru-Yan Zhang, John Carson Allen, Nguan Soon Tan, Truls Østbye, Thiam Chye Tan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ab02379dbe6d4b859ab537f50b82a5c3
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spelling	oai:doaj.org-article:ab02379dbe6d4b859ab537f50b82a5c32021-12-02T14:21:51ZGestational age-specific normative values and determinants of serum progesterone through the first trimester of pregnancy10.1038/s41598-021-83805-w2045-2322https://doaj.org/article/ab02379dbe6d4b859ab537f50b82a5c32021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83805-whttps://doaj.org/toc/2045-2322Abstract Progesterone is a steroid hormone that is critical for implantation and maintenance of pregnancy, and low levels are associated with higher miscarriage risk. However, little is known about its trajectory during early pregnancy. We sought to determine the gestational age-specific normative values of serum progesterone on a week-by-week basis, and its associated maternal and fetal factors, during the first trimester of a viable low-risk pregnancy. A cross-sectional study was conducted at KK Women’s and Children’s Hospital from 2013 to 2018. 590 women with a single viable intrauterine low-risk pregnancy, between gestational weeks 5 and 12, were recruited. Serum progesterone showed an increasing trend during the first trimester, with a transient decline between gestational weeks 6–8, corresponding to the luteal–placental shift. Lowest levels were seen at week 7. Maternal age, BMI, parity, gestational age and outcome of pregnancy at 16 weeks’ gestation were found to be associated with progesterone levels. Normative values of serum progesterone for low-risk pregnancies would form the basis for future work on pathological levels of serum progesterone that may increase risk of miscarriage. Larger studies are required to validate these normative values, and personalize them to account for maternal age, BMI, parity and gestational age.Chee Wai KuXiaoxuan ZhangValencia Ru-Yan ZhangJohn Carson AllenNguan Soon TanTruls ØstbyeThiam Chye TanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chee Wai Ku Xiaoxuan Zhang Valencia Ru-Yan Zhang John Carson Allen Nguan Soon Tan Truls Østbye Thiam Chye Tan Gestational age-specific normative values and determinants of serum progesterone through the first trimester of pregnancy
description	Abstract Progesterone is a steroid hormone that is critical for implantation and maintenance of pregnancy, and low levels are associated with higher miscarriage risk. However, little is known about its trajectory during early pregnancy. We sought to determine the gestational age-specific normative values of serum progesterone on a week-by-week basis, and its associated maternal and fetal factors, during the first trimester of a viable low-risk pregnancy. A cross-sectional study was conducted at KK Women’s and Children’s Hospital from 2013 to 2018. 590 women with a single viable intrauterine low-risk pregnancy, between gestational weeks 5 and 12, were recruited. Serum progesterone showed an increasing trend during the first trimester, with a transient decline between gestational weeks 6–8, corresponding to the luteal–placental shift. Lowest levels were seen at week 7. Maternal age, BMI, parity, gestational age and outcome of pregnancy at 16 weeks’ gestation were found to be associated with progesterone levels. Normative values of serum progesterone for low-risk pregnancies would form the basis for future work on pathological levels of serum progesterone that may increase risk of miscarriage. Larger studies are required to validate these normative values, and personalize them to account for maternal age, BMI, parity and gestational age.
format	article
author	Chee Wai Ku Xiaoxuan Zhang Valencia Ru-Yan Zhang John Carson Allen Nguan Soon Tan Truls Østbye Thiam Chye Tan
author_facet	Chee Wai Ku Xiaoxuan Zhang Valencia Ru-Yan Zhang John Carson Allen Nguan Soon Tan Truls Østbye Thiam Chye Tan
author_sort	Chee Wai Ku
title	Gestational age-specific normative values and determinants of serum progesterone through the first trimester of pregnancy
title_short	Gestational age-specific normative values and determinants of serum progesterone through the first trimester of pregnancy
title_full	Gestational age-specific normative values and determinants of serum progesterone through the first trimester of pregnancy
title_fullStr	Gestational age-specific normative values and determinants of serum progesterone through the first trimester of pregnancy
title_full_unstemmed	Gestational age-specific normative values and determinants of serum progesterone through the first trimester of pregnancy
title_sort	gestational age-specific normative values and determinants of serum progesterone through the first trimester of pregnancy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ab02379dbe6d4b859ab537f50b82a5c3
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Gestational age-specific normative values and determinants of serum progesterone through the first trimester of pregnancy

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