Anorexia nervosa of the restrictive type and celiac disease in adolescence

Renata Nacinovich,1 Lucio Tremolizzo,2 Fabiola Corbetta,1 Elisa Conti,2 Francesca Neri,1 Monica Bomba1 1Child and Adolescent Mental Health Department, 2Neurology Unit and Lab of Neurobiology, San Gerardo Hospital, School of Medicine and Surgery and Milan Center for Neuroscience (Neuro-MI), Universi...

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Autores principales:	Nacinovich R, Tremolizzo L, Corbetta F, Conti E, Neri F, Bomba M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Anorexia Nervosa Celiac Disease adolescence Celiac Disease antibody gluten Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/ab068fa443634fcaa47c5e18201c36d1
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spelling	oai:doaj.org-article:ab068fa443634fcaa47c5e18201c36d12021-12-02T08:35:54ZAnorexia nervosa of the restrictive type and celiac disease in adolescence1178-2021https://doaj.org/article/ab068fa443634fcaa47c5e18201c36d12017-05-01T00:00:00Zhttps://www.dovepress.com/anorexia-nervosa-of-the-restrictive-type-and-celiac-disease-in-adolesc-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Renata Nacinovich,1 Lucio Tremolizzo,2 Fabiola Corbetta,1 Elisa Conti,2 Francesca Neri,1 Monica Bomba1 1Child and Adolescent Mental Health Department, 2Neurology Unit and Lab of Neurobiology, San Gerardo Hospital, School of Medicine and Surgery and Milan Center for Neuroscience (Neuro-MI), University of Milano-Bicocca, Monza, Italy Background: Anorexia nervosa (AN) is usually present in adolescence with symptoms partially overlapping celiac disease (CD), but the relationship between these two conditions has received little attention in the literature. The aim of this work was to explore this relationship, considering if CD could be associated with specific baseline AN-related clinical features. Methods: In this retrospective study, 82 adolescent female out- and inpatients with AN of the restrictive type (ANr), according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria, were recruited. CD diagnosis and related serology were recorded, including tissue transglutaminase type-2 antibodies, endomysial antibodies, and antibodies against deamidated forms of gliadin peptides. Eating disorder inventory-3, Children’s Depression Inventory, body mass index, age, and disease duration data recorded at the time of blood withdrawal were also obtained from each patient. Results: Five (6.1%) subjects presented a CD disorder associated with AN: none of the collected psychometric measures was significantly correlated with any CD-related parameter or characterized as a specific subgroup. Conclusion: CD diagnosis or serology does not relate to ANr clinical or demographic characteristics. However, a slight increase in prevalence with respect to the general population might be hypothesized and possibly elucidated by further studies with an appropriate design. Keywords: anorexia nervosa, celiac disease, adolescence, celiac disease antibody, glutenNacinovich RTremolizzo LCorbetta FConti ENeri FBomba MDove Medical PressarticleAnorexia NervosaCeliac DiseaseadolescenceCeliac Disease antibodyglutenNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 1211-1214 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Anorexia Nervosa Celiac Disease adolescence Celiac Disease antibody gluten Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Anorexia Nervosa Celiac Disease adolescence Celiac Disease antibody gluten Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Nacinovich R Tremolizzo L Corbetta F Conti E Neri F Bomba M Anorexia nervosa of the restrictive type and celiac disease in adolescence
description	Renata Nacinovich,1 Lucio Tremolizzo,2 Fabiola Corbetta,1 Elisa Conti,2 Francesca Neri,1 Monica Bomba1 1Child and Adolescent Mental Health Department, 2Neurology Unit and Lab of Neurobiology, San Gerardo Hospital, School of Medicine and Surgery and Milan Center for Neuroscience (Neuro-MI), University of Milano-Bicocca, Monza, Italy Background: Anorexia nervosa (AN) is usually present in adolescence with symptoms partially overlapping celiac disease (CD), but the relationship between these two conditions has received little attention in the literature. The aim of this work was to explore this relationship, considering if CD could be associated with specific baseline AN-related clinical features. Methods: In this retrospective study, 82 adolescent female out- and inpatients with AN of the restrictive type (ANr), according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria, were recruited. CD diagnosis and related serology were recorded, including tissue transglutaminase type-2 antibodies, endomysial antibodies, and antibodies against deamidated forms of gliadin peptides. Eating disorder inventory-3, Children’s Depression Inventory, body mass index, age, and disease duration data recorded at the time of blood withdrawal were also obtained from each patient. Results: Five (6.1%) subjects presented a CD disorder associated with AN: none of the collected psychometric measures was significantly correlated with any CD-related parameter or characterized as a specific subgroup. Conclusion: CD diagnosis or serology does not relate to ANr clinical or demographic characteristics. However, a slight increase in prevalence with respect to the general population might be hypothesized and possibly elucidated by further studies with an appropriate design. Keywords: anorexia nervosa, celiac disease, adolescence, celiac disease antibody, gluten
format	article
author	Nacinovich R Tremolizzo L Corbetta F Conti E Neri F Bomba M
author_facet	Nacinovich R Tremolizzo L Corbetta F Conti E Neri F Bomba M
author_sort	Nacinovich R
title	Anorexia nervosa of the restrictive type and celiac disease in adolescence
title_short	Anorexia nervosa of the restrictive type and celiac disease in adolescence
title_full	Anorexia nervosa of the restrictive type and celiac disease in adolescence
title_fullStr	Anorexia nervosa of the restrictive type and celiac disease in adolescence
title_full_unstemmed	Anorexia nervosa of the restrictive type and celiac disease in adolescence
title_sort	anorexia nervosa of the restrictive type and celiac disease in adolescence
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/ab068fa443634fcaa47c5e18201c36d1
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Anorexia nervosa of the restrictive type and celiac disease in adolescence

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