Two-input protein logic gate for computation in living cells

Traditional synthetic biology tools operate by complex re-programming of DNA, requiring significant amount of ‘nucleotide-based code’ to implement instructions that are transcribed at the protein level. Here the authors demonstrate the direct regulation of cellular phenotype at the single-protein le...

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Autores principales:	Yashavantha L. Vishweshwaraiah, Jiaxing Chen, Venkat R. Chirasani, Erdem D. Tabdanov, Nikolay V. Dokholyan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ab071c86d66445339a7e6c2b7d6132f6
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spelling	oai:doaj.org-article:ab071c86d66445339a7e6c2b7d6132f62021-11-21T12:34:21ZTwo-input protein logic gate for computation in living cells10.1038/s41467-021-26937-x2041-1723https://doaj.org/article/ab071c86d66445339a7e6c2b7d6132f62021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26937-xhttps://doaj.org/toc/2041-1723Traditional synthetic biology tools operate by complex re-programming of DNA, requiring significant amount of ‘nucleotide-based code’ to implement instructions that are transcribed at the protein level. Here the authors demonstrate the direct regulation of cellular phenotype at the single-protein level by creating a two-input logic gate for biological computation using ‘allosteric wiring’.Yashavantha L. VishweshwaraiahJiaxing ChenVenkat R. ChirasaniErdem D. TabdanovNikolay V. DokholyanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yashavantha L. Vishweshwaraiah Jiaxing Chen Venkat R. Chirasani Erdem D. Tabdanov Nikolay V. Dokholyan Two-input protein logic gate for computation in living cells
description	Traditional synthetic biology tools operate by complex re-programming of DNA, requiring significant amount of ‘nucleotide-based code’ to implement instructions that are transcribed at the protein level. Here the authors demonstrate the direct regulation of cellular phenotype at the single-protein level by creating a two-input logic gate for biological computation using ‘allosteric wiring’.
format	article
author	Yashavantha L. Vishweshwaraiah Jiaxing Chen Venkat R. Chirasani Erdem D. Tabdanov Nikolay V. Dokholyan
author_facet	Yashavantha L. Vishweshwaraiah Jiaxing Chen Venkat R. Chirasani Erdem D. Tabdanov Nikolay V. Dokholyan
author_sort	Yashavantha L. Vishweshwaraiah
title	Two-input protein logic gate for computation in living cells
title_short	Two-input protein logic gate for computation in living cells
title_full	Two-input protein logic gate for computation in living cells
title_fullStr	Two-input protein logic gate for computation in living cells
title_full_unstemmed	Two-input protein logic gate for computation in living cells
title_sort	two-input protein logic gate for computation in living cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ab071c86d66445339a7e6c2b7d6132f6
work_keys_str_mv	AT yashavanthalvishweshwaraiah twoinputproteinlogicgateforcomputationinlivingcells AT jiaxingchen twoinputproteinlogicgateforcomputationinlivingcells AT venkatrchirasani twoinputproteinlogicgateforcomputationinlivingcells AT erdemdtabdanov twoinputproteinlogicgateforcomputationinlivingcells AT nikolayvdokholyan twoinputproteinlogicgateforcomputationinlivingcells
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Two-input protein logic gate for computation in living cells

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