Skewness of X-chromosome inactivation increases with age and varies across birth cohorts in elderly Danish women

Abstract Mosaicism in blood varies with age, and cross-sectional studies indicate that for women, skewness of X-chromosomal mosaicism increases with age. This pattern could, however, also be due to less X-inactivation in more recent birth cohorts. Skewed X-chromosome inactivation was here measured l...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jonas Mengel-From, Rune Lindahl-Jacobsen, Marianne Nygaard, Mette Soerensen, Karen Helene Ørstavik, Jens Michael Hertz, Karen Andersen-Ranberg, Qihua Tan, Kaare Christensen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ab07ac69036a4bceb82d8564985ca5bb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ab07ac69036a4bceb82d8564985ca5bb
record_format	dspace
spelling	oai:doaj.org-article:ab07ac69036a4bceb82d8564985ca5bb2021-12-02T14:28:22ZSkewness of X-chromosome inactivation increases with age and varies across birth cohorts in elderly Danish women10.1038/s41598-021-83702-22045-2322https://doaj.org/article/ab07ac69036a4bceb82d8564985ca5bb2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83702-2https://doaj.org/toc/2045-2322Abstract Mosaicism in blood varies with age, and cross-sectional studies indicate that for women, skewness of X-chromosomal mosaicism increases with age. This pattern could, however, also be due to less X-inactivation in more recent birth cohorts. Skewed X-chromosome inactivation was here measured longitudinally by the HUMARA assay in 67 septuagenarian and octogenarian women assessed at 2 time points, 10 years apart, and in 10 centenarian women assessed at 2 time points, 2–7 years apart. Skewed X-chromosome inactivation was also compared in 293 age-matched septuagenarian twins born in 1917–1923 and 1931–1937, and 212 centenarians born in 1895, 1905 and 1915. The longitudinal study of septuagenarians and octogenarians revealed that 16% (95% CI 7–29%) of the women developed skewed X-inactivation over a 10-year period. In the cross-sectional across-birth cohort study, the earlier-born septuagenarian (1917–1923) and centenarian women (1895) had a higher degree of skewness than the respective recent age-matched birth cohorts, which indicates that the women in the more recent cohorts, after the age of 70, had not only changed degree of skewness with age, they had also undergone less age-related hematopoietic sub-clone expansion. This may be a result of improved living conditions and better medical treatment in the more recent birth cohorts.Jonas Mengel-FromRune Lindahl-JacobsenMarianne NygaardMette SoerensenKaren Helene ØrstavikJens Michael HertzKaren Andersen-RanbergQihua TanKaare ChristensenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jonas Mengel-From Rune Lindahl-Jacobsen Marianne Nygaard Mette Soerensen Karen Helene Ørstavik Jens Michael Hertz Karen Andersen-Ranberg Qihua Tan Kaare Christensen Skewness of X-chromosome inactivation increases with age and varies across birth cohorts in elderly Danish women
description	Abstract Mosaicism in blood varies with age, and cross-sectional studies indicate that for women, skewness of X-chromosomal mosaicism increases with age. This pattern could, however, also be due to less X-inactivation in more recent birth cohorts. Skewed X-chromosome inactivation was here measured longitudinally by the HUMARA assay in 67 septuagenarian and octogenarian women assessed at 2 time points, 10 years apart, and in 10 centenarian women assessed at 2 time points, 2–7 years apart. Skewed X-chromosome inactivation was also compared in 293 age-matched septuagenarian twins born in 1917–1923 and 1931–1937, and 212 centenarians born in 1895, 1905 and 1915. The longitudinal study of septuagenarians and octogenarians revealed that 16% (95% CI 7–29%) of the women developed skewed X-inactivation over a 10-year period. In the cross-sectional across-birth cohort study, the earlier-born septuagenarian (1917–1923) and centenarian women (1895) had a higher degree of skewness than the respective recent age-matched birth cohorts, which indicates that the women in the more recent cohorts, after the age of 70, had not only changed degree of skewness with age, they had also undergone less age-related hematopoietic sub-clone expansion. This may be a result of improved living conditions and better medical treatment in the more recent birth cohorts.
format	article
author	Jonas Mengel-From Rune Lindahl-Jacobsen Marianne Nygaard Mette Soerensen Karen Helene Ørstavik Jens Michael Hertz Karen Andersen-Ranberg Qihua Tan Kaare Christensen
author_facet	Jonas Mengel-From Rune Lindahl-Jacobsen Marianne Nygaard Mette Soerensen Karen Helene Ørstavik Jens Michael Hertz Karen Andersen-Ranberg Qihua Tan Kaare Christensen
author_sort	Jonas Mengel-From
title	Skewness of X-chromosome inactivation increases with age and varies across birth cohorts in elderly Danish women
title_short	Skewness of X-chromosome inactivation increases with age and varies across birth cohorts in elderly Danish women
title_full	Skewness of X-chromosome inactivation increases with age and varies across birth cohorts in elderly Danish women
title_fullStr	Skewness of X-chromosome inactivation increases with age and varies across birth cohorts in elderly Danish women
title_full_unstemmed	Skewness of X-chromosome inactivation increases with age and varies across birth cohorts in elderly Danish women
title_sort	skewness of x-chromosome inactivation increases with age and varies across birth cohorts in elderly danish women
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ab07ac69036a4bceb82d8564985ca5bb
work_keys_str_mv	AT jonasmengelfrom skewnessofxchromosomeinactivationincreaseswithageandvariesacrossbirthcohortsinelderlydanishwomen AT runelindahljacobsen skewnessofxchromosomeinactivationincreaseswithageandvariesacrossbirthcohortsinelderlydanishwomen AT mariannenygaard skewnessofxchromosomeinactivationincreaseswithageandvariesacrossbirthcohortsinelderlydanishwomen AT mettesoerensen skewnessofxchromosomeinactivationincreaseswithageandvariesacrossbirthcohortsinelderlydanishwomen AT karenheleneørstavik skewnessofxchromosomeinactivationincreaseswithageandvariesacrossbirthcohortsinelderlydanishwomen AT jensmichaelhertz skewnessofxchromosomeinactivationincreaseswithageandvariesacrossbirthcohortsinelderlydanishwomen AT karenandersenranberg skewnessofxchromosomeinactivationincreaseswithageandvariesacrossbirthcohortsinelderlydanishwomen AT qihuatan skewnessofxchromosomeinactivationincreaseswithageandvariesacrossbirthcohortsinelderlydanishwomen AT kaarechristensen skewnessofxchromosomeinactivationincreaseswithageandvariesacrossbirthcohortsinelderlydanishwomen
_version_	1718391272726593536

Skewness of X-chromosome inactivation increases with age and varies across birth cohorts in elderly Danish women

Ejemplares similares