Analysis of the role of Ly-1 antibody reactive in different cancer types

LYAR (Ly-1 antibody reactive) is a transcription factor with a specific DNA-binding domain, which plays a key role in the regulation of embryonic stem cell self-renewal and differentiation. However, the role of LYAR in human cancers remains unclear. This study aimed to analyze the prognostic value o...

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Autores principales:	Linlin Chen, Congwen Jin, Hao Liu, Rongmei Feng, Zhengdong Li, Jiasheng Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	lyar hepatocellular carcinoma tcga prognosis cancer Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/ab08fdb204404f228ebfda2d03f29571
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spelling	oai:doaj.org-article:ab08fdb204404f228ebfda2d03f295712021-11-04T15:51:54ZAnalysis of the role of Ly-1 antibody reactive in different cancer types2165-59792165-598710.1080/21655979.2021.1995100https://doaj.org/article/ab08fdb204404f228ebfda2d03f295712021-10-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.1995100https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987LYAR (Ly-1 antibody reactive) is a transcription factor with a specific DNA-binding domain, which plays a key role in the regulation of embryonic stem cell self-renewal and differentiation. However, the role of LYAR in human cancers remains unclear. This study aimed to analyze the prognostic value of LYAR in cancer. In this study, we evaluated the prognostic value of LYAR in various tumors. We research found that, compared with normal tissues, LYAR levels werehigher in a variety of tumors. LYAR expression level was associated with poor overall survival, progression-free interval, and disease-specific survival. LYAR expression was also related to tumor grade, stage, age, and tumor status. Cell counting kit-8, Transwell, and wound healing assay showed that knocking out LYAR significantly inhibited the proliferation, migration, and invasion of hepatocellular carcinoma cells. In addition, this study found that LYARexpression was significantly positively correlated with MKI67IP, BZW2, and CCT2. Gene set enrichment analysis results showed that samples with high LYAR expression levels were rich in spliceosomes, RNA degradation, pyrimidine metabolism, cell cycle, nucleotide excision repair, and base excision repair.Linlin ChenCongwen JinHao LiuRongmei FengZhengdong LiJiasheng ZhangTaylor & Francis Grouparticlelyarhepatocellular carcinomatcgaprognosiscancerBiotechnologyTP248.13-248.65ENBioengineered, Vol 0, Iss 0 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lyar hepatocellular carcinoma tcga prognosis cancer Biotechnology TP248.13-248.65
spellingShingle	lyar hepatocellular carcinoma tcga prognosis cancer Biotechnology TP248.13-248.65 Linlin Chen Congwen Jin Hao Liu Rongmei Feng Zhengdong Li Jiasheng Zhang Analysis of the role of Ly-1 antibody reactive in different cancer types
description	LYAR (Ly-1 antibody reactive) is a transcription factor with a specific DNA-binding domain, which plays a key role in the regulation of embryonic stem cell self-renewal and differentiation. However, the role of LYAR in human cancers remains unclear. This study aimed to analyze the prognostic value of LYAR in cancer. In this study, we evaluated the prognostic value of LYAR in various tumors. We research found that, compared with normal tissues, LYAR levels werehigher in a variety of tumors. LYAR expression level was associated with poor overall survival, progression-free interval, and disease-specific survival. LYAR expression was also related to tumor grade, stage, age, and tumor status. Cell counting kit-8, Transwell, and wound healing assay showed that knocking out LYAR significantly inhibited the proliferation, migration, and invasion of hepatocellular carcinoma cells. In addition, this study found that LYARexpression was significantly positively correlated with MKI67IP, BZW2, and CCT2. Gene set enrichment analysis results showed that samples with high LYAR expression levels were rich in spliceosomes, RNA degradation, pyrimidine metabolism, cell cycle, nucleotide excision repair, and base excision repair.
format	article
author	Linlin Chen Congwen Jin Hao Liu Rongmei Feng Zhengdong Li Jiasheng Zhang
author_facet	Linlin Chen Congwen Jin Hao Liu Rongmei Feng Zhengdong Li Jiasheng Zhang
author_sort	Linlin Chen
title	Analysis of the role of Ly-1 antibody reactive in different cancer types
title_short	Analysis of the role of Ly-1 antibody reactive in different cancer types
title_full	Analysis of the role of Ly-1 antibody reactive in different cancer types
title_fullStr	Analysis of the role of Ly-1 antibody reactive in different cancer types
title_full_unstemmed	Analysis of the role of Ly-1 antibody reactive in different cancer types
title_sort	analysis of the role of ly-1 antibody reactive in different cancer types
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/ab08fdb204404f228ebfda2d03f29571
work_keys_str_mv	AT linlinchen analysisoftheroleofly1antibodyreactiveindifferentcancertypes AT congwenjin analysisoftheroleofly1antibodyreactiveindifferentcancertypes AT haoliu analysisoftheroleofly1antibodyreactiveindifferentcancertypes AT rongmeifeng analysisoftheroleofly1antibodyreactiveindifferentcancertypes AT zhengdongli analysisoftheroleofly1antibodyreactiveindifferentcancertypes AT jiashengzhang analysisoftheroleofly1antibodyreactiveindifferentcancertypes
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Analysis of the role of Ly-1 antibody reactive in different cancer types

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