CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module
The mechanism by which adenosine monophosphate modulates dynein ATPase-mediated ciliary and flagellar beating remains obscure. Here the authors identify an axonemal module including cilia and flagella associated protein 45 that supports adenine nucleotide homeostasis and underlies a human ciliopathy
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Nature Portfolio
2020
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oai:doaj.org-article:ab0a6ca10924497e88909fc70b9718402021-12-02T15:33:51ZCFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module10.1038/s41467-020-19113-02041-1723https://doaj.org/article/ab0a6ca10924497e88909fc70b9718402020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19113-0https://doaj.org/toc/2041-1723The mechanism by which adenosine monophosphate modulates dynein ATPase-mediated ciliary and flagellar beating remains obscure. Here the authors identify an axonemal module including cilia and flagella associated protein 45 that supports adenine nucleotide homeostasis and underlies a human ciliopathyGerard W. DoughertyKatsutoshi MizunoTabea Nöthe-MenchenYayoi IkawaKarsten BoldtAsaf Ta-ShmaIsabella ApreaKatsura MinegishiYuan-Ping PangPetra PennekampNiki T. LogesJohanna RaidtRim HjeijJulia WallmeierHuda MussaffiZeev PerlesOrly ElpelegFranziska RabertHidetaka ShiratoriStef J. LetteboerNicola HornSamuel YoungTimo StrünkerFriederike StummeClaudius WernerHeike OlbrichKatsuyoshi TakaokaTakahiro IdeWang Kyaw TwanLuisa BiebachJörg Große-OnnebrinkJudith A. KlinkenbuschKavita PraveenDiana C. BrachtInga M. HöbenKatrin JungerJana GützlaffSandra CindrićMicha AviramThomas KaiserYasin MemariPetras P. DzejaBernd DworniczakMarius UeffingRonald RoepmanKerstin BartschererNicholas KatsanisErica E. DavisIsrael AmiravHiroshi HamadaHeymut OmranNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-20 (2020) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
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Science Q Gerard W. Dougherty Katsutoshi Mizuno Tabea Nöthe-Menchen Yayoi Ikawa Karsten Boldt Asaf Ta-Shma Isabella Aprea Katsura Minegishi Yuan-Ping Pang Petra Pennekamp Niki T. Loges Johanna Raidt Rim Hjeij Julia Wallmeier Huda Mussaffi Zeev Perles Orly Elpeleg Franziska Rabert Hidetaka Shiratori Stef J. Letteboer Nicola Horn Samuel Young Timo Strünker Friederike Stumme Claudius Werner Heike Olbrich Katsuyoshi Takaoka Takahiro Ide Wang Kyaw Twan Luisa Biebach Jörg Große-Onnebrink Judith A. Klinkenbusch Kavita Praveen Diana C. Bracht Inga M. Höben Katrin Junger Jana Gützlaff Sandra Cindrić Micha Aviram Thomas Kaiser Yasin Memari Petras P. Dzeja Bernd Dworniczak Marius Ueffing Ronald Roepman Kerstin Bartscherer Nicholas Katsanis Erica E. Davis Israel Amirav Hiroshi Hamada Heymut Omran CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module |
| description |
The mechanism by which adenosine monophosphate modulates dynein ATPase-mediated ciliary and flagellar beating remains obscure. Here the authors identify an axonemal module including cilia and flagella associated protein 45 that supports adenine nucleotide homeostasis and underlies a human ciliopathy |
| format |
article |
| author |
Gerard W. Dougherty Katsutoshi Mizuno Tabea Nöthe-Menchen Yayoi Ikawa Karsten Boldt Asaf Ta-Shma Isabella Aprea Katsura Minegishi Yuan-Ping Pang Petra Pennekamp Niki T. Loges Johanna Raidt Rim Hjeij Julia Wallmeier Huda Mussaffi Zeev Perles Orly Elpeleg Franziska Rabert Hidetaka Shiratori Stef J. Letteboer Nicola Horn Samuel Young Timo Strünker Friederike Stumme Claudius Werner Heike Olbrich Katsuyoshi Takaoka Takahiro Ide Wang Kyaw Twan Luisa Biebach Jörg Große-Onnebrink Judith A. Klinkenbusch Kavita Praveen Diana C. Bracht Inga M. Höben Katrin Junger Jana Gützlaff Sandra Cindrić Micha Aviram Thomas Kaiser Yasin Memari Petras P. Dzeja Bernd Dworniczak Marius Ueffing Ronald Roepman Kerstin Bartscherer Nicholas Katsanis Erica E. Davis Israel Amirav Hiroshi Hamada Heymut Omran |
| author_facet |
Gerard W. Dougherty Katsutoshi Mizuno Tabea Nöthe-Menchen Yayoi Ikawa Karsten Boldt Asaf Ta-Shma Isabella Aprea Katsura Minegishi Yuan-Ping Pang Petra Pennekamp Niki T. Loges Johanna Raidt Rim Hjeij Julia Wallmeier Huda Mussaffi Zeev Perles Orly Elpeleg Franziska Rabert Hidetaka Shiratori Stef J. Letteboer Nicola Horn Samuel Young Timo Strünker Friederike Stumme Claudius Werner Heike Olbrich Katsuyoshi Takaoka Takahiro Ide Wang Kyaw Twan Luisa Biebach Jörg Große-Onnebrink Judith A. Klinkenbusch Kavita Praveen Diana C. Bracht Inga M. Höben Katrin Junger Jana Gützlaff Sandra Cindrić Micha Aviram Thomas Kaiser Yasin Memari Petras P. Dzeja Bernd Dworniczak Marius Ueffing Ronald Roepman Kerstin Bartscherer Nicholas Katsanis Erica E. Davis Israel Amirav Hiroshi Hamada Heymut Omran |
| author_sort |
Gerard W. Dougherty |
| title |
CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module |
| title_short |
CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module |
| title_full |
CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module |
| title_fullStr |
CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module |
| title_full_unstemmed |
CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module |
| title_sort |
cfap45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/ab0a6ca10924497e88909fc70b971840 |
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