Astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes

Hypothalamic inflammation is involved in the pathogenesis of diabetes. The underlying mechanisms are unclear. Here, the authors show that astrocytic PDK2 ablation or inhibition attenuates hypothalamic inflammation in mouse models of diabetes.

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Autores principales:	Md Habibur Rahman, Anup Bhusal, Jae-Hong Kim, Mithilesh Kumar Jha, Gyun Jee Song, Younghoon Go, Il-Sung Jang, In-Kyu Lee, Kyoungho Suk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ab0aa5b82f814602985d6ffd3a2191a4
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spelling	oai:doaj.org-article:ab0aa5b82f814602985d6ffd3a2191a42021-12-02T14:42:13ZAstrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes10.1038/s41467-020-19576-12041-1723https://doaj.org/article/ab0aa5b82f814602985d6ffd3a2191a42020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19576-1https://doaj.org/toc/2041-1723Hypothalamic inflammation is involved in the pathogenesis of diabetes. The underlying mechanisms are unclear. Here, the authors show that astrocytic PDK2 ablation or inhibition attenuates hypothalamic inflammation in mouse models of diabetes.Md Habibur RahmanAnup BhusalJae-Hong KimMithilesh Kumar JhaGyun Jee SongYounghoon GoIl-Sung JangIn-Kyu LeeKyoungho SukNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Md Habibur Rahman Anup Bhusal Jae-Hong Kim Mithilesh Kumar Jha Gyun Jee Song Younghoon Go Il-Sung Jang In-Kyu Lee Kyoungho Suk Astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes
description	Hypothalamic inflammation is involved in the pathogenesis of diabetes. The underlying mechanisms are unclear. Here, the authors show that astrocytic PDK2 ablation or inhibition attenuates hypothalamic inflammation in mouse models of diabetes.
format	article
author	Md Habibur Rahman Anup Bhusal Jae-Hong Kim Mithilesh Kumar Jha Gyun Jee Song Younghoon Go Il-Sung Jang In-Kyu Lee Kyoungho Suk
author_facet	Md Habibur Rahman Anup Bhusal Jae-Hong Kim Mithilesh Kumar Jha Gyun Jee Song Younghoon Go Il-Sung Jang In-Kyu Lee Kyoungho Suk
author_sort	Md Habibur Rahman
title	Astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes
title_short	Astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes
title_full	Astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes
title_fullStr	Astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes
title_full_unstemmed	Astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes
title_sort	astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ab0aa5b82f814602985d6ffd3a2191a4
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Astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes

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