Obesity Prolongs the Inflammatory Response in Mice After Severe Trauma and Attenuates the Splenic Response to the Inflammatory Reflex

Thoracic traumas with extra-thoracic injuries result in an immediate, complex host response. The immune response requires tight regulation and can be influenced by additional risk factors such as obesity, which is considered a state of chronic inflammation. Utilizing high-dimensional mass and regula...

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Autores principales:	Fabian Gärtner, Adrian Gihring, Aileen Roth, Joachim Bischof, Pengfei Xu, Leonard Elad, Martin Wabitsch, Timo Burster, Uwe Knippschild
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	obesity immune response severe trauma inflammatory reflex monocyte compartment mass cytometry (CyTOF) Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/ab0c9b3255ae41f583bd5de956d4e05b
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spelling	oai:doaj.org-article:ab0c9b3255ae41f583bd5de956d4e05b2021-11-15T06:54:49ZObesity Prolongs the Inflammatory Response in Mice After Severe Trauma and Attenuates the Splenic Response to the Inflammatory Reflex1664-322410.3389/fimmu.2021.745132https://doaj.org/article/ab0c9b3255ae41f583bd5de956d4e05b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.745132/fullhttps://doaj.org/toc/1664-3224Thoracic traumas with extra-thoracic injuries result in an immediate, complex host response. The immune response requires tight regulation and can be influenced by additional risk factors such as obesity, which is considered a state of chronic inflammation. Utilizing high-dimensional mass and regular flow cytometry, we define key signatures of obesity-related alterations of the immune system during the response to the trauma. In this context, we report a modification in important components of the splenic response to the inflammatory reflex in obese mice. Furthermore, during the response to trauma, obese mice exhibit a prolonged increase of neutrophils and an early accumulation of inflammation associated CCR2+CD62L+Ly6Chi monocytes in the blood, contributing to a persistent inflammatory phase. Moreover, these mice exhibit differences in migration patterns of monocytes to the traumatized lung, resulting in decreased numbers of regenerative macrophages and an impaired M1/M2 switch in traumatized lungs. The findings presented in this study reveal an attenuation of the inflammatory reflex in obese mice, as well as a disturbance of the monocytic compartment contributing to a prolonged inflammation phase resulting in fewer phenotypically regenerative macrophages in the lung of obese mice.Fabian GärtnerAdrian GihringAileen RothJoachim BischofPengfei XuLeonard EladMartin WabitschTimo BursterUwe KnippschildFrontiers Media S.A.articleobesityimmune responsesevere traumainflammatory reflexmonocyte compartmentmass cytometry (CyTOF)Immunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	obesity immune response severe trauma inflammatory reflex monocyte compartment mass cytometry (CyTOF) Immunologic diseases. Allergy RC581-607
spellingShingle	obesity immune response severe trauma inflammatory reflex monocyte compartment mass cytometry (CyTOF) Immunologic diseases. Allergy RC581-607 Fabian Gärtner Adrian Gihring Aileen Roth Joachim Bischof Pengfei Xu Leonard Elad Martin Wabitsch Timo Burster Uwe Knippschild Obesity Prolongs the Inflammatory Response in Mice After Severe Trauma and Attenuates the Splenic Response to the Inflammatory Reflex
description	Thoracic traumas with extra-thoracic injuries result in an immediate, complex host response. The immune response requires tight regulation and can be influenced by additional risk factors such as obesity, which is considered a state of chronic inflammation. Utilizing high-dimensional mass and regular flow cytometry, we define key signatures of obesity-related alterations of the immune system during the response to the trauma. In this context, we report a modification in important components of the splenic response to the inflammatory reflex in obese mice. Furthermore, during the response to trauma, obese mice exhibit a prolonged increase of neutrophils and an early accumulation of inflammation associated CCR2+CD62L+Ly6Chi monocytes in the blood, contributing to a persistent inflammatory phase. Moreover, these mice exhibit differences in migration patterns of monocytes to the traumatized lung, resulting in decreased numbers of regenerative macrophages and an impaired M1/M2 switch in traumatized lungs. The findings presented in this study reveal an attenuation of the inflammatory reflex in obese mice, as well as a disturbance of the monocytic compartment contributing to a prolonged inflammation phase resulting in fewer phenotypically regenerative macrophages in the lung of obese mice.
format	article
author	Fabian Gärtner Adrian Gihring Aileen Roth Joachim Bischof Pengfei Xu Leonard Elad Martin Wabitsch Timo Burster Uwe Knippschild
author_facet	Fabian Gärtner Adrian Gihring Aileen Roth Joachim Bischof Pengfei Xu Leonard Elad Martin Wabitsch Timo Burster Uwe Knippschild
author_sort	Fabian Gärtner
title	Obesity Prolongs the Inflammatory Response in Mice After Severe Trauma and Attenuates the Splenic Response to the Inflammatory Reflex
title_short	Obesity Prolongs the Inflammatory Response in Mice After Severe Trauma and Attenuates the Splenic Response to the Inflammatory Reflex
title_full	Obesity Prolongs the Inflammatory Response in Mice After Severe Trauma and Attenuates the Splenic Response to the Inflammatory Reflex
title_fullStr	Obesity Prolongs the Inflammatory Response in Mice After Severe Trauma and Attenuates the Splenic Response to the Inflammatory Reflex
title_full_unstemmed	Obesity Prolongs the Inflammatory Response in Mice After Severe Trauma and Attenuates the Splenic Response to the Inflammatory Reflex
title_sort	obesity prolongs the inflammatory response in mice after severe trauma and attenuates the splenic response to the inflammatory reflex
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ab0c9b3255ae41f583bd5de956d4e05b
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Obesity Prolongs the Inflammatory Response in Mice After Severe Trauma and Attenuates the Splenic Response to the Inflammatory Reflex

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