Oxygen supersaturated fluid using fine micro/nanobubbles

Noriaki Matsuki,1 Takuji Ishikawa,2 Shingo Ichiba,3 Naoki Shiba,3 Yoshihito Ujike,3 Takami Yamaguchi4 1Department of Biomedical Engineering, Graduate School of Engineering, Okayama University of Science, Okayama, 2Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku Uni...

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Autores principales:	Matsuki N, Ishikawa T, Ichiba S, Shiba N, Ujike Y, Yamaguchi T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ab0e88c375184ff99a3a5f12dbf3509c
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spelling	oai:doaj.org-article:ab0e88c375184ff99a3a5f12dbf3509c2021-12-02T01:46:44ZOxygen supersaturated fluid using fine micro/nanobubbles1178-2013https://doaj.org/article/ab0e88c375184ff99a3a5f12dbf3509c2014-09-01T00:00:00Zhttp://www.dovepress.com/oxygen-supersaturated-fluid-using-fine-micronanobubbles-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Noriaki Matsuki,1 Takuji Ishikawa,2 Shingo Ichiba,3 Naoki Shiba,3 Yoshihito Ujike,3 Takami Yamaguchi4 1Department of Biomedical Engineering, Graduate School of Engineering, Okayama University of Science, Okayama, 2Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, Sendai, 3Department of Emergency and Critical Care Medicine, Okayama University Hospital, Okayama, 4Graduate School of Biomedical Engineering, Tohoku University, Sendai, JapanAbstract: Microbubbles show peculiar properties, such as shrinking collapse, long lifetime, high gas solubility, negative electric charge, and free radical production. Fluids supersaturated with various gases can be easily generated using microbubbles. Oxygen microbubble fluid can be very useful for oxygen delivery to hypoxic tissues. However, there have been no reports of comparative investigations into adding fluids containing oxygen fine micro/nanobubbles (OFMNBs) to common infusion solutions in daily medical care. In this study, it was demonstrated that OFMNBs can generate oxygen-supersaturated fluids, and they may be sufficiently small to infuse safely into blood vessels. It was found that normal saline solution is preferable for generating an oxygen-rich infusion fluid, which is best administered as a 30-minute intravenous infusion. It was also concluded that dextran solution is suitable for drug delivery substances packing oxygen gas over a 1-hour intravenous infusion. In addition, normal saline solution containing OFMNBs was effective for improving blood oxygenation. Thus, the use of OFMNB-containing fluids is a potentially effective novel method for improving blood oxygenation in cases involving hypoxia, ischemic diseases, infection control, and anticancer chemoradiation therapies.Keywords: microbubble, fine micro/nanobubble, nanobubble, oxygenation, fluid oxygenationMatsuki NIshikawa TIchiba SShiba NUjike YYamaguchi TDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 4495-4505 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Matsuki N Ishikawa T Ichiba S Shiba N Ujike Y Yamaguchi T Oxygen supersaturated fluid using fine micro/nanobubbles
description	Noriaki Matsuki,1 Takuji Ishikawa,2 Shingo Ichiba,3 Naoki Shiba,3 Yoshihito Ujike,3 Takami Yamaguchi4 1Department of Biomedical Engineering, Graduate School of Engineering, Okayama University of Science, Okayama, 2Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, Sendai, 3Department of Emergency and Critical Care Medicine, Okayama University Hospital, Okayama, 4Graduate School of Biomedical Engineering, Tohoku University, Sendai, JapanAbstract: Microbubbles show peculiar properties, such as shrinking collapse, long lifetime, high gas solubility, negative electric charge, and free radical production. Fluids supersaturated with various gases can be easily generated using microbubbles. Oxygen microbubble fluid can be very useful for oxygen delivery to hypoxic tissues. However, there have been no reports of comparative investigations into adding fluids containing oxygen fine micro/nanobubbles (OFMNBs) to common infusion solutions in daily medical care. In this study, it was demonstrated that OFMNBs can generate oxygen-supersaturated fluids, and they may be sufficiently small to infuse safely into blood vessels. It was found that normal saline solution is preferable for generating an oxygen-rich infusion fluid, which is best administered as a 30-minute intravenous infusion. It was also concluded that dextran solution is suitable for drug delivery substances packing oxygen gas over a 1-hour intravenous infusion. In addition, normal saline solution containing OFMNBs was effective for improving blood oxygenation. Thus, the use of OFMNB-containing fluids is a potentially effective novel method for improving blood oxygenation in cases involving hypoxia, ischemic diseases, infection control, and anticancer chemoradiation therapies.Keywords: microbubble, fine micro/nanobubble, nanobubble, oxygenation, fluid oxygenation
format	article
author	Matsuki N Ishikawa T Ichiba S Shiba N Ujike Y Yamaguchi T
author_facet	Matsuki N Ishikawa T Ichiba S Shiba N Ujike Y Yamaguchi T
author_sort	Matsuki N
title	Oxygen supersaturated fluid using fine micro/nanobubbles
title_short	Oxygen supersaturated fluid using fine micro/nanobubbles
title_full	Oxygen supersaturated fluid using fine micro/nanobubbles
title_fullStr	Oxygen supersaturated fluid using fine micro/nanobubbles
title_full_unstemmed	Oxygen supersaturated fluid using fine micro/nanobubbles
title_sort	oxygen supersaturated fluid using fine micro/nanobubbles
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/ab0e88c375184ff99a3a5f12dbf3509c
work_keys_str_mv	AT matsukin oxygensupersaturatedfluidusingfinemicronanobubbles AT ishikawat oxygensupersaturatedfluidusingfinemicronanobubbles AT ichibas oxygensupersaturatedfluidusingfinemicronanobubbles AT shiban oxygensupersaturatedfluidusingfinemicronanobubbles AT ujikey oxygensupersaturatedfluidusingfinemicronanobubbles AT yamaguchit oxygensupersaturatedfluidusingfinemicronanobubbles
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Oxygen supersaturated fluid using fine micro/nanobubbles

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