Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5

Cancer cells are reliant on nutrients such as glutamine, which enter the cell via the alanine/serine/cysteine transporter 2 (ASCT2). Here, authors use crystallography to show which amino-acid residues in the substrate-binding site are responsible for conferring glutamine selectivity to ASCT2.

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Autores principales:	Amanda J Scopelliti, Josep Font, Robert J Vandenberg, Olga Boudker, Renae M Ryan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ab0f2812dab54201a550d895712c496d
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spelling	oai:doaj.org-article:ab0f2812dab54201a550d895712c496d2021-12-02T17:32:49ZStructural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A510.1038/s41467-017-02444-w2041-1723https://doaj.org/article/ab0f2812dab54201a550d895712c496d2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02444-whttps://doaj.org/toc/2041-1723Cancer cells are reliant on nutrients such as glutamine, which enter the cell via the alanine/serine/cysteine transporter 2 (ASCT2). Here, authors use crystallography to show which amino-acid residues in the substrate-binding site are responsible for conferring glutamine selectivity to ASCT2.Amanda J ScopellitiJosep FontRobert J VandenbergOlga BoudkerRenae M RyanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amanda J Scopelliti Josep Font Robert J Vandenberg Olga Boudker Renae M Ryan Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5
description	Cancer cells are reliant on nutrients such as glutamine, which enter the cell via the alanine/serine/cysteine transporter 2 (ASCT2). Here, authors use crystallography to show which amino-acid residues in the substrate-binding site are responsible for conferring glutamine selectivity to ASCT2.
format	article
author	Amanda J Scopelliti Josep Font Robert J Vandenberg Olga Boudker Renae M Ryan
author_facet	Amanda J Scopelliti Josep Font Robert J Vandenberg Olga Boudker Renae M Ryan
author_sort	Amanda J Scopelliti
title	Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5
title_short	Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5
title_full	Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5
title_fullStr	Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5
title_full_unstemmed	Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5
title_sort	structural characterisation reveals insights into substrate recognition by the glutamine transporter asct2/slc1a5
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ab0f2812dab54201a550d895712c496d
work_keys_str_mv	AT amandajscopelliti structuralcharacterisationrevealsinsightsintosubstraterecognitionbytheglutaminetransporterasct2slc1a5 AT josepfont structuralcharacterisationrevealsinsightsintosubstraterecognitionbytheglutaminetransporterasct2slc1a5 AT robertjvandenberg structuralcharacterisationrevealsinsightsintosubstraterecognitionbytheglutaminetransporterasct2slc1a5 AT olgaboudker structuralcharacterisationrevealsinsightsintosubstraterecognitionbytheglutaminetransporterasct2slc1a5 AT renaemryan structuralcharacterisationrevealsinsightsintosubstraterecognitionbytheglutaminetransporterasct2slc1a5
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Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5

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