The relationship of polluted air and drinking water sources with the prevalence of systemic lupus erythematosus: a provincial population-based study

The relationship of polluted air and drinking water sources with the prevalence of systemic lupus erythematosus: a provincial population-based study

Abstract Environmental exposures interact with genetic factors has been thought to influence susceptibility of systemic lupus erythematosus (SLE) development. To evaluate the effects of environmental exposures on SLE, we conducted a population-based cohort study across Jiangsu Province, China, to ex...

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Autores principales: Jiaqi Chen, Wenqiang Qu, Li Sun, Jiansheng Chen, Wei Kong, Fan Wang, Wenyou Pan, Lin Liu, Min Wu, Fuwan Ding, Huaixia Hu, Xiang Ding, Hua Wei, Yaohong Zou, Xian Qian, Meimei Wang, Jian Wu, Juan Tao, Jun Tan, Zhanyun Da, Miaojia Zhang, Jing Li, Jun Liang, Xuebing Feng, Linyu Geng, Lingyun Sun
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Publicado: Nature Portfolio 2021
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spelling oai:doaj.org-article:ab11cacbb0a643a7a8a02fa0c6e29e4e2021-12-02T17:27:03ZThe relationship of polluted air and drinking water sources with the prevalence of systemic lupus erythematosus: a provincial population-based study10.1038/s41598-021-98111-82045-2322https://doaj.org/article/ab11cacbb0a643a7a8a02fa0c6e29e4e2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98111-8https://doaj.org/toc/2045-2322Abstract Environmental exposures interact with genetic factors has been thought to influence susceptibility of systemic lupus erythematosus (SLE) development. To evaluate the effects of environmental exposures on SLE, we conducted a population-based cohort study across Jiangsu Province, China, to examine the associations between the living environment including air and water pollution, population density, economic income level, etc. and the prevalence and mortality of hospitalized SLE (h-SLE) patients. A total of 2231 h-SLE patients were retrieved from a longitudinal SLE database collected by the Jiangsu Lupus Collaborative Group from 1999 to 2009. The results showed that: It existed regional differences on the prevalence of h-SLE patients in 96 administrative districts; The distribution of NO2 air concentration monitored by atmospheric remote sensors showed that three of the ultra-high-prevalence districts were located in the concentrated chemical industry emission area; h-SLE patient prevalence was positively correlated with the excessive levels of nitrogen in drinking water; The positive ratio of pericarditis and proteinuria was positively correlated with the prevalence of h-SLE patients and pollution not only induced a high h-SLE patient prevalence but also a higher mortality rate, which might be attributed to NOx pollution in the air and drinking water. In summary, our data suggested that NOx in air and drinking water may be one of the important predispositions of SLE, especially for patients with renal involvement.Jiaqi ChenWenqiang QuLi SunJiansheng ChenWei KongFan WangWenyou PanLin LiuMin WuFuwan DingHuaixia HuXiang DingHua WeiYaohong ZouXian QianMeimei WangJian WuJuan TaoJun TanZhanyun DaMiaojia ZhangJing LiJun LiangXuebing FengLinyu GengLingyun SunNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Jiaqi Chen
Wenqiang Qu
Li Sun
Jiansheng Chen
Wei Kong
Fan Wang
Wenyou Pan
Lin Liu
Min Wu
Fuwan Ding
Huaixia Hu
Xiang Ding
Hua Wei
Yaohong Zou
Xian Qian
Meimei Wang
Jian Wu
Juan Tao
Jun Tan
Zhanyun Da
Miaojia Zhang
Jing Li
Jun Liang
Xuebing Feng
Linyu Geng
Lingyun Sun
The relationship of polluted air and drinking water sources with the prevalence of systemic lupus erythematosus: a provincial population-based study
description Abstract Environmental exposures interact with genetic factors has been thought to influence susceptibility of systemic lupus erythematosus (SLE) development. To evaluate the effects of environmental exposures on SLE, we conducted a population-based cohort study across Jiangsu Province, China, to examine the associations between the living environment including air and water pollution, population density, economic income level, etc. and the prevalence and mortality of hospitalized SLE (h-SLE) patients. A total of 2231 h-SLE patients were retrieved from a longitudinal SLE database collected by the Jiangsu Lupus Collaborative Group from 1999 to 2009. The results showed that: It existed regional differences on the prevalence of h-SLE patients in 96 administrative districts; The distribution of NO2 air concentration monitored by atmospheric remote sensors showed that three of the ultra-high-prevalence districts were located in the concentrated chemical industry emission area; h-SLE patient prevalence was positively correlated with the excessive levels of nitrogen in drinking water; The positive ratio of pericarditis and proteinuria was positively correlated with the prevalence of h-SLE patients and pollution not only induced a high h-SLE patient prevalence but also a higher mortality rate, which might be attributed to NOx pollution in the air and drinking water. In summary, our data suggested that NOx in air and drinking water may be one of the important predispositions of SLE, especially for patients with renal involvement.
format article
author Jiaqi Chen
Wenqiang Qu
Li Sun
Jiansheng Chen
Wei Kong
Fan Wang
Wenyou Pan
Lin Liu
Min Wu
Fuwan Ding
Huaixia Hu
Xiang Ding
Hua Wei
Yaohong Zou
Xian Qian
Meimei Wang
Jian Wu
Juan Tao
Jun Tan
Zhanyun Da
Miaojia Zhang
Jing Li
Jun Liang
Xuebing Feng
Linyu Geng
Lingyun Sun
author_facet Jiaqi Chen
Wenqiang Qu
Li Sun
Jiansheng Chen
Wei Kong
Fan Wang
Wenyou Pan
Lin Liu
Min Wu
Fuwan Ding
Huaixia Hu
Xiang Ding
Hua Wei
Yaohong Zou
Xian Qian
Meimei Wang
Jian Wu
Juan Tao
Jun Tan
Zhanyun Da
Miaojia Zhang
Jing Li
Jun Liang
Xuebing Feng
Linyu Geng
Lingyun Sun
author_sort Jiaqi Chen
title The relationship of polluted air and drinking water sources with the prevalence of systemic lupus erythematosus: a provincial population-based study
title_short The relationship of polluted air and drinking water sources with the prevalence of systemic lupus erythematosus: a provincial population-based study
title_full The relationship of polluted air and drinking water sources with the prevalence of systemic lupus erythematosus: a provincial population-based study
title_fullStr The relationship of polluted air and drinking water sources with the prevalence of systemic lupus erythematosus: a provincial population-based study
title_full_unstemmed The relationship of polluted air and drinking water sources with the prevalence of systemic lupus erythematosus: a provincial population-based study
title_sort relationship of polluted air and drinking water sources with the prevalence of systemic lupus erythematosus: a provincial population-based study
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/ab11cacbb0a643a7a8a02fa0c6e29e4e
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