Targeting integrin αvβ3 by a rationally designed protein for chronic liver disease treatment

As activated hepatic stellate cells and liver sinusoidal endothelial cells express high levels of integrin α v β3, Turaga et al. present a strategy for treatment of chronic liver disease using their rationally designed protein (ProAgio) which targets integrin α v β3. They find that ProAgio –mediated...

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Autores principales:	Ravi Chakra Turaga, Ganesh Satyanarayana, Malvika Sharma, Jenny J. Yang, Shiyuan Wang, Chunfeng Liu, Sun Li, Hua Yang, Hans Grossniklaus, Alton Brad Farris, Jordi Gracia-Sancho, Zhi-Ren Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ab156e8cd1c24f94ba28fcb876a8cb76
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spelling	oai:doaj.org-article:ab156e8cd1c24f94ba28fcb876a8cb762021-12-02T17:25:42ZTargeting integrin αvβ3 by a rationally designed protein for chronic liver disease treatment10.1038/s42003-021-02611-22399-3642https://doaj.org/article/ab156e8cd1c24f94ba28fcb876a8cb762021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02611-2https://doaj.org/toc/2399-3642As activated hepatic stellate cells and liver sinusoidal endothelial cells express high levels of integrin α v β3, Turaga et al. present a strategy for treatment of chronic liver disease using their rationally designed protein (ProAgio) which targets integrin α v β3. They find that ProAgio –mediated apoptosis of these disease-associated cells reverses liver fibrosis and ameliorates intrahepatic vascular resistance in a mouse modelRavi Chakra TuragaGanesh SatyanarayanaMalvika SharmaJenny J. YangShiyuan WangChunfeng LiuSun LiHua YangHans GrossniklausAlton Brad FarrisJordi Gracia-SanchoZhi-Ren LiuNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Ravi Chakra Turaga Ganesh Satyanarayana Malvika Sharma Jenny J. Yang Shiyuan Wang Chunfeng Liu Sun Li Hua Yang Hans Grossniklaus Alton Brad Farris Jordi Gracia-Sancho Zhi-Ren Liu Targeting integrin αvβ3 by a rationally designed protein for chronic liver disease treatment
description	As activated hepatic stellate cells and liver sinusoidal endothelial cells express high levels of integrin α v β3, Turaga et al. present a strategy for treatment of chronic liver disease using their rationally designed protein (ProAgio) which targets integrin α v β3. They find that ProAgio –mediated apoptosis of these disease-associated cells reverses liver fibrosis and ameliorates intrahepatic vascular resistance in a mouse model
format	article
author	Ravi Chakra Turaga Ganesh Satyanarayana Malvika Sharma Jenny J. Yang Shiyuan Wang Chunfeng Liu Sun Li Hua Yang Hans Grossniklaus Alton Brad Farris Jordi Gracia-Sancho Zhi-Ren Liu
author_facet	Ravi Chakra Turaga Ganesh Satyanarayana Malvika Sharma Jenny J. Yang Shiyuan Wang Chunfeng Liu Sun Li Hua Yang Hans Grossniklaus Alton Brad Farris Jordi Gracia-Sancho Zhi-Ren Liu
author_sort	Ravi Chakra Turaga
title	Targeting integrin αvβ3 by a rationally designed protein for chronic liver disease treatment
title_short	Targeting integrin αvβ3 by a rationally designed protein for chronic liver disease treatment
title_full	Targeting integrin αvβ3 by a rationally designed protein for chronic liver disease treatment
title_fullStr	Targeting integrin αvβ3 by a rationally designed protein for chronic liver disease treatment
title_full_unstemmed	Targeting integrin αvβ3 by a rationally designed protein for chronic liver disease treatment
title_sort	targeting integrin αvβ3 by a rationally designed protein for chronic liver disease treatment
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ab156e8cd1c24f94ba28fcb876a8cb76
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Targeting integrin αvβ3 by a rationally designed protein for chronic liver disease treatment

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