Determinants of left ventricular structure, filling and long axis function in systemic sclerosis.

<h4>Background</h4>Abnormalities of left ventricular (LV) structure, filling and long-axis function have all been reported in subjects with systemic sclerosis (SSc) and a normal LV ejection fraction (EF), but previous study findings have not been consistent. The aim of this study was to...

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Autores principales:	Roger E Peverill, Gene-Siew Ngian, Catherine Mylrea, Joanne Sahhar
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ab1834c02bce47d6960f1a204d04f65d
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spelling	oai:doaj.org-article:ab1834c02bce47d6960f1a204d04f65d2021-12-02T20:16:36ZDeterminants of left ventricular structure, filling and long axis function in systemic sclerosis.1932-620310.1371/journal.pone.0258593https://doaj.org/article/ab1834c02bce47d6960f1a204d04f65d2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258593https://doaj.org/toc/1932-6203<h4>Background</h4>Abnormalities of left ventricular (LV) structure, filling and long-axis function have all been reported in subjects with systemic sclerosis (SSc) and a normal LV ejection fraction (EF), but previous study findings have not been consistent. The aim of this study was to identify factors which could have confounded the analyses in previous studies of SSc, and in particular to consider the variables of body surface area (BSA), sex, age, heart rate, blood pressure (BP), disease duration (DD), disease type (limited versus diffuse) and interstitial lung disease (ILD).<h4>Methods</h4>Echocardiography was performed on 100 subjects with SSc (79 women; age 56±15 years) with a LVEF ≥50% and free of pulmonary arterial hypertension, coronary artery disease, more than mild valvular heart disease and atrial fibrillation. Measurements were performed of the LV end-diastolic dimension (LVEDD) and septal wall thickness (SWT), the transmitral Doppler E, A and deceleration time (DT), and the peak systolic (s') and early diastolic (e') LV long-axis velocities. Multivariate analyses were performed to investigate correlations of the above LV variables with BSA, sex, age, heart rate, BP, DD, disease type, and the presence of ILD.<h4>Results</h4>DD varied between 0.1 and 41.2 years, 25% had diffuse and 75% had limited disease, and 37% had ILD. SWT and LVEDD were positively correlated with BSA, SWT was also positively correlated with age and larger in males, and LVEDD was larger in diffuse disease. Age was positively correlated with A and DT, and inversely correlated with E and E/A, and heart rate was inversely correlated with E and E/A. None of E, A, E/A, or DT were independently associated with DD or disease type. Septal and lateral LV wall s' and e' were all inversely correlated with age, and there was a small independent contribution to the prediction of lateral s' from DD, but no association of either s' or e' with disease type. The presence of ILD was not a predictor of any of the LV variables.<h4>Conclusion</h4>In SSc there are associations of sex, body size, age and disease type with LV structural variables, of age and heart rate with E/A, and of age with both systolic and early diastolic LV long-axis velocities. Appropriate adjustment for these variables could help to resolve current uncertainties regarding SSc effects on the left ventricle.Roger E PeverillGene-Siew NgianCatherine MylreaJoanne SahharPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258593 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Roger E Peverill Gene-Siew Ngian Catherine Mylrea Joanne Sahhar Determinants of left ventricular structure, filling and long axis function in systemic sclerosis.
description	<h4>Background</h4>Abnormalities of left ventricular (LV) structure, filling and long-axis function have all been reported in subjects with systemic sclerosis (SSc) and a normal LV ejection fraction (EF), but previous study findings have not been consistent. The aim of this study was to identify factors which could have confounded the analyses in previous studies of SSc, and in particular to consider the variables of body surface area (BSA), sex, age, heart rate, blood pressure (BP), disease duration (DD), disease type (limited versus diffuse) and interstitial lung disease (ILD).<h4>Methods</h4>Echocardiography was performed on 100 subjects with SSc (79 women; age 56±15 years) with a LVEF ≥50% and free of pulmonary arterial hypertension, coronary artery disease, more than mild valvular heart disease and atrial fibrillation. Measurements were performed of the LV end-diastolic dimension (LVEDD) and septal wall thickness (SWT), the transmitral Doppler E, A and deceleration time (DT), and the peak systolic (s') and early diastolic (e') LV long-axis velocities. Multivariate analyses were performed to investigate correlations of the above LV variables with BSA, sex, age, heart rate, BP, DD, disease type, and the presence of ILD.<h4>Results</h4>DD varied between 0.1 and 41.2 years, 25% had diffuse and 75% had limited disease, and 37% had ILD. SWT and LVEDD were positively correlated with BSA, SWT was also positively correlated with age and larger in males, and LVEDD was larger in diffuse disease. Age was positively correlated with A and DT, and inversely correlated with E and E/A, and heart rate was inversely correlated with E and E/A. None of E, A, E/A, or DT were independently associated with DD or disease type. Septal and lateral LV wall s' and e' were all inversely correlated with age, and there was a small independent contribution to the prediction of lateral s' from DD, but no association of either s' or e' with disease type. The presence of ILD was not a predictor of any of the LV variables.<h4>Conclusion</h4>In SSc there are associations of sex, body size, age and disease type with LV structural variables, of age and heart rate with E/A, and of age with both systolic and early diastolic LV long-axis velocities. Appropriate adjustment for these variables could help to resolve current uncertainties regarding SSc effects on the left ventricle.
format	article
author	Roger E Peverill Gene-Siew Ngian Catherine Mylrea Joanne Sahhar
author_facet	Roger E Peverill Gene-Siew Ngian Catherine Mylrea Joanne Sahhar
author_sort	Roger E Peverill
title	Determinants of left ventricular structure, filling and long axis function in systemic sclerosis.
title_short	Determinants of left ventricular structure, filling and long axis function in systemic sclerosis.
title_full	Determinants of left ventricular structure, filling and long axis function in systemic sclerosis.
title_fullStr	Determinants of left ventricular structure, filling and long axis function in systemic sclerosis.
title_full_unstemmed	Determinants of left ventricular structure, filling and long axis function in systemic sclerosis.
title_sort	determinants of left ventricular structure, filling and long axis function in systemic sclerosis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/ab1834c02bce47d6960f1a204d04f65d
work_keys_str_mv	AT rogerepeverill determinantsofleftventricularstructurefillingandlongaxisfunctioninsystemicsclerosis AT genesiewngian determinantsofleftventricularstructurefillingandlongaxisfunctioninsystemicsclerosis AT catherinemylrea determinantsofleftventricularstructurefillingandlongaxisfunctioninsystemicsclerosis AT joannesahhar determinantsofleftventricularstructurefillingandlongaxisfunctioninsystemicsclerosis
_version_	1718374487317020672

Determinants of left ventricular structure, filling and long axis function in systemic sclerosis.

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