Quantifying protein dynamics and stability in a living organism

Studying protein kinetics and stability in living organisms is challenging and most studies are performed in cell culture. Here the authors combine meganuclease-mediated transformation and fluorescence-detected temperature-jump microscopy to quantify protein stability in different tissues of living...

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Autores principales:	Ruopei Feng, Martin Gruebele, Caitlin M. Davis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ab1a9da76c7a4019856d44a01cb0d86b
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spelling	oai:doaj.org-article:ab1a9da76c7a4019856d44a01cb0d86b2021-12-02T16:58:25ZQuantifying protein dynamics and stability in a living organism10.1038/s41467-019-09088-y2041-1723https://doaj.org/article/ab1a9da76c7a4019856d44a01cb0d86b2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09088-yhttps://doaj.org/toc/2041-1723Studying protein kinetics and stability in living organisms is challenging and most studies are performed in cell culture. Here the authors combine meganuclease-mediated transformation and fluorescence-detected temperature-jump microscopy to quantify protein stability in different tissues of living zebrafish.Ruopei FengMartin GruebeleCaitlin M. DavisNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ruopei Feng Martin Gruebele Caitlin M. Davis Quantifying protein dynamics and stability in a living organism
description	Studying protein kinetics and stability in living organisms is challenging and most studies are performed in cell culture. Here the authors combine meganuclease-mediated transformation and fluorescence-detected temperature-jump microscopy to quantify protein stability in different tissues of living zebrafish.
format	article
author	Ruopei Feng Martin Gruebele Caitlin M. Davis
author_facet	Ruopei Feng Martin Gruebele Caitlin M. Davis
author_sort	Ruopei Feng
title	Quantifying protein dynamics and stability in a living organism
title_short	Quantifying protein dynamics and stability in a living organism
title_full	Quantifying protein dynamics and stability in a living organism
title_fullStr	Quantifying protein dynamics and stability in a living organism
title_full_unstemmed	Quantifying protein dynamics and stability in a living organism
title_sort	quantifying protein dynamics and stability in a living organism
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ab1a9da76c7a4019856d44a01cb0d86b
work_keys_str_mv	AT ruopeifeng quantifyingproteindynamicsandstabilityinalivingorganism AT martingruebele quantifyingproteindynamicsandstabilityinalivingorganism AT caitlinmdavis quantifyingproteindynamicsandstabilityinalivingorganism
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Quantifying protein dynamics and stability in a living organism

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