Vitamin D Insufficiency in Disease Severity and Prognosis of the Patients with SARS Corona Virus-2 Infection
Bachground: The global crisis caused by the SARS Corona virus-2 infection is continuing through 2021, with more than 3.5 million deaths. Several risk factors for this virus’s severity and death were documented, including diabetes, hypertension, and ischemic heart disease. Objectives: To evaluate...
Guardado en:
| Autores principales: | , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Tehran University of Medical Sciences
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/ab1d574e7f444d65840b4962744a8b54 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| Sumario: | Bachground: The global crisis caused by the SARS Corona virus-2 infection is continuing through 2021, with more than 3.5 million deaths. Several risk factors for this virus’s severity and death were documented, including diabetes, hypertension, and ischemic heart disease.
Objectives: To evaluate the relation between serum vitamin D3 level, the disease severity, and prognosis of the patients with SARS Corona virus-2 infection.
Methods: Patients with COVID-19 were evaluated for serum vitamin D levels and laboratory data. Correlation between vitamin D levels and laboratory data with disease severity and prognosis was assessed. Cox and logistic regression tests as well as ROC curve were used for data analysis.
Results: ninety-eight patients with Corona virus-2 disease (COVID-19) which consisted of sixty patients with moderate COVID-19 in the general wards, and thirty-eight patients with severe COVID-19 in the intensive care unit (ICU) were evaluated. The mean age in the general wards was lower than in ICU (60.96 ± 14.86 compared to 67.94 ± 16.46, P=0.001), and the mean serum vitamin D level in the patients admitted in the general wards was higher than in the ICU (31 ng / mL compared 20.57 ng / mL, P = 0.003). In addition, vitamin D deficiency (25(OH) D < 25 ng/mL) was associated with a significant increase in the risk of severe disease (odds ratio=2.91 , P=0.019) and mortality (odds ratio=3.64 , P=0.026).
Conclusion: Vitamin D deficiency is a risk factor for disease severity and poor prognosis in COVID-19.Vitamin D level of 25 ng/mL can be used as a cut-off value for predicting severity and prognosis. |
|---|