Vitamin D Insufficiency in Disease Severity and Prognosis of the Patients with SARS Corona Virus-2 Infection

Bachground: The global crisis caused by the SARS Corona virus-2 infection is continuing through 2021, with more than 3.5 million deaths. Several risk factors for this virus’s severity and death were documented, including diabetes, hypertension, and ischemic heart disease. Objectives: To evaluate...

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Autores principales:	Ali Asgari, Ebrahim Hazrati, Saeed Soleiman-Meigooni, Mohsen Rajaeinejad, sam Alahyari, Malihe Nasiri
Formato:	article
Lenguaje:	EN
Publicado:	Tehran University of Medical Sciences 2021
Materias:	covid-19 prognosis risk factor sars-cov-2 severity vitamin d Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ab1d574e7f444d65840b4962744a8b54
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spelling	oai:doaj.org-article:ab1d574e7f444d65840b4962744a8b542021-11-29T06:16:20ZVitamin D Insufficiency in Disease Severity and Prognosis of the Patients with SARS Corona Virus-2 Infection0044-60251735-969410.18502/acta.v59i11.7779https://doaj.org/article/ab1d574e7f444d65840b4962744a8b542021-11-01T00:00:00Zhttps://acta.tums.ac.ir/index.php/acta/article/view/9507https://doaj.org/toc/0044-6025https://doaj.org/toc/1735-9694Bachground: The global crisis caused by the SARS Corona virus-2 infection is continuing through 2021, with more than 3.5 million deaths. Several risk factors for this virus’s severity and death were documented, including diabetes, hypertension, and ischemic heart disease. Objectives: To evaluate the relation between serum vitamin D3 level, the disease severity, and prognosis of the patients with SARS Corona virus-2 infection. Methods: Patients with COVID-19 were evaluated for serum vitamin D levels and laboratory data. Correlation between vitamin D levels and laboratory data with disease severity and prognosis was assessed. Cox and logistic regression tests as well as ROC curve were used for data analysis. Results: ninety-eight patients with Corona virus-2 disease (COVID-19) which consisted of sixty patients with moderate COVID-19 in the general wards, and thirty-eight patients with severe COVID-19 in the intensive care unit (ICU) were evaluated. The mean age in the general wards was lower than in ICU (60.96 ± 14.86 compared to 67.94 ± 16.46, P=0.001), and the mean serum vitamin D level in the patients admitted in the general wards was higher than in the ICU (31 ng / mL compared 20.57 ng / mL, P = 0.003). In addition, vitamin D deficiency (25(OH) D < 25 ng/mL) was associated with a significant increase in the risk of severe disease (odds ratio=2.91 , P=0.019) and mortality (odds ratio=3.64 , P=0.026). Conclusion: Vitamin D deficiency is a risk factor for disease severity and poor prognosis in COVID-19.Vitamin D level of 25 ng/mL can be used as a cut-off value for predicting severity and prognosis.Ali AsgariEbrahim HazratiSaeed Soleiman-MeigooniMohsen Rajaeinejadsam AlahyariMalihe NasiriTehran University of Medical Sciencesarticlecovid-19prognosisrisk factorsars-cov-2severityvitamin dMedicine (General)R5-920ENActa Medica Iranica, Pp 662-668 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	covid-19 prognosis risk factor sars-cov-2 severity vitamin d Medicine (General) R5-920
spellingShingle	covid-19 prognosis risk factor sars-cov-2 severity vitamin d Medicine (General) R5-920 Ali Asgari Ebrahim Hazrati Saeed Soleiman-Meigooni Mohsen Rajaeinejad sam Alahyari Malihe Nasiri Vitamin D Insufficiency in Disease Severity and Prognosis of the Patients with SARS Corona Virus-2 Infection
description	Bachground: The global crisis caused by the SARS Corona virus-2 infection is continuing through 2021, with more than 3.5 million deaths. Several risk factors for this virus’s severity and death were documented, including diabetes, hypertension, and ischemic heart disease. Objectives: To evaluate the relation between serum vitamin D3 level, the disease severity, and prognosis of the patients with SARS Corona virus-2 infection. Methods: Patients with COVID-19 were evaluated for serum vitamin D levels and laboratory data. Correlation between vitamin D levels and laboratory data with disease severity and prognosis was assessed. Cox and logistic regression tests as well as ROC curve were used for data analysis. Results: ninety-eight patients with Corona virus-2 disease (COVID-19) which consisted of sixty patients with moderate COVID-19 in the general wards, and thirty-eight patients with severe COVID-19 in the intensive care unit (ICU) were evaluated. The mean age in the general wards was lower than in ICU (60.96 ± 14.86 compared to 67.94 ± 16.46, P=0.001), and the mean serum vitamin D level in the patients admitted in the general wards was higher than in the ICU (31 ng / mL compared 20.57 ng / mL, P = 0.003). In addition, vitamin D deficiency (25(OH) D < 25 ng/mL) was associated with a significant increase in the risk of severe disease (odds ratio=2.91 , P=0.019) and mortality (odds ratio=3.64 , P=0.026). Conclusion: Vitamin D deficiency is a risk factor for disease severity and poor prognosis in COVID-19.Vitamin D level of 25 ng/mL can be used as a cut-off value for predicting severity and prognosis.
format	article
author	Ali Asgari Ebrahim Hazrati Saeed Soleiman-Meigooni Mohsen Rajaeinejad sam Alahyari Malihe Nasiri
author_facet	Ali Asgari Ebrahim Hazrati Saeed Soleiman-Meigooni Mohsen Rajaeinejad sam Alahyari Malihe Nasiri
author_sort	Ali Asgari
title	Vitamin D Insufficiency in Disease Severity and Prognosis of the Patients with SARS Corona Virus-2 Infection
title_short	Vitamin D Insufficiency in Disease Severity and Prognosis of the Patients with SARS Corona Virus-2 Infection
title_full	Vitamin D Insufficiency in Disease Severity and Prognosis of the Patients with SARS Corona Virus-2 Infection
title_fullStr	Vitamin D Insufficiency in Disease Severity and Prognosis of the Patients with SARS Corona Virus-2 Infection
title_full_unstemmed	Vitamin D Insufficiency in Disease Severity and Prognosis of the Patients with SARS Corona Virus-2 Infection
title_sort	vitamin d insufficiency in disease severity and prognosis of the patients with sars corona virus-2 infection
publisher	Tehran University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/ab1d574e7f444d65840b4962744a8b54
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Vitamin D Insufficiency in Disease Severity and Prognosis of the Patients with SARS Corona Virus-2 Infection

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