G-quadruplexes originating from evolutionary conserved L1 elements interfere with neuronal gene expression in Alzheimer’s disease

G-quadruplexes (G4) can be formed from DNA sequences containing consecutive guanines organized in 4-interspaced tandem repeats. Here the authors reveal the association between G4 structures present at specific loci in Alzheimer’s disease neurons and reduced gene expression and perturbed alternative...

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Autores principales:	Roy Hanna, Anthony Flamier, Andrea Barabino, Gilbert Bernier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ab1da85a22b64ec3b012eb44668f6c59
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spelling	oai:doaj.org-article:ab1da85a22b64ec3b012eb44668f6c592021-12-02T17:04:31ZG-quadruplexes originating from evolutionary conserved L1 elements interfere with neuronal gene expression in Alzheimer’s disease10.1038/s41467-021-22129-92041-1723https://doaj.org/article/ab1da85a22b64ec3b012eb44668f6c592021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22129-9https://doaj.org/toc/2041-1723G-quadruplexes (G4) can be formed from DNA sequences containing consecutive guanines organized in 4-interspaced tandem repeats. Here the authors reveal the association between G4 structures present at specific loci in Alzheimer’s disease neurons and reduced gene expression and perturbed alternative splicing.Roy HannaAnthony FlamierAndrea BarabinoGilbert BernierNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Roy Hanna Anthony Flamier Andrea Barabino Gilbert Bernier G-quadruplexes originating from evolutionary conserved L1 elements interfere with neuronal gene expression in Alzheimer’s disease
description	G-quadruplexes (G4) can be formed from DNA sequences containing consecutive guanines organized in 4-interspaced tandem repeats. Here the authors reveal the association between G4 structures present at specific loci in Alzheimer’s disease neurons and reduced gene expression and perturbed alternative splicing.
format	article
author	Roy Hanna Anthony Flamier Andrea Barabino Gilbert Bernier
author_facet	Roy Hanna Anthony Flamier Andrea Barabino Gilbert Bernier
author_sort	Roy Hanna
title	G-quadruplexes originating from evolutionary conserved L1 elements interfere with neuronal gene expression in Alzheimer’s disease
title_short	G-quadruplexes originating from evolutionary conserved L1 elements interfere with neuronal gene expression in Alzheimer’s disease
title_full	G-quadruplexes originating from evolutionary conserved L1 elements interfere with neuronal gene expression in Alzheimer’s disease
title_fullStr	G-quadruplexes originating from evolutionary conserved L1 elements interfere with neuronal gene expression in Alzheimer’s disease
title_full_unstemmed	G-quadruplexes originating from evolutionary conserved L1 elements interfere with neuronal gene expression in Alzheimer’s disease
title_sort	g-quadruplexes originating from evolutionary conserved l1 elements interfere with neuronal gene expression in alzheimer’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ab1da85a22b64ec3b012eb44668f6c59
work_keys_str_mv	AT royhanna gquadruplexesoriginatingfromevolutionaryconservedl1elementsinterferewithneuronalgeneexpressioninalzheimersdisease AT anthonyflamier gquadruplexesoriginatingfromevolutionaryconservedl1elementsinterferewithneuronalgeneexpressioninalzheimersdisease AT andreabarabino gquadruplexesoriginatingfromevolutionaryconservedl1elementsinterferewithneuronalgeneexpressioninalzheimersdisease AT gilbertbernier gquadruplexesoriginatingfromevolutionaryconservedl1elementsinterferewithneuronalgeneexpressioninalzheimersdisease
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G-quadruplexes originating from evolutionary conserved L1 elements interfere with neuronal gene expression in Alzheimer’s disease

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