The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis

The deubiquitylase OTUD3 can function as a tumour-suppressor by stabilizing PTEN. Here, the authors show that OTUD3 also has an oncogenic role in lung cancer by stabilizing the glucose-regulated protein GRP78.

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Autores principales:	Tongde Du, Hongchang Li, Yongsheng Fan, Lin Yuan, Xiaodan Guo, Qiong Zhu, Yuying Yao, Xin Li, Chunlei Liu, Xinhe Yu, Zhaofei Liu, Chun-Ping Cui, Chuanchun Han, Lingqiang Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ab1f8b5e1844405cb2061fdd5a0b4699
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spelling	oai:doaj.org-article:ab1f8b5e1844405cb2061fdd5a0b46992021-12-02T17:32:24ZThe deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis10.1038/s41467-019-10824-72041-1723https://doaj.org/article/ab1f8b5e1844405cb2061fdd5a0b46992019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10824-7https://doaj.org/toc/2041-1723The deubiquitylase OTUD3 can function as a tumour-suppressor by stabilizing PTEN. Here, the authors show that OTUD3 also has an oncogenic role in lung cancer by stabilizing the glucose-regulated protein GRP78.Tongde DuHongchang LiYongsheng FanLin YuanXiaodan GuoQiong ZhuYuying YaoXin LiChunlei LiuXinhe YuZhaofei LiuChun-Ping CuiChuanchun HanLingqiang ZhangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tongde Du Hongchang Li Yongsheng Fan Lin Yuan Xiaodan Guo Qiong Zhu Yuying Yao Xin Li Chunlei Liu Xinhe Yu Zhaofei Liu Chun-Ping Cui Chuanchun Han Lingqiang Zhang The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis
description	The deubiquitylase OTUD3 can function as a tumour-suppressor by stabilizing PTEN. Here, the authors show that OTUD3 also has an oncogenic role in lung cancer by stabilizing the glucose-regulated protein GRP78.
format	article
author	Tongde Du Hongchang Li Yongsheng Fan Lin Yuan Xiaodan Guo Qiong Zhu Yuying Yao Xin Li Chunlei Liu Xinhe Yu Zhaofei Liu Chun-Ping Cui Chuanchun Han Lingqiang Zhang
author_facet	Tongde Du Hongchang Li Yongsheng Fan Lin Yuan Xiaodan Guo Qiong Zhu Yuying Yao Xin Li Chunlei Liu Xinhe Yu Zhaofei Liu Chun-Ping Cui Chuanchun Han Lingqiang Zhang
author_sort	Tongde Du
title	The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis
title_short	The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis
title_full	The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis
title_fullStr	The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis
title_full_unstemmed	The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis
title_sort	deubiquitylase otud3 stabilizes grp78 and promotes lung tumorigenesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ab1f8b5e1844405cb2061fdd5a0b4699
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The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis

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