The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis

The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis

The deubiquitylase OTUD3 can function as a tumour-suppressor by stabilizing PTEN. Here, the authors show that OTUD3 also has an oncogenic role in lung cancer by stabilizing the glucose-regulated protein GRP78.

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Bibliographic Details
Main Authors: Tongde Du, Hongchang Li, Yongsheng Fan, Lin Yuan, Xiaodan Guo, Qiong Zhu, Yuying Yao, Xin Li, Chunlei Liu, Xinhe Yu, Zhaofei Liu, Chun-Ping Cui, Chuanchun Han, Lingqiang Zhang
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
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Online Access:https://doaj.org/article/ab1f8b5e1844405cb2061fdd5a0b4699
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