The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation

T cells can alter their metabolism during activation and differentiation. Here the authors show that the tumor suppressor menin regulates CD8 T-cell fate via the modulation of central carbon metabolism.

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Autores principales:	Junpei Suzuki, Takeshi Yamada, Kazuki Inoue, Shogo Nabe, Makoto Kuwahara, Nobuaki Takemori, Ayako Takemori, Seiji Matsuda, Makoto Kanoh, Yuuki Imai, Masaki Yasukawa, Masakatsu Yamashita
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ab20cf83169f418bb4198a412fbc757d
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spelling	oai:doaj.org-article:ab20cf83169f418bb4198a412fbc757d2021-12-02T17:31:57ZThe tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation10.1038/s41467-018-05854-62041-1723https://doaj.org/article/ab20cf83169f418bb4198a412fbc757d2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05854-6https://doaj.org/toc/2041-1723T cells can alter their metabolism during activation and differentiation. Here the authors show that the tumor suppressor menin regulates CD8 T-cell fate via the modulation of central carbon metabolism.Junpei SuzukiTakeshi YamadaKazuki InoueShogo NabeMakoto KuwaharaNobuaki TakemoriAyako TakemoriSeiji MatsudaMakoto KanohYuuki ImaiMasaki YasukawaMasakatsu YamashitaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Junpei Suzuki Takeshi Yamada Kazuki Inoue Shogo Nabe Makoto Kuwahara Nobuaki Takemori Ayako Takemori Seiji Matsuda Makoto Kanoh Yuuki Imai Masaki Yasukawa Masakatsu Yamashita The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation
description	T cells can alter their metabolism during activation and differentiation. Here the authors show that the tumor suppressor menin regulates CD8 T-cell fate via the modulation of central carbon metabolism.
format	article
author	Junpei Suzuki Takeshi Yamada Kazuki Inoue Shogo Nabe Makoto Kuwahara Nobuaki Takemori Ayako Takemori Seiji Matsuda Makoto Kanoh Yuuki Imai Masaki Yasukawa Masakatsu Yamashita
author_facet	Junpei Suzuki Takeshi Yamada Kazuki Inoue Shogo Nabe Makoto Kuwahara Nobuaki Takemori Ayako Takemori Seiji Matsuda Makoto Kanoh Yuuki Imai Masaki Yasukawa Masakatsu Yamashita
author_sort	Junpei Suzuki
title	The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation
title_short	The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation
title_full	The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation
title_fullStr	The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation
title_full_unstemmed	The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation
title_sort	tumor suppressor menin prevents effector cd8 t-cell dysfunction by targeting mtorc1-dependent metabolic activation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ab20cf83169f418bb4198a412fbc757d
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The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation

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