Reduced expression of the ROCK inhibitor Rnd3 is associated with increased invasiveness and metastatic potential in mesenchymal tumor cells.

<h4>Background</h4>Mesenchymal and amoeboid movements are two important mechanisms adopted by cancer cells to invade the surrounding environment. Mesenchymal movement depends on extracellular matrix protease activity, amoeboid movement on the RhoA-dependent kinase ROCK. Cancer cells can...

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Autores principales: Cristina Belgiovine, Roberta Frapolli, Katiuscia Bonezzi, Ilaria Chiodi, Francesco Favero, Maurizia Mello-Grand, Angelo P Dei Tos, Elena Giulotto, Giulia Taraboletti, Maurizio D'Incalci, Chiara Mondello
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
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Acceso en línea:https://doaj.org/article/ab26f552175c4a31926a567953d3f219
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