Attention, cognitive control and motivation in ADHD: Linking event-related brain potentials and DNA methylation patterns in boys at early school age

Abstract In order to better understand the underpinnings of attention-deficit/hyperactivity disorder (ADHD), we targeted the relationship of attentional, cognitive control and motivational processes with DNA methylation patterns of 60 candidate genes in boys at early school age. Participants (6 to 8...

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Autores principales:	Hartmut Heinrich, Juliane Grunitz, Valeska Stonawski, Stefan Frey, Simone Wahl, Björn Albrecht, Tamme W. Goecke, Matthias W. Beckmann, Johannes Kornhuber, Peter A. Fasching, Gunther H. Moll, Anna Eichler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ab2a474178f541bc8cdba5ad566436e0
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spelling	oai:doaj.org-article:ab2a474178f541bc8cdba5ad566436e02021-12-02T11:40:50ZAttention, cognitive control and motivation in ADHD: Linking event-related brain potentials and DNA methylation patterns in boys at early school age10.1038/s41598-017-03326-32045-2322https://doaj.org/article/ab2a474178f541bc8cdba5ad566436e02017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03326-3https://doaj.org/toc/2045-2322Abstract In order to better understand the underpinnings of attention-deficit/hyperactivity disorder (ADHD), we targeted the relationship of attentional, cognitive control and motivational processes with DNA methylation patterns of 60 candidate genes in boys at early school age. Participants (6 to 8 years; N = 82) were selected from a German longitudinal cohort (FRANCES). ADHD-related behaviour was assessed via maternal ratings. Performance and event-related potential measures (inter alia Cue-P3 and Nogo-P3), which were recorded in a motivational go/nogo task, indicated diminished attentional orienting, reduced inhibitory response control and a larger motivational effect on performance in ADHD already at this relatively young age. Methylation patterns were analysed in buccal cell DNA with the Illumina HumanMethylation 450K array. For CpG sites at genes of the dopaminergic (COMT, ANKK1) and the neurotrophic (BDNF, NGFR) system, associations with the Nogo-P3 as well as ADHD symptom severity were found suggesting that these systems are involved in response control deficits in ADHD. Methylation effects related to both functional aspects and ADHD behaviour were also observed for DPP10 and TPH2. Epigenetic mechanisms may play a role in ADHD-associated deficits but findings need to be replicated in larger samples and are limited by the fact that only peripheral methylation could be considered.Hartmut HeinrichJuliane GrunitzValeska StonawskiStefan FreySimone WahlBjörn AlbrechtTamme W. GoeckeMatthias W. BeckmannJohannes KornhuberPeter A. FaschingGunther H. MollAnna EichlerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hartmut Heinrich Juliane Grunitz Valeska Stonawski Stefan Frey Simone Wahl Björn Albrecht Tamme W. Goecke Matthias W. Beckmann Johannes Kornhuber Peter A. Fasching Gunther H. Moll Anna Eichler Attention, cognitive control and motivation in ADHD: Linking event-related brain potentials and DNA methylation patterns in boys at early school age
description	Abstract In order to better understand the underpinnings of attention-deficit/hyperactivity disorder (ADHD), we targeted the relationship of attentional, cognitive control and motivational processes with DNA methylation patterns of 60 candidate genes in boys at early school age. Participants (6 to 8 years; N = 82) were selected from a German longitudinal cohort (FRANCES). ADHD-related behaviour was assessed via maternal ratings. Performance and event-related potential measures (inter alia Cue-P3 and Nogo-P3), which were recorded in a motivational go/nogo task, indicated diminished attentional orienting, reduced inhibitory response control and a larger motivational effect on performance in ADHD already at this relatively young age. Methylation patterns were analysed in buccal cell DNA with the Illumina HumanMethylation 450K array. For CpG sites at genes of the dopaminergic (COMT, ANKK1) and the neurotrophic (BDNF, NGFR) system, associations with the Nogo-P3 as well as ADHD symptom severity were found suggesting that these systems are involved in response control deficits in ADHD. Methylation effects related to both functional aspects and ADHD behaviour were also observed for DPP10 and TPH2. Epigenetic mechanisms may play a role in ADHD-associated deficits but findings need to be replicated in larger samples and are limited by the fact that only peripheral methylation could be considered.
format	article
author	Hartmut Heinrich Juliane Grunitz Valeska Stonawski Stefan Frey Simone Wahl Björn Albrecht Tamme W. Goecke Matthias W. Beckmann Johannes Kornhuber Peter A. Fasching Gunther H. Moll Anna Eichler
author_facet	Hartmut Heinrich Juliane Grunitz Valeska Stonawski Stefan Frey Simone Wahl Björn Albrecht Tamme W. Goecke Matthias W. Beckmann Johannes Kornhuber Peter A. Fasching Gunther H. Moll Anna Eichler
author_sort	Hartmut Heinrich
title	Attention, cognitive control and motivation in ADHD: Linking event-related brain potentials and DNA methylation patterns in boys at early school age
title_short	Attention, cognitive control and motivation in ADHD: Linking event-related brain potentials and DNA methylation patterns in boys at early school age
title_full	Attention, cognitive control and motivation in ADHD: Linking event-related brain potentials and DNA methylation patterns in boys at early school age
title_fullStr	Attention, cognitive control and motivation in ADHD: Linking event-related brain potentials and DNA methylation patterns in boys at early school age
title_full_unstemmed	Attention, cognitive control and motivation in ADHD: Linking event-related brain potentials and DNA methylation patterns in boys at early school age
title_sort	attention, cognitive control and motivation in adhd: linking event-related brain potentials and dna methylation patterns in boys at early school age
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ab2a474178f541bc8cdba5ad566436e0
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Attention, cognitive control and motivation in ADHD: Linking event-related brain potentials and DNA methylation patterns in boys at early school age

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