Zinc downregulates HIF-1α and inhibits its activity in tumor cells in vitro and in vivo.

Zinc downregulates HIF-1α and inhibits its activity in tumor cells in vitro and in vivo.

<h4>Background</h4>Hypoxia inducible factor-1α (HIF-1α) is responsible for the majority of HIF-1-induced gene expression changes under hypoxia and for the "angiogenic switch" during tumor progression. HIF-1α is often upregulated in tumors leading to more aggressive tumor growth...

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Main Authors: Lavinia Nardinocchi, Valentina Pantisano, Rosa Puca, Manuela Porru, Aurora Aiello, Annalisa Grasselli, Carlo Leonetti, Michal Safran, Gideon Rechavi, David Givol, Antonella Farsetti, Gabriella D'Orazi
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2010
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/ab2a4d89211047d4bc42ddf4cf41d1bc
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