Protective effects of cerium oxide nanoparticles in non-alcoholic fatty liver disease (NAFLD) and carbon tetrachloride-induced liver damage in rats: Study on intestine and liver

Background and aims: Nanoparticles could represent a therapeutic approach for the treatment of various diseases. It has been reported that cerium oxide nanoparticles (CeO2 NPs) have potential useful effects. Therefore, we aimed to examine the protective effects of the CeO2 NPs in two models of liver...

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Autores principales:	Ebrahim Abbasi, Seyed Alireza Vafaei, Nima Naseri, Ali Darini, Masoumeh Taheri Azandaryani, Farhad Kian Ara, Fatemeh Mirzaei
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Cerium oxide nanoparticles Liver injury Inflammation Rats Carbon tetrachloride Physiology QP1-981 Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/ab2afab59d974fb78691e52ab31c4a99
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spelling	oai:doaj.org-article:ab2afab59d974fb78691e52ab31c4a992021-11-24T04:33:47ZProtective effects of cerium oxide nanoparticles in non-alcoholic fatty liver disease (NAFLD) and carbon tetrachloride-induced liver damage in rats: Study on intestine and liver2589-936810.1016/j.metop.2021.100151https://doaj.org/article/ab2afab59d974fb78691e52ab31c4a992021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S258993682100075Xhttps://doaj.org/toc/2589-9368Background and aims: Nanoparticles could represent a therapeutic approach for the treatment of various diseases. It has been reported that cerium oxide nanoparticles (CeO2 NPs) have potential useful effects. Therefore, we aimed to examine the protective effects of the CeO2 NPs in two models of liver injury, non-alcoholic fatty liver disease (NAFLD) and carbon tetrachloride (CCl4)-induced liver fibrosis, in rats. Methods: In this experimental study, male rats were randomly divided into different experimental groups including: Experiment 1; group1: healthy rats received normal saline, 2: CCl4 group, 3: CCl4 + nanoparticle. Experiment 2; group1: healthy rats received chow diet, 2: NAFLD group, 3: NAFLD + nanoparticle. The oxidative stress markers were determined in the liver and intestine. Tumor necrosis factor-α (TNF-α) levels were measured by ELISA. Histopathological changes of liver and intestine were evaluated by light microspore. Results: Total antioxidant capacity (TAC) and glutathione (GSH) levels significantly decreased, while malondialdehyde (MDA) and total oxidant status (TOS) were significantly increased in the liver, and intestine of the NAFLD and CCl4 group compared with control rats. However, the use of nanoparticles significantly normalized these markers. The levels of the TNF-α were significantly reduced in the nanoparticle group as compared with NAFLD model and CCl4-treated rats. CeO2 NPs also normalized the liver and intestinal histological changes. Conclusions: Our finding revealed that CeO2 NPs has potential protective effects by increasing antioxidant activity, and reducing inflammation.Ebrahim AbbasiSeyed Alireza VafaeiNima NaseriAli DariniMasoumeh Taheri AzandaryaniFarhad Kian AraFatemeh MirzaeiElsevierarticleCerium oxide nanoparticlesLiver injuryInflammationRatsCarbon tetrachloridePhysiologyQP1-981BiochemistryQD415-436ENMetabolism Open, Vol 12, Iss , Pp 100151- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cerium oxide nanoparticles Liver injury Inflammation Rats Carbon tetrachloride Physiology QP1-981 Biochemistry QD415-436
spellingShingle	Cerium oxide nanoparticles Liver injury Inflammation Rats Carbon tetrachloride Physiology QP1-981 Biochemistry QD415-436 Ebrahim Abbasi Seyed Alireza Vafaei Nima Naseri Ali Darini Masoumeh Taheri Azandaryani Farhad Kian Ara Fatemeh Mirzaei Protective effects of cerium oxide nanoparticles in non-alcoholic fatty liver disease (NAFLD) and carbon tetrachloride-induced liver damage in rats: Study on intestine and liver
description	Background and aims: Nanoparticles could represent a therapeutic approach for the treatment of various diseases. It has been reported that cerium oxide nanoparticles (CeO2 NPs) have potential useful effects. Therefore, we aimed to examine the protective effects of the CeO2 NPs in two models of liver injury, non-alcoholic fatty liver disease (NAFLD) and carbon tetrachloride (CCl4)-induced liver fibrosis, in rats. Methods: In this experimental study, male rats were randomly divided into different experimental groups including: Experiment 1; group1: healthy rats received normal saline, 2: CCl4 group, 3: CCl4 + nanoparticle. Experiment 2; group1: healthy rats received chow diet, 2: NAFLD group, 3: NAFLD + nanoparticle. The oxidative stress markers were determined in the liver and intestine. Tumor necrosis factor-α (TNF-α) levels were measured by ELISA. Histopathological changes of liver and intestine were evaluated by light microspore. Results: Total antioxidant capacity (TAC) and glutathione (GSH) levels significantly decreased, while malondialdehyde (MDA) and total oxidant status (TOS) were significantly increased in the liver, and intestine of the NAFLD and CCl4 group compared with control rats. However, the use of nanoparticles significantly normalized these markers. The levels of the TNF-α were significantly reduced in the nanoparticle group as compared with NAFLD model and CCl4-treated rats. CeO2 NPs also normalized the liver and intestinal histological changes. Conclusions: Our finding revealed that CeO2 NPs has potential protective effects by increasing antioxidant activity, and reducing inflammation.
format	article
author	Ebrahim Abbasi Seyed Alireza Vafaei Nima Naseri Ali Darini Masoumeh Taheri Azandaryani Farhad Kian Ara Fatemeh Mirzaei
author_facet	Ebrahim Abbasi Seyed Alireza Vafaei Nima Naseri Ali Darini Masoumeh Taheri Azandaryani Farhad Kian Ara Fatemeh Mirzaei
author_sort	Ebrahim Abbasi
title	Protective effects of cerium oxide nanoparticles in non-alcoholic fatty liver disease (NAFLD) and carbon tetrachloride-induced liver damage in rats: Study on intestine and liver
title_short	Protective effects of cerium oxide nanoparticles in non-alcoholic fatty liver disease (NAFLD) and carbon tetrachloride-induced liver damage in rats: Study on intestine and liver
title_full	Protective effects of cerium oxide nanoparticles in non-alcoholic fatty liver disease (NAFLD) and carbon tetrachloride-induced liver damage in rats: Study on intestine and liver
title_fullStr	Protective effects of cerium oxide nanoparticles in non-alcoholic fatty liver disease (NAFLD) and carbon tetrachloride-induced liver damage in rats: Study on intestine and liver
title_full_unstemmed	Protective effects of cerium oxide nanoparticles in non-alcoholic fatty liver disease (NAFLD) and carbon tetrachloride-induced liver damage in rats: Study on intestine and liver
title_sort	protective effects of cerium oxide nanoparticles in non-alcoholic fatty liver disease (nafld) and carbon tetrachloride-induced liver damage in rats: study on intestine and liver
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/ab2afab59d974fb78691e52ab31c4a99
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Protective effects of cerium oxide nanoparticles in non-alcoholic fatty liver disease (NAFLD) and carbon tetrachloride-induced liver damage in rats: Study on intestine and liver

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