Advances in biomedical study of the myopia-related signaling pathways and mechanisms

Myopia has become one of the most critical health problems in the world with the increasing time spent indoors and increasing close work. Pathological myopia may have multiple complications, such as myopic macular degeneration, retinal detachment, cataracts, open-angle glaucoma, and severe cases tha...

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Autores principales:	Jing Yang, Xinli Ouyang, Hong Fu, Xinyu Hou, Yan Liu, Yongfang Xie, Haiqun Yu, Guohui Wang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Myopia Signaling pathways Dopamine Collagen TGF-β HIF-1α Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/ab2df657e4694beebb978558490a9c07
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spelling	oai:doaj.org-article:ab2df657e4694beebb978558490a9c072021-12-02T04:59:07ZAdvances in biomedical study of the myopia-related signaling pathways and mechanisms0753-332210.1016/j.biopha.2021.112472https://doaj.org/article/ab2df657e4694beebb978558490a9c072022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221012580https://doaj.org/toc/0753-3322Myopia has become one of the most critical health problems in the world with the increasing time spent indoors and increasing close work. Pathological myopia may have multiple complications, such as myopic macular degeneration, retinal detachment, cataracts, open-angle glaucoma, and severe cases that can cause blindness. Mounting evidence suggests that the cause of myopia can be attributed to the complex interaction of environmental exposure and genetic susceptibility. An increasing number of researchers have focused on the genetic pathogenesis of myopia in recent years. Scleral remodeling and excessive axial elongating induced retina thinning and even retinal detachment are myopia's most important pathological manifestations. The related signaling pathways are indispensable in myopia occurrence and development, such as dopamine, nitric oxide, TGF-β, HIF-1α, etc. We review the current major and recent progress of biomedicine on myopia-related signaling pathways and mechanisms.Jing YangXinli OuyangHong FuXinyu HouYan LiuYongfang XieHaiqun YuGuohui WangElsevierarticleMyopiaSignaling pathwaysDopamineCollagenTGF-βHIF-1αTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112472- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Myopia Signaling pathways Dopamine Collagen TGF-β HIF-1α Therapeutics. Pharmacology RM1-950
spellingShingle	Myopia Signaling pathways Dopamine Collagen TGF-β HIF-1α Therapeutics. Pharmacology RM1-950 Jing Yang Xinli Ouyang Hong Fu Xinyu Hou Yan Liu Yongfang Xie Haiqun Yu Guohui Wang Advances in biomedical study of the myopia-related signaling pathways and mechanisms
description	Myopia has become one of the most critical health problems in the world with the increasing time spent indoors and increasing close work. Pathological myopia may have multiple complications, such as myopic macular degeneration, retinal detachment, cataracts, open-angle glaucoma, and severe cases that can cause blindness. Mounting evidence suggests that the cause of myopia can be attributed to the complex interaction of environmental exposure and genetic susceptibility. An increasing number of researchers have focused on the genetic pathogenesis of myopia in recent years. Scleral remodeling and excessive axial elongating induced retina thinning and even retinal detachment are myopia's most important pathological manifestations. The related signaling pathways are indispensable in myopia occurrence and development, such as dopamine, nitric oxide, TGF-β, HIF-1α, etc. We review the current major and recent progress of biomedicine on myopia-related signaling pathways and mechanisms.
format	article
author	Jing Yang Xinli Ouyang Hong Fu Xinyu Hou Yan Liu Yongfang Xie Haiqun Yu Guohui Wang
author_facet	Jing Yang Xinli Ouyang Hong Fu Xinyu Hou Yan Liu Yongfang Xie Haiqun Yu Guohui Wang
author_sort	Jing Yang
title	Advances in biomedical study of the myopia-related signaling pathways and mechanisms
title_short	Advances in biomedical study of the myopia-related signaling pathways and mechanisms
title_full	Advances in biomedical study of the myopia-related signaling pathways and mechanisms
title_fullStr	Advances in biomedical study of the myopia-related signaling pathways and mechanisms
title_full_unstemmed	Advances in biomedical study of the myopia-related signaling pathways and mechanisms
title_sort	advances in biomedical study of the myopia-related signaling pathways and mechanisms
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/ab2df657e4694beebb978558490a9c07
work_keys_str_mv	AT jingyang advancesinbiomedicalstudyofthemyopiarelatedsignalingpathwaysandmechanisms AT xinliouyang advancesinbiomedicalstudyofthemyopiarelatedsignalingpathwaysandmechanisms AT hongfu advancesinbiomedicalstudyofthemyopiarelatedsignalingpathwaysandmechanisms AT xinyuhou advancesinbiomedicalstudyofthemyopiarelatedsignalingpathwaysandmechanisms AT yanliu advancesinbiomedicalstudyofthemyopiarelatedsignalingpathwaysandmechanisms AT yongfangxie advancesinbiomedicalstudyofthemyopiarelatedsignalingpathwaysandmechanisms AT haiqunyu advancesinbiomedicalstudyofthemyopiarelatedsignalingpathwaysandmechanisms AT guohuiwang advancesinbiomedicalstudyofthemyopiarelatedsignalingpathwaysandmechanisms
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Advances in biomedical study of the myopia-related signaling pathways and mechanisms

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