pH-sensitive doxorubicin-tocopherol succinate prodrug encapsulated in docosahexaenoic acid-based nanostructured lipid carriers: An effective strategy to improve pharmacokinetics and reduce toxic effects

pH-sensitive doxorubicin-tocopherol succinate prodrug encapsulated in docosahexaenoic acid-based nanostructured lipid carriers: An effective strategy to improve pharmacokinetics and reduce toxic effects

Side effects often limit the use of doxorubicin (DOX) in cancer treatment. We have recently developed a nanostructured lipid carrier (NLC) formulation for synergistic chemotherapy, encapsulating DOX and the anticancer adjuvants docosahexaenoic acid (DHA) and α-tocopherol succinate (TS). Hydrophobic...

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Autores principales: Eduardo Burgarelli Lages, Renata Salgado Fernandes, Marina Mol Sena Andrade, Nitchawat Paiyabhroma, Renata Barbosa de Oliveira, Christian Fernandes, Geovanni Dantas Cassali, Pierre Sicard, Sylvain Richard, André Luís Branco de Barros, Lucas Antônio Miranda Ferreira
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
Materias:
Doxorubicin
Nanomedicine
Ion-pairing
Amide
Hydrazone
Antitumor activity
Therapeutics. Pharmacology
RM1-950
Acceso en línea:https://doaj.org/article/ab30badd949049e1a663721747a3b7e3
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