Hemin as a novel candidate for treating COVID-19 via heme oxygenase-1 induction

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the coronavirus disease-19 (COVID-19). More than 143 million cases of COVID-19 have been reported to date, with the global death rate at 2.13%. Currently, there are no licensed therapeutics for controllin...

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Autores principales:	Dong-Hwi Kim, Hee-Seop Ahn, Hyeon-Jeong Go, Da-Yoon Kim, Jae-Hyeong Kim, Joong-Bok Lee, Seung-Yong Park, Chang-Seon Song, Sang-Won Lee, Sang-Do Ha, Changsun Choi, In-Soo Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ab312a20c539464aad22146e550b1c78
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spelling	oai:doaj.org-article:ab312a20c539464aad22146e550b1c782021-11-08T10:55:42ZHemin as a novel candidate for treating COVID-19 via heme oxygenase-1 induction10.1038/s41598-021-01054-32045-2322https://doaj.org/article/ab312a20c539464aad22146e550b1c782021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01054-3https://doaj.org/toc/2045-2322Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the coronavirus disease-19 (COVID-19). More than 143 million cases of COVID-19 have been reported to date, with the global death rate at 2.13%. Currently, there are no licensed therapeutics for controlling SARS-CoV-2 infection. The antiviral effects of heme oxygenase-1 (HO-1), a cytoprotective enzyme that inhibits the inflammatory response and reduces oxidative stress, have been investigated in several viral infections. To confirm whether HO-1 suppresses SARS-CoV-2 infection, we assessed the antiviral activity of hemin, an effective and safe HO-1 inducer, in SARS-CoV-2 infection. We found that treatment with hemin efficiently suppressed SARS-CoV-2 replication (selectivity index: 249.7012). Besides, the transient expression of HO-1 using an expression vector also suppressed the growth of the virus in cells. Free iron and biliverdin, which are metabolic byproducts of heme catalysis by HO-1, also suppressed the viral infection. Additionally, hemin indirectly increased the expression of interferon-stimulated proteins known to restrict SARS-CoV-2 replication. Overall, the findings suggested that HO-1, induced by hemin, effectively suppressed SARS-CoV-2 in vitro. Therefore, HO-1 could be potential therapeutic candidate for COVID-19.Dong-Hwi KimHee-Seop AhnHyeon-Jeong GoDa-Yoon KimJae-Hyeong KimJoong-Bok LeeSeung-Yong ParkChang-Seon SongSang-Won LeeSang-Do HaChangsun ChoiIn-Soo ChoiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dong-Hwi Kim Hee-Seop Ahn Hyeon-Jeong Go Da-Yoon Kim Jae-Hyeong Kim Joong-Bok Lee Seung-Yong Park Chang-Seon Song Sang-Won Lee Sang-Do Ha Changsun Choi In-Soo Choi Hemin as a novel candidate for treating COVID-19 via heme oxygenase-1 induction
description	Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the coronavirus disease-19 (COVID-19). More than 143 million cases of COVID-19 have been reported to date, with the global death rate at 2.13%. Currently, there are no licensed therapeutics for controlling SARS-CoV-2 infection. The antiviral effects of heme oxygenase-1 (HO-1), a cytoprotective enzyme that inhibits the inflammatory response and reduces oxidative stress, have been investigated in several viral infections. To confirm whether HO-1 suppresses SARS-CoV-2 infection, we assessed the antiviral activity of hemin, an effective and safe HO-1 inducer, in SARS-CoV-2 infection. We found that treatment with hemin efficiently suppressed SARS-CoV-2 replication (selectivity index: 249.7012). Besides, the transient expression of HO-1 using an expression vector also suppressed the growth of the virus in cells. Free iron and biliverdin, which are metabolic byproducts of heme catalysis by HO-1, also suppressed the viral infection. Additionally, hemin indirectly increased the expression of interferon-stimulated proteins known to restrict SARS-CoV-2 replication. Overall, the findings suggested that HO-1, induced by hemin, effectively suppressed SARS-CoV-2 in vitro. Therefore, HO-1 could be potential therapeutic candidate for COVID-19.
format	article
author	Dong-Hwi Kim Hee-Seop Ahn Hyeon-Jeong Go Da-Yoon Kim Jae-Hyeong Kim Joong-Bok Lee Seung-Yong Park Chang-Seon Song Sang-Won Lee Sang-Do Ha Changsun Choi In-Soo Choi
author_facet	Dong-Hwi Kim Hee-Seop Ahn Hyeon-Jeong Go Da-Yoon Kim Jae-Hyeong Kim Joong-Bok Lee Seung-Yong Park Chang-Seon Song Sang-Won Lee Sang-Do Ha Changsun Choi In-Soo Choi
author_sort	Dong-Hwi Kim
title	Hemin as a novel candidate for treating COVID-19 via heme oxygenase-1 induction
title_short	Hemin as a novel candidate for treating COVID-19 via heme oxygenase-1 induction
title_full	Hemin as a novel candidate for treating COVID-19 via heme oxygenase-1 induction
title_fullStr	Hemin as a novel candidate for treating COVID-19 via heme oxygenase-1 induction
title_full_unstemmed	Hemin as a novel candidate for treating COVID-19 via heme oxygenase-1 induction
title_sort	hemin as a novel candidate for treating covid-19 via heme oxygenase-1 induction
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ab312a20c539464aad22146e550b1c78
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Hemin as a novel candidate for treating COVID-19 via heme oxygenase-1 induction

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