Calreticulin and integrin alpha dissociation induces anti-inflammatory programming in animal models of inflammatory bowel disease
Inflammatory bowel disease (IBD) is initiated by integrins-mediated leukocyte adhesion to the activated colonic microvascular endothelium. Here, the authors show that inhibition of the calreticulin binding to integrin α subunits ameliorates the severity of IBD in animal models.
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Nature Portfolio
2018
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oai:doaj.org-article:ab36e151b5164ae2950d771f04fd04962021-12-02T17:31:13ZCalreticulin and integrin alpha dissociation induces anti-inflammatory programming in animal models of inflammatory bowel disease10.1038/s41467-018-04420-42041-1723https://doaj.org/article/ab36e151b5164ae2950d771f04fd04962018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04420-4https://doaj.org/toc/2041-1723Inflammatory bowel disease (IBD) is initiated by integrins-mediated leukocyte adhesion to the activated colonic microvascular endothelium. Here, the authors show that inhibition of the calreticulin binding to integrin α subunits ameliorates the severity of IBD in animal models.Masayoshi OhkuroJun-Dal KimYoshikazu KuboiYuki HayashiHayase MizukamiHiroko Kobayashi-KuramochiKenzo MuramotoManabu ShiratoFumiko Michikawa-TanakaJun MoriyaTeruya KozakiKazuma TakaseKenichi ChibaKishan Lal AgarwalaTakayuki KimuraMakoto KotakeTetsuya KawaharaNaoki YonedaShinsuke HirotaHiroshi AzumaNobuko Ozasa-KomuraYoshiaki OhashiMasafumi MurataniKeiji KimuraIeharu HishinumaAkiyoshi FukamizuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018) |
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| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
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Science Q Masayoshi Ohkuro Jun-Dal Kim Yoshikazu Kuboi Yuki Hayashi Hayase Mizukami Hiroko Kobayashi-Kuramochi Kenzo Muramoto Manabu Shirato Fumiko Michikawa-Tanaka Jun Moriya Teruya Kozaki Kazuma Takase Kenichi Chiba Kishan Lal Agarwala Takayuki Kimura Makoto Kotake Tetsuya Kawahara Naoki Yoneda Shinsuke Hirota Hiroshi Azuma Nobuko Ozasa-Komura Yoshiaki Ohashi Masafumi Muratani Keiji Kimura Ieharu Hishinuma Akiyoshi Fukamizu Calreticulin and integrin alpha dissociation induces anti-inflammatory programming in animal models of inflammatory bowel disease |
| description |
Inflammatory bowel disease (IBD) is initiated by integrins-mediated leukocyte adhesion to the activated colonic microvascular endothelium. Here, the authors show that inhibition of the calreticulin binding to integrin α subunits ameliorates the severity of IBD in animal models. |
| format |
article |
| author |
Masayoshi Ohkuro Jun-Dal Kim Yoshikazu Kuboi Yuki Hayashi Hayase Mizukami Hiroko Kobayashi-Kuramochi Kenzo Muramoto Manabu Shirato Fumiko Michikawa-Tanaka Jun Moriya Teruya Kozaki Kazuma Takase Kenichi Chiba Kishan Lal Agarwala Takayuki Kimura Makoto Kotake Tetsuya Kawahara Naoki Yoneda Shinsuke Hirota Hiroshi Azuma Nobuko Ozasa-Komura Yoshiaki Ohashi Masafumi Muratani Keiji Kimura Ieharu Hishinuma Akiyoshi Fukamizu |
| author_facet |
Masayoshi Ohkuro Jun-Dal Kim Yoshikazu Kuboi Yuki Hayashi Hayase Mizukami Hiroko Kobayashi-Kuramochi Kenzo Muramoto Manabu Shirato Fumiko Michikawa-Tanaka Jun Moriya Teruya Kozaki Kazuma Takase Kenichi Chiba Kishan Lal Agarwala Takayuki Kimura Makoto Kotake Tetsuya Kawahara Naoki Yoneda Shinsuke Hirota Hiroshi Azuma Nobuko Ozasa-Komura Yoshiaki Ohashi Masafumi Muratani Keiji Kimura Ieharu Hishinuma Akiyoshi Fukamizu |
| author_sort |
Masayoshi Ohkuro |
| title |
Calreticulin and integrin alpha dissociation induces anti-inflammatory programming in animal models of inflammatory bowel disease |
| title_short |
Calreticulin and integrin alpha dissociation induces anti-inflammatory programming in animal models of inflammatory bowel disease |
| title_full |
Calreticulin and integrin alpha dissociation induces anti-inflammatory programming in animal models of inflammatory bowel disease |
| title_fullStr |
Calreticulin and integrin alpha dissociation induces anti-inflammatory programming in animal models of inflammatory bowel disease |
| title_full_unstemmed |
Calreticulin and integrin alpha dissociation induces anti-inflammatory programming in animal models of inflammatory bowel disease |
| title_sort |
calreticulin and integrin alpha dissociation induces anti-inflammatory programming in animal models of inflammatory bowel disease |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/ab36e151b5164ae2950d771f04fd0496 |
| work_keys_str_mv |
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