Incidence, predictors, and outcomes of DAPT non-compliance in planned vs. ad hoc PCI in chronic coronary syndrome.

<h4>Objective</h4>The disruption of dual antiplatelet therapy (DAPT) causes more adverse events after percutaneous coronary intervention (PCI). However, incidence and predictors of DAPT non-compliance are unknown in chronic coronary syndrome patients when compared between planned and ad...

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Auteurs principaux:	Jahanzeb Malik, Husnain Yousaf, Waleed Abbasi, Nouman Hameed, Muhammad Mohsin, Abdul Wahab Shahid, Mahnoor Fatima
Format:	article
Langue:	EN
Publié:	Public Library of Science (PLoS) 2021
Sujets:	Medicine R Science Q
Accès en ligne:	https://doaj.org/article/ab378f26aa694694b11616a366f0cc7b
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spelling	oai:doaj.org-article:ab378f26aa694694b11616a366f0cc7b2021-12-02T20:06:54ZIncidence, predictors, and outcomes of DAPT non-compliance in planned vs. ad hoc PCI in chronic coronary syndrome.1932-620310.1371/journal.pone.0254941https://doaj.org/article/ab378f26aa694694b11616a366f0cc7b2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254941https://doaj.org/toc/1932-6203<h4>Objective</h4>The disruption of dual antiplatelet therapy (DAPT) causes more adverse events after percutaneous coronary intervention (PCI). However, incidence and predictors of DAPT non-compliance are unknown in chronic coronary syndrome patients when compared between planned and ad hoc PCI.<h4>Methods</h4>This investigation was aimed to assess the incidence, predictors, outcomes, and primary mode of non-compliance of DAPT in patients with chronic coronary syndrome undergoing their first PCI. We analyzed the patients between planned (group 1) and ad hoc (group 2) PCI.<h4>Results</h4>There were a total of 628 participants in this investigation (370 were in planned PCI and 270 in the ad hoc PCI group). Out of 628 patients, by one month, 10% left DAPT in planned PCI group and 19.7% in ad hoc PCI group (aOR: 0.451, 95% CI: 0.285-0.713, p = 0.001). At 12 months, DAPT non-compliance was significantly more in ad hoc PCI group (52.7% vs. 47.8%; aOR: 0.647 95% CI: 0.470-0.891, p = 0.008). Age > 65 years (p < 0.001), low education status (p = 0.012), residents of rural areas (p < 0.001), ad hoc PCI group (p = 0.036), and angina class II (p = 0.038) were predictors for DAPT non-compliance in this cohort.<h4>Conclusion</h4>Approximately 5 out of 10 patients disrupt DAPT due to non-compliance. This investigation provides an insight on additional predictors of non-compliance to DAPT, helping us to identify and address specific patient-related factors for disruption.Jahanzeb MalikHusnain YousafWaleed AbbasiNouman HameedMuhammad MohsinAbdul Wahab ShahidMahnoor FatimaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254941 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jahanzeb Malik Husnain Yousaf Waleed Abbasi Nouman Hameed Muhammad Mohsin Abdul Wahab Shahid Mahnoor Fatima Incidence, predictors, and outcomes of DAPT non-compliance in planned vs. ad hoc PCI in chronic coronary syndrome.
description	<h4>Objective</h4>The disruption of dual antiplatelet therapy (DAPT) causes more adverse events after percutaneous coronary intervention (PCI). However, incidence and predictors of DAPT non-compliance are unknown in chronic coronary syndrome patients when compared between planned and ad hoc PCI.<h4>Methods</h4>This investigation was aimed to assess the incidence, predictors, outcomes, and primary mode of non-compliance of DAPT in patients with chronic coronary syndrome undergoing their first PCI. We analyzed the patients between planned (group 1) and ad hoc (group 2) PCI.<h4>Results</h4>There were a total of 628 participants in this investigation (370 were in planned PCI and 270 in the ad hoc PCI group). Out of 628 patients, by one month, 10% left DAPT in planned PCI group and 19.7% in ad hoc PCI group (aOR: 0.451, 95% CI: 0.285-0.713, p = 0.001). At 12 months, DAPT non-compliance was significantly more in ad hoc PCI group (52.7% vs. 47.8%; aOR: 0.647 95% CI: 0.470-0.891, p = 0.008). Age > 65 years (p < 0.001), low education status (p = 0.012), residents of rural areas (p < 0.001), ad hoc PCI group (p = 0.036), and angina class II (p = 0.038) were predictors for DAPT non-compliance in this cohort.<h4>Conclusion</h4>Approximately 5 out of 10 patients disrupt DAPT due to non-compliance. This investigation provides an insight on additional predictors of non-compliance to DAPT, helping us to identify and address specific patient-related factors for disruption.
format	article
author	Jahanzeb Malik Husnain Yousaf Waleed Abbasi Nouman Hameed Muhammad Mohsin Abdul Wahab Shahid Mahnoor Fatima
author_facet	Jahanzeb Malik Husnain Yousaf Waleed Abbasi Nouman Hameed Muhammad Mohsin Abdul Wahab Shahid Mahnoor Fatima
author_sort	Jahanzeb Malik
title	Incidence, predictors, and outcomes of DAPT non-compliance in planned vs. ad hoc PCI in chronic coronary syndrome.
title_short	Incidence, predictors, and outcomes of DAPT non-compliance in planned vs. ad hoc PCI in chronic coronary syndrome.
title_full	Incidence, predictors, and outcomes of DAPT non-compliance in planned vs. ad hoc PCI in chronic coronary syndrome.
title_fullStr	Incidence, predictors, and outcomes of DAPT non-compliance in planned vs. ad hoc PCI in chronic coronary syndrome.
title_full_unstemmed	Incidence, predictors, and outcomes of DAPT non-compliance in planned vs. ad hoc PCI in chronic coronary syndrome.
title_sort	incidence, predictors, and outcomes of dapt non-compliance in planned vs. ad hoc pci in chronic coronary syndrome.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/ab378f26aa694694b11616a366f0cc7b
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Incidence, predictors, and outcomes of DAPT non-compliance in planned vs. ad hoc PCI in chronic coronary syndrome.

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