Expression of long non-coding RNA MFI2-AS1 is a strong predictor of recurrence in sporadic localized clear-cell renal cell carcinoma

Abstract Prediction of recurrence is a challenge for the development of adjuvant treatments in clear-cell renal cell carcinoma (ccRCC). In these tumors, expression of long non-coding RNAs (lncRNAs) are deregulated and closely associated with prognosis. Thus, we aimed to predict ccRCC recurrence risk...

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Autores principales:	Ronan Flippot, Roger Mouawad, Jean-Philippe Spano, Morgan Rouprêt, Eva Compérat, Marc-Olivier Bitker, Jérôme Parra, Christophe Vaessen, Frederick Allanic, Quentin Manach, Nizar M. Tannir, David Khayat, Xiaoping Su, Gabriel G. Malouf
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ab3db300ab44444faa8eb16df86fe13e
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spelling	oai:doaj.org-article:ab3db300ab44444faa8eb16df86fe13e2021-12-02T16:07:00ZExpression of long non-coding RNA MFI2-AS1 is a strong predictor of recurrence in sporadic localized clear-cell renal cell carcinoma10.1038/s41598-017-08363-62045-2322https://doaj.org/article/ab3db300ab44444faa8eb16df86fe13e2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08363-6https://doaj.org/toc/2045-2322Abstract Prediction of recurrence is a challenge for the development of adjuvant treatments in clear-cell renal cell carcinoma (ccRCC). In these tumors, expression of long non-coding RNAs (lncRNAs) are deregulated and closely associated with prognosis. Thus, we aimed to predict ccRCC recurrence risk using lncRNA expression. We identified prognostic lncRNAs in a training set of 351 localized ccRCCs from The Cancer Genome Atlas and validated lncRNA-based recurrence classification in an independent cohort of 167 localized ccRCCs. We identified lncRNA MFI2-AS1 as best candidate in the training set. In the validation cohort, MFI2-AS1 expression was independently associated with shorter disease-free survival (Hazard Ratio (HR) for relapse 3.5, p = 0.0001). Combined with Leibovich classification, MFI2-AS1 status improved prediction of recurrence (C-index 0.70) compared to MFI2-AS1 alone (0.67) and Leibovich classification alone (0.66). In patients with aggressive tumors (Leibovich ≥5), MFI2-AS1 expression was associated with dramatically increased risk of relapse (HR 12.16, p < 0.0001) compared to patients with undetectable MFI2-AS1 who had favorable outcomes. Compared to normal samples, MFI2-AS1 was upregulated in tumor tissue, and higher expression was associated with metastatic dissemination. Overall, MFI2-AS1 status improves patient stratification in localized ccRCC, which supports further integration of lncRNAs in molecular cancer classifications.Ronan FlippotRoger MouawadJean-Philippe SpanoMorgan RouprêtEva CompératMarc-Olivier BitkerJérôme ParraChristophe VaessenFrederick AllanicQuentin ManachNizar M. TannirDavid KhayatXiaoping SuGabriel G. MaloufNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ronan Flippot Roger Mouawad Jean-Philippe Spano Morgan Rouprêt Eva Compérat Marc-Olivier Bitker Jérôme Parra Christophe Vaessen Frederick Allanic Quentin Manach Nizar M. Tannir David Khayat Xiaoping Su Gabriel G. Malouf Expression of long non-coding RNA MFI2-AS1 is a strong predictor of recurrence in sporadic localized clear-cell renal cell carcinoma
description	Abstract Prediction of recurrence is a challenge for the development of adjuvant treatments in clear-cell renal cell carcinoma (ccRCC). In these tumors, expression of long non-coding RNAs (lncRNAs) are deregulated and closely associated with prognosis. Thus, we aimed to predict ccRCC recurrence risk using lncRNA expression. We identified prognostic lncRNAs in a training set of 351 localized ccRCCs from The Cancer Genome Atlas and validated lncRNA-based recurrence classification in an independent cohort of 167 localized ccRCCs. We identified lncRNA MFI2-AS1 as best candidate in the training set. In the validation cohort, MFI2-AS1 expression was independently associated with shorter disease-free survival (Hazard Ratio (HR) for relapse 3.5, p = 0.0001). Combined with Leibovich classification, MFI2-AS1 status improved prediction of recurrence (C-index 0.70) compared to MFI2-AS1 alone (0.67) and Leibovich classification alone (0.66). In patients with aggressive tumors (Leibovich ≥5), MFI2-AS1 expression was associated with dramatically increased risk of relapse (HR 12.16, p < 0.0001) compared to patients with undetectable MFI2-AS1 who had favorable outcomes. Compared to normal samples, MFI2-AS1 was upregulated in tumor tissue, and higher expression was associated with metastatic dissemination. Overall, MFI2-AS1 status improves patient stratification in localized ccRCC, which supports further integration of lncRNAs in molecular cancer classifications.
format	article
author	Ronan Flippot Roger Mouawad Jean-Philippe Spano Morgan Rouprêt Eva Compérat Marc-Olivier Bitker Jérôme Parra Christophe Vaessen Frederick Allanic Quentin Manach Nizar M. Tannir David Khayat Xiaoping Su Gabriel G. Malouf
author_facet	Ronan Flippot Roger Mouawad Jean-Philippe Spano Morgan Rouprêt Eva Compérat Marc-Olivier Bitker Jérôme Parra Christophe Vaessen Frederick Allanic Quentin Manach Nizar M. Tannir David Khayat Xiaoping Su Gabriel G. Malouf
author_sort	Ronan Flippot
title	Expression of long non-coding RNA MFI2-AS1 is a strong predictor of recurrence in sporadic localized clear-cell renal cell carcinoma
title_short	Expression of long non-coding RNA MFI2-AS1 is a strong predictor of recurrence in sporadic localized clear-cell renal cell carcinoma
title_full	Expression of long non-coding RNA MFI2-AS1 is a strong predictor of recurrence in sporadic localized clear-cell renal cell carcinoma
title_fullStr	Expression of long non-coding RNA MFI2-AS1 is a strong predictor of recurrence in sporadic localized clear-cell renal cell carcinoma
title_full_unstemmed	Expression of long non-coding RNA MFI2-AS1 is a strong predictor of recurrence in sporadic localized clear-cell renal cell carcinoma
title_sort	expression of long non-coding rna mfi2-as1 is a strong predictor of recurrence in sporadic localized clear-cell renal cell carcinoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ab3db300ab44444faa8eb16df86fe13e
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Expression of long non-coding RNA MFI2-AS1 is a strong predictor of recurrence in sporadic localized clear-cell renal cell carcinoma

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