Replication of annulus fibrosus through fabrication and characterization of polyurethane and cellulose nanocrystal composite scaffolds

This study sought to obtain a simple scaffold for annulus fibrosus (AF) repair or replacement using a combination of polyurethane (PU) reinforced with cellulose nanocrystals (CNCs). Composites containing up to 20 wt% CNCs were solvent casted and fabricated into ribbons and radially layered structure...

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Autores principales:	Brody A. Frost, E. Johan Foster
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2019
Materias:	Intervertebral disc degeneration annulus fibrosus scaffolds thermoplastic polyurethane cellulose nanocrystals tunable polyurethane nanocomposites solvent casting radially layered composite structures mechanical properties characterization Materials of engineering and construction. Mechanics of materials TA401-492 Polymers and polymer manufacture TP1080-1185
Acceso en línea:	https://doaj.org/article/ab427aa219d949bba95cad71e970bcfb
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spelling	oai:doaj.org-article:ab427aa219d949bba95cad71e970bcfb2021-12-02T04:17:52ZReplication of annulus fibrosus through fabrication and characterization of polyurethane and cellulose nanocrystal composite scaffolds2055-03242055-033210.1080/20550324.2019.1585651https://doaj.org/article/ab427aa219d949bba95cad71e970bcfb2019-03-01T00:00:00Zhttp://dx.doi.org/10.1080/20550324.2019.1585651https://doaj.org/toc/2055-0324https://doaj.org/toc/2055-0332This study sought to obtain a simple scaffold for annulus fibrosus (AF) repair or replacement using a combination of polyurethane (PU) reinforced with cellulose nanocrystals (CNCs). Composites containing up to 20 wt% CNCs were solvent casted and fabricated into ribbons and radially layered structures to be mechanically tested in tension, compression, creep, and relaxation. Tension and compression testing on swollen composite films and ringed structures, respectively, revealed that the PU 90/10 and PU 80/20 composites had elastic moduli most closely related to the natural AF tissues. Creep and relaxation revealed that the composite materials show a greater percentage of elastic response and longer relaxation times than natural intervertebral disc (IVD) tissues. It was shown that this approach leads to a scaffold that nearly mimics the mechanical properties of natural IVD tissues, while allowing fine tuning of these mechanical properties by varying CNC content and the ringed structure.Brody A. FrostE. Johan FosterTaylor & Francis GrouparticleIntervertebral disc degenerationannulus fibrosus scaffoldsthermoplastic polyurethanecellulose nanocrystalstunable polyurethane nanocompositessolvent castingradially layered composite structuresmechanical properties characterizationMaterials of engineering and construction. Mechanics of materialsTA401-492Polymers and polymer manufactureTP1080-1185ENNanocomposites, Vol 0, Iss 0, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Intervertebral disc degeneration annulus fibrosus scaffolds thermoplastic polyurethane cellulose nanocrystals tunable polyurethane nanocomposites solvent casting radially layered composite structures mechanical properties characterization Materials of engineering and construction. Mechanics of materials TA401-492 Polymers and polymer manufacture TP1080-1185
spellingShingle	Intervertebral disc degeneration annulus fibrosus scaffolds thermoplastic polyurethane cellulose nanocrystals tunable polyurethane nanocomposites solvent casting radially layered composite structures mechanical properties characterization Materials of engineering and construction. Mechanics of materials TA401-492 Polymers and polymer manufacture TP1080-1185 Brody A. Frost E. Johan Foster Replication of annulus fibrosus through fabrication and characterization of polyurethane and cellulose nanocrystal composite scaffolds
description	This study sought to obtain a simple scaffold for annulus fibrosus (AF) repair or replacement using a combination of polyurethane (PU) reinforced with cellulose nanocrystals (CNCs). Composites containing up to 20 wt% CNCs were solvent casted and fabricated into ribbons and radially layered structures to be mechanically tested in tension, compression, creep, and relaxation. Tension and compression testing on swollen composite films and ringed structures, respectively, revealed that the PU 90/10 and PU 80/20 composites had elastic moduli most closely related to the natural AF tissues. Creep and relaxation revealed that the composite materials show a greater percentage of elastic response and longer relaxation times than natural intervertebral disc (IVD) tissues. It was shown that this approach leads to a scaffold that nearly mimics the mechanical properties of natural IVD tissues, while allowing fine tuning of these mechanical properties by varying CNC content and the ringed structure.
format	article
author	Brody A. Frost E. Johan Foster
author_facet	Brody A. Frost E. Johan Foster
author_sort	Brody A. Frost
title	Replication of annulus fibrosus through fabrication and characterization of polyurethane and cellulose nanocrystal composite scaffolds
title_short	Replication of annulus fibrosus through fabrication and characterization of polyurethane and cellulose nanocrystal composite scaffolds
title_full	Replication of annulus fibrosus through fabrication and characterization of polyurethane and cellulose nanocrystal composite scaffolds
title_fullStr	Replication of annulus fibrosus through fabrication and characterization of polyurethane and cellulose nanocrystal composite scaffolds
title_full_unstemmed	Replication of annulus fibrosus through fabrication and characterization of polyurethane and cellulose nanocrystal composite scaffolds
title_sort	replication of annulus fibrosus through fabrication and characterization of polyurethane and cellulose nanocrystal composite scaffolds
publisher	Taylor & Francis Group
publishDate	2019
url	https://doaj.org/article/ab427aa219d949bba95cad71e970bcfb
work_keys_str_mv	AT brodyafrost replicationofannulusfibrosusthroughfabricationandcharacterizationofpolyurethaneandcellulosenanocrystalcompositescaffolds AT ejohanfoster replicationofannulusfibrosusthroughfabricationandcharacterizationofpolyurethaneandcellulosenanocrystalcompositescaffolds
_version_	1718401326859157504

Replication of annulus fibrosus through fabrication and characterization of polyurethane and cellulose nanocrystal composite scaffolds

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