Clonal evolution patterns in acute myeloid leukemia with NPM1 mutation
NPM1 gene mutation is a founding event in acute myeloid leukaemia. Here, the authors find that at relapse, some patients lose the NPM1 mutation and show distinct mutational and gene expression patterns, highlighting a potential route for relapse.
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Nature Portfolio
2019
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oai:doaj.org-article:ab42b55dd8f0489199905265493911712021-12-02T14:40:17ZClonal evolution patterns in acute myeloid leukemia with NPM1 mutation10.1038/s41467-019-09745-22041-1723https://doaj.org/article/ab42b55dd8f0489199905265493911712019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09745-2https://doaj.org/toc/2041-1723NPM1 gene mutation is a founding event in acute myeloid leukaemia. Here, the authors find that at relapse, some patients lose the NPM1 mutation and show distinct mutational and gene expression patterns, highlighting a potential route for relapse.Sibylle CocciardiAnna DolnikSilke Kapp-SchwoererFrank G. RückerSusanne LuxTamara J. BlätteSabrina SkambraksJan KrönkeFlorian H. HeidelTina M. SchnöderAndrea CorbaciogluVerena I. GaidzikPeter PaschkaVeronica TeleanuGudrun GöhringFelicitas TholMichael HeuserArnold GanserDaniela WeberEric SträngHans A. KestlerHartmut DöhnerLars BullingerKonstanze DöhnerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Sibylle Cocciardi Anna Dolnik Silke Kapp-Schwoerer Frank G. Rücker Susanne Lux Tamara J. Blätte Sabrina Skambraks Jan Krönke Florian H. Heidel Tina M. Schnöder Andrea Corbacioglu Verena I. Gaidzik Peter Paschka Veronica Teleanu Gudrun Göhring Felicitas Thol Michael Heuser Arnold Ganser Daniela Weber Eric Sträng Hans A. Kestler Hartmut Döhner Lars Bullinger Konstanze Döhner Clonal evolution patterns in acute myeloid leukemia with NPM1 mutation |
| description |
NPM1 gene mutation is a founding event in acute myeloid leukaemia. Here, the authors find that at relapse, some patients lose the NPM1 mutation and show distinct mutational and gene expression patterns, highlighting a potential route for relapse. |
| format |
article |
| author |
Sibylle Cocciardi Anna Dolnik Silke Kapp-Schwoerer Frank G. Rücker Susanne Lux Tamara J. Blätte Sabrina Skambraks Jan Krönke Florian H. Heidel Tina M. Schnöder Andrea Corbacioglu Verena I. Gaidzik Peter Paschka Veronica Teleanu Gudrun Göhring Felicitas Thol Michael Heuser Arnold Ganser Daniela Weber Eric Sträng Hans A. Kestler Hartmut Döhner Lars Bullinger Konstanze Döhner |
| author_facet |
Sibylle Cocciardi Anna Dolnik Silke Kapp-Schwoerer Frank G. Rücker Susanne Lux Tamara J. Blätte Sabrina Skambraks Jan Krönke Florian H. Heidel Tina M. Schnöder Andrea Corbacioglu Verena I. Gaidzik Peter Paschka Veronica Teleanu Gudrun Göhring Felicitas Thol Michael Heuser Arnold Ganser Daniela Weber Eric Sträng Hans A. Kestler Hartmut Döhner Lars Bullinger Konstanze Döhner |
| author_sort |
Sibylle Cocciardi |
| title |
Clonal evolution patterns in acute myeloid leukemia with NPM1 mutation |
| title_short |
Clonal evolution patterns in acute myeloid leukemia with NPM1 mutation |
| title_full |
Clonal evolution patterns in acute myeloid leukemia with NPM1 mutation |
| title_fullStr |
Clonal evolution patterns in acute myeloid leukemia with NPM1 mutation |
| title_full_unstemmed |
Clonal evolution patterns in acute myeloid leukemia with NPM1 mutation |
| title_sort |
clonal evolution patterns in acute myeloid leukemia with npm1 mutation |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/ab42b55dd8f048919990526549391171 |
| work_keys_str_mv |
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