The Risk of Malignancies in Celiac Disease—A Literature Review

Celiac disease (CeD) is an immune-mediated enteropathy precipitated by ingestion of gluten in genetically predisposed individuals. Considering that CeD affects approximately 1% of the Western population, it may be considered a global health problem. In the large majority of cases, CeD has a benign c...

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Autores principales:	Filippo Pelizzaro, Ilaria Marsilio, Matteo Fassan, Francesco Piazza, Brigida Barberio, Anna D’Odorico, Edoardo V. Savarino, Fabio Farinati, Fabiana Zingone
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	celiac disease malignancy complication tumor lymphoma carcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/ab442dac6e3e4f708276d49ca549a008
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spelling	oai:doaj.org-article:ab442dac6e3e4f708276d49ca549a0082021-11-11T15:27:13ZThe Risk of Malignancies in Celiac Disease—A Literature Review10.3390/cancers132152882072-6694https://doaj.org/article/ab442dac6e3e4f708276d49ca549a0082021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5288https://doaj.org/toc/2072-6694Celiac disease (CeD) is an immune-mediated enteropathy precipitated by ingestion of gluten in genetically predisposed individuals. Considering that CeD affects approximately 1% of the Western population, it may be considered a global health problem. In the large majority of cases, CeD has a benign course, characterized by the complete resolution of symptoms and a normal life expectancy after the beginning of a gluten-free-diet (GFD); however, an increased risk of developing malignancies, such as lymphomas and small bowel carcinoma (SBC), has been reported. In particular, enteropathy-associated T-cell lymphoma (EATL), a peculiar type of T-cell lymphoma, is characteristically associated with CeD. Moreover, the possible association between CeD and several other malignancies has been also investigated in a considerable number of studies. In this paper, we aim to provide a comprehensive review of the current knowledge about the associations between CeD and cancer, focusing in particular on EATL and SBC, two rare but aggressive malignancies.Filippo PelizzaroIlaria MarsilioMatteo FassanFrancesco PiazzaBrigida BarberioAnna D’OdoricoEdoardo V. SavarinoFabio FarinatiFabiana ZingoneMDPI AGarticleceliac diseasemalignancycomplicationtumorlymphomacarcinomaNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5288, p 5288 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	celiac disease malignancy complication tumor lymphoma carcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	celiac disease malignancy complication tumor lymphoma carcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Filippo Pelizzaro Ilaria Marsilio Matteo Fassan Francesco Piazza Brigida Barberio Anna D’Odorico Edoardo V. Savarino Fabio Farinati Fabiana Zingone The Risk of Malignancies in Celiac Disease—A Literature Review
description	Celiac disease (CeD) is an immune-mediated enteropathy precipitated by ingestion of gluten in genetically predisposed individuals. Considering that CeD affects approximately 1% of the Western population, it may be considered a global health problem. In the large majority of cases, CeD has a benign course, characterized by the complete resolution of symptoms and a normal life expectancy after the beginning of a gluten-free-diet (GFD); however, an increased risk of developing malignancies, such as lymphomas and small bowel carcinoma (SBC), has been reported. In particular, enteropathy-associated T-cell lymphoma (EATL), a peculiar type of T-cell lymphoma, is characteristically associated with CeD. Moreover, the possible association between CeD and several other malignancies has been also investigated in a considerable number of studies. In this paper, we aim to provide a comprehensive review of the current knowledge about the associations between CeD and cancer, focusing in particular on EATL and SBC, two rare but aggressive malignancies.
format	article
author	Filippo Pelizzaro Ilaria Marsilio Matteo Fassan Francesco Piazza Brigida Barberio Anna D’Odorico Edoardo V. Savarino Fabio Farinati Fabiana Zingone
author_facet	Filippo Pelizzaro Ilaria Marsilio Matteo Fassan Francesco Piazza Brigida Barberio Anna D’Odorico Edoardo V. Savarino Fabio Farinati Fabiana Zingone
author_sort	Filippo Pelizzaro
title	The Risk of Malignancies in Celiac Disease—A Literature Review
title_short	The Risk of Malignancies in Celiac Disease—A Literature Review
title_full	The Risk of Malignancies in Celiac Disease—A Literature Review
title_fullStr	The Risk of Malignancies in Celiac Disease—A Literature Review
title_full_unstemmed	The Risk of Malignancies in Celiac Disease—A Literature Review
title_sort	risk of malignancies in celiac disease—a literature review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ab442dac6e3e4f708276d49ca549a008
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The Risk of Malignancies in Celiac Disease—A Literature Review

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