Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones

Insulin-like polypeptide binding proteins (IBPs) from insects can bind diverse insulin-like proteins (ILPs) including human insulin and IGFs. Here, the authors present structures of a Drosophila IBP in its free and ILP-bound forms, providing insights into the regulation of ILP bioavailability by ins...

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Autores principales:	Nikolaj Kulahin Roed, Cristina M. Viola, Ole Kristensen, Gerd Schluckebier, Mathias Norrman, Waseem Sajid, John D. Wade, Asser Sloth Andersen, Claus Kristensen, Timothy R. Ganderton, Johan P. Turkenburg, Pierre De Meyts, Andrzej M. Brzozowski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ab49da7df68b46db823e2dfac264e41c
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spelling	oai:doaj.org-article:ab49da7df68b46db823e2dfac264e41c2021-12-02T14:40:54ZStructures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones10.1038/s41467-018-06192-32041-1723https://doaj.org/article/ab49da7df68b46db823e2dfac264e41c2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06192-3https://doaj.org/toc/2041-1723Insulin-like polypeptide binding proteins (IBPs) from insects can bind diverse insulin-like proteins (ILPs) including human insulin and IGFs. Here, the authors present structures of a Drosophila IBP in its free and ILP-bound forms, providing insights into the regulation of ILP bioavailability by insect IBPs.Nikolaj Kulahin RoedCristina M. ViolaOle KristensenGerd SchluckebierMathias NorrmanWaseem SajidJohn D. WadeAsser Sloth AndersenClaus KristensenTimothy R. GandertonJohan P. TurkenburgPierre De MeytsAndrzej M. BrzozowskiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nikolaj Kulahin Roed Cristina M. Viola Ole Kristensen Gerd Schluckebier Mathias Norrman Waseem Sajid John D. Wade Asser Sloth Andersen Claus Kristensen Timothy R. Ganderton Johan P. Turkenburg Pierre De Meyts Andrzej M. Brzozowski Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones
description	Insulin-like polypeptide binding proteins (IBPs) from insects can bind diverse insulin-like proteins (ILPs) including human insulin and IGFs. Here, the authors present structures of a Drosophila IBP in its free and ILP-bound forms, providing insights into the regulation of ILP bioavailability by insect IBPs.
format	article
author	Nikolaj Kulahin Roed Cristina M. Viola Ole Kristensen Gerd Schluckebier Mathias Norrman Waseem Sajid John D. Wade Asser Sloth Andersen Claus Kristensen Timothy R. Ganderton Johan P. Turkenburg Pierre De Meyts Andrzej M. Brzozowski
author_facet	Nikolaj Kulahin Roed Cristina M. Viola Ole Kristensen Gerd Schluckebier Mathias Norrman Waseem Sajid John D. Wade Asser Sloth Andersen Claus Kristensen Timothy R. Ganderton Johan P. Turkenburg Pierre De Meyts Andrzej M. Brzozowski
author_sort	Nikolaj Kulahin Roed
title	Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones
title_short	Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones
title_full	Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones
title_fullStr	Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones
title_full_unstemmed	Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones
title_sort	structures of insect imp-l2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ab49da7df68b46db823e2dfac264e41c
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Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones

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