Factors associated with assisted ventilation use in amyotrophic lateral sclerosis: a nationwide population-based study in Korea

Abstract Few studies have investigated the factors associated with assisted ventilation use in amyotrophic lateral sclerosis (ALS) in western countries with a relatively small number of participants. This study aimed to evaluate the factors associated with assisted ventilation use using a large nati...

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Autores principales: Seo Yeon Yoon, Han-Kyoul Kim, Mi Ji Kim, Jee Hyun Suh, Ja-Ho Leigh
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/ab4a4efa45c444ba8191888d0d906857
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spelling oai:doaj.org-article:ab4a4efa45c444ba8191888d0d9068572021-12-02T16:57:08ZFactors associated with assisted ventilation use in amyotrophic lateral sclerosis: a nationwide population-based study in Korea10.1038/s41598-021-98990-x2045-2322https://doaj.org/article/ab4a4efa45c444ba8191888d0d9068572021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98990-xhttps://doaj.org/toc/2045-2322Abstract Few studies have investigated the factors associated with assisted ventilation use in amyotrophic lateral sclerosis (ALS) in western countries with a relatively small number of participants. This study aimed to evaluate the factors associated with assisted ventilation use using a large nationwide cohort covering the entire Korean population. We selected patients with primary or secondary diagnoses of ALS (ICD-10 code: G12.21) and a registration code for ALS (V123) in the rare intractable disease registration program. Covariates included in the analyses were age, sex, socioeconomic status and medical condition. Factors associated with non-invasive ventilation (NIV) and tracheostomy invasive ventilation (TIV) were evaluated. Logistic regression analyses were performed using odds ratios and 95% confidence intervals. In total, 3057 patients with ALS were enrolled. During the 6-year follow-up period, 1228 (40%) patients started using assisted ventilation: 956 with NIV and 272 with TIV. There was no significant difference in the assisted ventilation use according to sex, whereas different patterns of discrepancies were noted between the sexes: Females living in non-metropolitan areas showed decreased use of assisted ventilation, whereas high income levels showed a positive relationship with assisted ventilation use only in males. Patients aged ≥ 70 years showed decreased use of NIV. NIV use was more affected by socioeconomic status than TIV, whereas TIV showed a significant relationship with medical conditions such as nasogastric tube insertion and gastrostomy. We found that various factors, including age, socioeconomic status, and medical condition, were related with assisted ventilation use. Understanding the pattern of assisted ventilation use would help set optimal management strategies in patients with ALS.Seo Yeon YoonHan-Kyoul KimMi Ji KimJee Hyun SuhJa-Ho LeighNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Seo Yeon Yoon
Han-Kyoul Kim
Mi Ji Kim
Jee Hyun Suh
Ja-Ho Leigh
Factors associated with assisted ventilation use in amyotrophic lateral sclerosis: a nationwide population-based study in Korea
description Abstract Few studies have investigated the factors associated with assisted ventilation use in amyotrophic lateral sclerosis (ALS) in western countries with a relatively small number of participants. This study aimed to evaluate the factors associated with assisted ventilation use using a large nationwide cohort covering the entire Korean population. We selected patients with primary or secondary diagnoses of ALS (ICD-10 code: G12.21) and a registration code for ALS (V123) in the rare intractable disease registration program. Covariates included in the analyses were age, sex, socioeconomic status and medical condition. Factors associated with non-invasive ventilation (NIV) and tracheostomy invasive ventilation (TIV) were evaluated. Logistic regression analyses were performed using odds ratios and 95% confidence intervals. In total, 3057 patients with ALS were enrolled. During the 6-year follow-up period, 1228 (40%) patients started using assisted ventilation: 956 with NIV and 272 with TIV. There was no significant difference in the assisted ventilation use according to sex, whereas different patterns of discrepancies were noted between the sexes: Females living in non-metropolitan areas showed decreased use of assisted ventilation, whereas high income levels showed a positive relationship with assisted ventilation use only in males. Patients aged ≥ 70 years showed decreased use of NIV. NIV use was more affected by socioeconomic status than TIV, whereas TIV showed a significant relationship with medical conditions such as nasogastric tube insertion and gastrostomy. We found that various factors, including age, socioeconomic status, and medical condition, were related with assisted ventilation use. Understanding the pattern of assisted ventilation use would help set optimal management strategies in patients with ALS.
format article
author Seo Yeon Yoon
Han-Kyoul Kim
Mi Ji Kim
Jee Hyun Suh
Ja-Ho Leigh
author_facet Seo Yeon Yoon
Han-Kyoul Kim
Mi Ji Kim
Jee Hyun Suh
Ja-Ho Leigh
author_sort Seo Yeon Yoon
title Factors associated with assisted ventilation use in amyotrophic lateral sclerosis: a nationwide population-based study in Korea
title_short Factors associated with assisted ventilation use in amyotrophic lateral sclerosis: a nationwide population-based study in Korea
title_full Factors associated with assisted ventilation use in amyotrophic lateral sclerosis: a nationwide population-based study in Korea
title_fullStr Factors associated with assisted ventilation use in amyotrophic lateral sclerosis: a nationwide population-based study in Korea
title_full_unstemmed Factors associated with assisted ventilation use in amyotrophic lateral sclerosis: a nationwide population-based study in Korea
title_sort factors associated with assisted ventilation use in amyotrophic lateral sclerosis: a nationwide population-based study in korea
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/ab4a4efa45c444ba8191888d0d906857
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