Factors associated with assisted ventilation use in amyotrophic lateral sclerosis: a nationwide population-based study in Korea

Abstract Few studies have investigated the factors associated with assisted ventilation use in amyotrophic lateral sclerosis (ALS) in western countries with a relatively small number of participants. This study aimed to evaluate the factors associated with assisted ventilation use using a large nati...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Seo Yeon Yoon, Han-Kyoul Kim, Mi Ji Kim, Jee Hyun Suh, Ja-Ho Leigh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ab4a4efa45c444ba8191888d0d906857
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ab4a4efa45c444ba8191888d0d906857
record_format	dspace
spelling	oai:doaj.org-article:ab4a4efa45c444ba8191888d0d9068572021-12-02T16:57:08ZFactors associated with assisted ventilation use in amyotrophic lateral sclerosis: a nationwide population-based study in Korea10.1038/s41598-021-98990-x2045-2322https://doaj.org/article/ab4a4efa45c444ba8191888d0d9068572021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98990-xhttps://doaj.org/toc/2045-2322Abstract Few studies have investigated the factors associated with assisted ventilation use in amyotrophic lateral sclerosis (ALS) in western countries with a relatively small number of participants. This study aimed to evaluate the factors associated with assisted ventilation use using a large nationwide cohort covering the entire Korean population. We selected patients with primary or secondary diagnoses of ALS (ICD-10 code: G12.21) and a registration code for ALS (V123) in the rare intractable disease registration program. Covariates included in the analyses were age, sex, socioeconomic status and medical condition. Factors associated with non-invasive ventilation (NIV) and tracheostomy invasive ventilation (TIV) were evaluated. Logistic regression analyses were performed using odds ratios and 95% confidence intervals. In total, 3057 patients with ALS were enrolled. During the 6-year follow-up period, 1228 (40%) patients started using assisted ventilation: 956 with NIV and 272 with TIV. There was no significant difference in the assisted ventilation use according to sex, whereas different patterns of discrepancies were noted between the sexes: Females living in non-metropolitan areas showed decreased use of assisted ventilation, whereas high income levels showed a positive relationship with assisted ventilation use only in males. Patients aged ≥ 70 years showed decreased use of NIV. NIV use was more affected by socioeconomic status than TIV, whereas TIV showed a significant relationship with medical conditions such as nasogastric tube insertion and gastrostomy. We found that various factors, including age, socioeconomic status, and medical condition, were related with assisted ventilation use. Understanding the pattern of assisted ventilation use would help set optimal management strategies in patients with ALS.Seo Yeon YoonHan-Kyoul KimMi Ji KimJee Hyun SuhJa-Ho LeighNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seo Yeon Yoon Han-Kyoul Kim Mi Ji Kim Jee Hyun Suh Ja-Ho Leigh Factors associated with assisted ventilation use in amyotrophic lateral sclerosis: a nationwide population-based study in Korea
description	Abstract Few studies have investigated the factors associated with assisted ventilation use in amyotrophic lateral sclerosis (ALS) in western countries with a relatively small number of participants. This study aimed to evaluate the factors associated with assisted ventilation use using a large nationwide cohort covering the entire Korean population. We selected patients with primary or secondary diagnoses of ALS (ICD-10 code: G12.21) and a registration code for ALS (V123) in the rare intractable disease registration program. Covariates included in the analyses were age, sex, socioeconomic status and medical condition. Factors associated with non-invasive ventilation (NIV) and tracheostomy invasive ventilation (TIV) were evaluated. Logistic regression analyses were performed using odds ratios and 95% confidence intervals. In total, 3057 patients with ALS were enrolled. During the 6-year follow-up period, 1228 (40%) patients started using assisted ventilation: 956 with NIV and 272 with TIV. There was no significant difference in the assisted ventilation use according to sex, whereas different patterns of discrepancies were noted between the sexes: Females living in non-metropolitan areas showed decreased use of assisted ventilation, whereas high income levels showed a positive relationship with assisted ventilation use only in males. Patients aged ≥ 70 years showed decreased use of NIV. NIV use was more affected by socioeconomic status than TIV, whereas TIV showed a significant relationship with medical conditions such as nasogastric tube insertion and gastrostomy. We found that various factors, including age, socioeconomic status, and medical condition, were related with assisted ventilation use. Understanding the pattern of assisted ventilation use would help set optimal management strategies in patients with ALS.
format	article
author	Seo Yeon Yoon Han-Kyoul Kim Mi Ji Kim Jee Hyun Suh Ja-Ho Leigh
author_facet	Seo Yeon Yoon Han-Kyoul Kim Mi Ji Kim Jee Hyun Suh Ja-Ho Leigh
author_sort	Seo Yeon Yoon
title	Factors associated with assisted ventilation use in amyotrophic lateral sclerosis: a nationwide population-based study in Korea
title_short	Factors associated with assisted ventilation use in amyotrophic lateral sclerosis: a nationwide population-based study in Korea
title_full	Factors associated with assisted ventilation use in amyotrophic lateral sclerosis: a nationwide population-based study in Korea
title_fullStr	Factors associated with assisted ventilation use in amyotrophic lateral sclerosis: a nationwide population-based study in Korea
title_full_unstemmed	Factors associated with assisted ventilation use in amyotrophic lateral sclerosis: a nationwide population-based study in Korea
title_sort	factors associated with assisted ventilation use in amyotrophic lateral sclerosis: a nationwide population-based study in korea
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ab4a4efa45c444ba8191888d0d906857
work_keys_str_mv	AT seoyeonyoon factorsassociatedwithassistedventilationuseinamyotrophiclateralsclerosisanationwidepopulationbasedstudyinkorea AT hankyoulkim factorsassociatedwithassistedventilationuseinamyotrophiclateralsclerosisanationwidepopulationbasedstudyinkorea AT mijikim factorsassociatedwithassistedventilationuseinamyotrophiclateralsclerosisanationwidepopulationbasedstudyinkorea AT jeehyunsuh factorsassociatedwithassistedventilationuseinamyotrophiclateralsclerosisanationwidepopulationbasedstudyinkorea AT jaholeigh factorsassociatedwithassistedventilationuseinamyotrophiclateralsclerosisanationwidepopulationbasedstudyinkorea
_version_	1718382641371152384

Factors associated with assisted ventilation use in amyotrophic lateral sclerosis: a nationwide population-based study in Korea

Ejemplares similares