CELLULAR GENOME IN PATHOGENESIS OF BASIC DISEASES IN HUMANS (ATHEROSCLEROSIS, AUTOIMMUNE DISEASES, CANCER)

Despite of considerable differences in etiology, pathogenesis, clinical and laboratory, data, and, finally, different clinical features of such diseases as atherosclerosis, autoimmune and allergic diseases, there exists a lot of evidence suggesting that, basically, these disorders have much in commo...

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Autor principal:	V. A. Kozlov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	genome methylation atherosclerosis telomere cancer Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/ab4adbf9386946aa9e5c93f608619f89
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spelling	oai:doaj.org-article:ab4adbf9386946aa9e5c93f608619f892021-11-18T08:03:38ZCELLULAR GENOME IN PATHOGENESIS OF BASIC DISEASES IN HUMANS (ATHEROSCLEROSIS, AUTOIMMUNE DISEASES, CANCER)1563-06252313-741X10.15789/1563-0625-2010-4-5-285-296https://doaj.org/article/ab4adbf9386946aa9e5c93f608619f892014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/125https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XDespite of considerable differences in etiology, pathogenesis, clinical and laboratory, data, and, finally, different clinical features of such diseases as atherosclerosis, autoimmune and allergic diseases, there exists a lot of evidence suggesting that, basically, these disorders have much in common. First of all, it concerns epigenetic regulatory mechanisms of gene expression that show virtually identical patterns of changes, i.e., total hypomethylation and reversible hypermethylation of distinct genes. The events connected with regulation of telomere length are also similar in all the mentioned disorders. In general, this concept draws attention to current needs for urgent development of novel therapeutic approaches for these very common disorders, by means of drugs that would be able to influence some molecular mechanisms, underlying epigenetic regulation of gene expression.V. A. KozlovSPb RAACIarticlegenomemethylationatherosclerosistelomerecancerImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 4-5, Pp 285-296 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	genome methylation atherosclerosis telomere cancer Immunologic diseases. Allergy RC581-607
spellingShingle	genome methylation atherosclerosis telomere cancer Immunologic diseases. Allergy RC581-607 V. A. Kozlov CELLULAR GENOME IN PATHOGENESIS OF BASIC DISEASES IN HUMANS (ATHEROSCLEROSIS, AUTOIMMUNE DISEASES, CANCER)
description	Despite of considerable differences in etiology, pathogenesis, clinical and laboratory, data, and, finally, different clinical features of such diseases as atherosclerosis, autoimmune and allergic diseases, there exists a lot of evidence suggesting that, basically, these disorders have much in common. First of all, it concerns epigenetic regulatory mechanisms of gene expression that show virtually identical patterns of changes, i.e., total hypomethylation and reversible hypermethylation of distinct genes. The events connected with regulation of telomere length are also similar in all the mentioned disorders. In general, this concept draws attention to current needs for urgent development of novel therapeutic approaches for these very common disorders, by means of drugs that would be able to influence some molecular mechanisms, underlying epigenetic regulation of gene expression.
format	article
author	V. A. Kozlov
author_facet	V. A. Kozlov
author_sort	V. A. Kozlov
title	CELLULAR GENOME IN PATHOGENESIS OF BASIC DISEASES IN HUMANS (ATHEROSCLEROSIS, AUTOIMMUNE DISEASES, CANCER)
title_short	CELLULAR GENOME IN PATHOGENESIS OF BASIC DISEASES IN HUMANS (ATHEROSCLEROSIS, AUTOIMMUNE DISEASES, CANCER)
title_full	CELLULAR GENOME IN PATHOGENESIS OF BASIC DISEASES IN HUMANS (ATHEROSCLEROSIS, AUTOIMMUNE DISEASES, CANCER)
title_fullStr	CELLULAR GENOME IN PATHOGENESIS OF BASIC DISEASES IN HUMANS (ATHEROSCLEROSIS, AUTOIMMUNE DISEASES, CANCER)
title_full_unstemmed	CELLULAR GENOME IN PATHOGENESIS OF BASIC DISEASES IN HUMANS (ATHEROSCLEROSIS, AUTOIMMUNE DISEASES, CANCER)
title_sort	cellular genome in pathogenesis of basic diseases in humans (atherosclerosis, autoimmune diseases, cancer)
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/ab4adbf9386946aa9e5c93f608619f89
work_keys_str_mv	AT vakozlov cellulargenomeinpathogenesisofbasicdiseasesinhumansatherosclerosisautoimmunediseasescancer
_version_	1718422563157180416

CELLULAR GENOME IN PATHOGENESIS OF BASIC DISEASES IN HUMANS (ATHEROSCLEROSIS, AUTOIMMUNE DISEASES, CANCER)

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