Epigenetic modifications of embryonic stem cells: current trends and relevance in developing regenerative medicine

Henry Chung, Kuldip S SidhuStem Cell Lab, Faculty of Medicine, School of Psychiatry, University of New South Wales, Sydney, NSW, AustraliaAbstract: Epigenetics is a growing field not only in the area of cancer research but recently in stem cells including human embryonic stem cell (hESC) research. T...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Henry Chung, Kuldip S Sidhu
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/ab50bc19a7bb48d1bedae27bb06114f3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ab50bc19a7bb48d1bedae27bb06114f3
record_format	dspace
spelling	oai:doaj.org-article:ab50bc19a7bb48d1bedae27bb06114f32021-12-02T11:28:16ZEpigenetic modifications of embryonic stem cells: current trends and relevance in developing regenerative medicine1178-6957https://doaj.org/article/ab50bc19a7bb48d1bedae27bb06114f32008-11-01T00:00:00Zhttp://www.dovepress.com/epigenetic-modifications-of-embryonic-stem-cells-current-trends-and-re-a2584https://doaj.org/toc/1178-6957Henry Chung, Kuldip S SidhuStem Cell Lab, Faculty of Medicine, School of Psychiatry, University of New South Wales, Sydney, NSW, AustraliaAbstract: Epigenetics is a growing field not only in the area of cancer research but recently in stem cells including human embryonic stem cell (hESC) research. The hallmark of profiling epigenetic changes in stem cells lies in maintaining pluripotency or multipotency and in attaining lineage specifications that are relevant for regenerative medicine. Epigenetic modifications including DNA methylation, histone acetylation and methylation, play important roles in regulating gene expressions. Other epigenetic modifications include X chromosome silencing, genomic stability and imprinting and mammalian development. This review attempts to elucidate the mechanism(s) behind epigenetic modifications and review techniques scientists use for identifying each modification. We also discuss some of the trends of epigenetic modifications in the fields of directed differentiation of embryonic stem cells and de-differentiation of somatic cells.Keywords: epigenetics, embryonic stem cell, somatic cell nuclear transfer, DNA methylation, chromatin modifications Henry ChungKuldip S SidhuDove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2008, Iss default, Pp 11-21 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Henry Chung Kuldip S Sidhu Epigenetic modifications of embryonic stem cells: current trends and relevance in developing regenerative medicine
description	Henry Chung, Kuldip S SidhuStem Cell Lab, Faculty of Medicine, School of Psychiatry, University of New South Wales, Sydney, NSW, AustraliaAbstract: Epigenetics is a growing field not only in the area of cancer research but recently in stem cells including human embryonic stem cell (hESC) research. The hallmark of profiling epigenetic changes in stem cells lies in maintaining pluripotency or multipotency and in attaining lineage specifications that are relevant for regenerative medicine. Epigenetic modifications including DNA methylation, histone acetylation and methylation, play important roles in regulating gene expressions. Other epigenetic modifications include X chromosome silencing, genomic stability and imprinting and mammalian development. This review attempts to elucidate the mechanism(s) behind epigenetic modifications and review techniques scientists use for identifying each modification. We also discuss some of the trends of epigenetic modifications in the fields of directed differentiation of embryonic stem cells and de-differentiation of somatic cells.Keywords: epigenetics, embryonic stem cell, somatic cell nuclear transfer, DNA methylation, chromatin modifications
format	article
author	Henry Chung Kuldip S Sidhu
author_facet	Henry Chung Kuldip S Sidhu
author_sort	Henry Chung
title	Epigenetic modifications of embryonic stem cells: current trends and relevance in developing regenerative medicine
title_short	Epigenetic modifications of embryonic stem cells: current trends and relevance in developing regenerative medicine
title_full	Epigenetic modifications of embryonic stem cells: current trends and relevance in developing regenerative medicine
title_fullStr	Epigenetic modifications of embryonic stem cells: current trends and relevance in developing regenerative medicine
title_full_unstemmed	Epigenetic modifications of embryonic stem cells: current trends and relevance in developing regenerative medicine
title_sort	epigenetic modifications of embryonic stem cells: current trends and relevance in developing regenerative medicine
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/ab50bc19a7bb48d1bedae27bb06114f3
work_keys_str_mv	AT henrychung epigeneticmodificationsofembryonicstemcellscurrenttrendsandrelevanceindevelopingregenerativemedicine AT kuldipssidhu epigeneticmodificationsofembryonicstemcellscurrenttrendsandrelevanceindevelopingregenerativemedicine
_version_	1718395899065925632

Epigenetic modifications of embryonic stem cells: current trends and relevance in developing regenerative medicine

Ejemplares similares