Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma
Venetoclax monotherapy is effective in 40% of t(11:14) positive multiple myeloma (MM). Here, the authors show that electron transport chain complex I (CI) and complex II (CII) activity predict MM sensitivity to venetoclax, and inhibition of CI with IACS-010759 or CII with TTFA increase sensitivity.
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Nature Portfolio
2020
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| Acceso en línea: | https://doaj.org/article/ab542c51a366402d8b83cd98c687f243 |
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oai:doaj.org-article:ab542c51a366402d8b83cd98c687f2432021-12-02T14:41:23ZElectron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma10.1038/s41467-020-15051-z2041-1723https://doaj.org/article/ab542c51a366402d8b83cd98c687f2432020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15051-zhttps://doaj.org/toc/2041-1723Venetoclax monotherapy is effective in 40% of t(11:14) positive multiple myeloma (MM). Here, the authors show that electron transport chain complex I (CI) and complex II (CII) activity predict MM sensitivity to venetoclax, and inhibition of CI with IACS-010759 or CII with TTFA increase sensitivity.Richa BajpaiAditi SharmaAbhinav AchrejaClaudia L. EdgarChangyong WeiArusha A. SiddiqaVikas A. GuptaShannon M. MatulisSamuel K. McBrayerAnjali MittalManali RupjiBenjamin G. BarwickSagar LonialAjay K. NookaLawrence H. BoiseDeepak NagrathMala ShanmugamNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Richa Bajpai Aditi Sharma Abhinav Achreja Claudia L. Edgar Changyong Wei Arusha A. Siddiqa Vikas A. Gupta Shannon M. Matulis Samuel K. McBrayer Anjali Mittal Manali Rupji Benjamin G. Barwick Sagar Lonial Ajay K. Nooka Lawrence H. Boise Deepak Nagrath Mala Shanmugam Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma |
| description |
Venetoclax monotherapy is effective in 40% of t(11:14) positive multiple myeloma (MM). Here, the authors show that electron transport chain complex I (CI) and complex II (CII) activity predict MM sensitivity to venetoclax, and inhibition of CI with IACS-010759 or CII with TTFA increase sensitivity. |
| format |
article |
| author |
Richa Bajpai Aditi Sharma Abhinav Achreja Claudia L. Edgar Changyong Wei Arusha A. Siddiqa Vikas A. Gupta Shannon M. Matulis Samuel K. McBrayer Anjali Mittal Manali Rupji Benjamin G. Barwick Sagar Lonial Ajay K. Nooka Lawrence H. Boise Deepak Nagrath Mala Shanmugam |
| author_facet |
Richa Bajpai Aditi Sharma Abhinav Achreja Claudia L. Edgar Changyong Wei Arusha A. Siddiqa Vikas A. Gupta Shannon M. Matulis Samuel K. McBrayer Anjali Mittal Manali Rupji Benjamin G. Barwick Sagar Lonial Ajay K. Nooka Lawrence H. Boise Deepak Nagrath Mala Shanmugam |
| author_sort |
Richa Bajpai |
| title |
Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma |
| title_short |
Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma |
| title_full |
Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma |
| title_fullStr |
Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma |
| title_full_unstemmed |
Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma |
| title_sort |
electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/ab542c51a366402d8b83cd98c687f243 |
| work_keys_str_mv |
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1718389889838350336 |