Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging

Abstract Cerebral aneurysms are potentially life threatening and nowadays treated by a catheter-guided coiling or by a neurosurgical clipping intervention. Here, we propose a helically shaped magnetic micro-robot, which can be steered by magnetic fields in an untethered manner and could be applied f...

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Autores principales: Anna C. Bakenecker, Anselm von Gladiss, Hannes Schwenke, André Behrends, Thomas Friedrich, Kerstin Lüdtke-Buzug, Alexander Neumann, Joerg Barkhausen, Franz Wegner, Thorsten M. Buzug
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/ab54bde244bd4ddb91ffcd4de91f0f13
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spelling oai:doaj.org-article:ab54bde244bd4ddb91ffcd4de91f0f132021-12-02T15:22:57ZNavigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging10.1038/s41598-021-93323-42045-2322https://doaj.org/article/ab54bde244bd4ddb91ffcd4de91f0f132021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93323-4https://doaj.org/toc/2045-2322Abstract Cerebral aneurysms are potentially life threatening and nowadays treated by a catheter-guided coiling or by a neurosurgical clipping intervention. Here, we propose a helically shaped magnetic micro-robot, which can be steered by magnetic fields in an untethered manner and could be applied for a novel coiling procedure. This is shown by navigating the micro-robot through an additively manufactured phantom of a human cerebral aneurysm. The magnetic fields are applied with a magnetic particle imaging (MPI) scanner, which allows for the navigation and tomographic visualization by the same machine. With MPI the actuation process can be visualized with a localization accuracy of 0.68 mm and an angiogram can be acquired both without any radiation exposure. First in-vitro phantom experiments are presented, showing an idea of a robot conducted treatment of cerebral aneurysms.Anna C. BakeneckerAnselm von GladissHannes SchwenkeAndré BehrendsThomas FriedrichKerstin Lüdtke-BuzugAlexander NeumannJoerg BarkhausenFranz WegnerThorsten M. BuzugNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Anna C. Bakenecker
Anselm von Gladiss
Hannes Schwenke
André Behrends
Thomas Friedrich
Kerstin Lüdtke-Buzug
Alexander Neumann
Joerg Barkhausen
Franz Wegner
Thorsten M. Buzug
Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging
description Abstract Cerebral aneurysms are potentially life threatening and nowadays treated by a catheter-guided coiling or by a neurosurgical clipping intervention. Here, we propose a helically shaped magnetic micro-robot, which can be steered by magnetic fields in an untethered manner and could be applied for a novel coiling procedure. This is shown by navigating the micro-robot through an additively manufactured phantom of a human cerebral aneurysm. The magnetic fields are applied with a magnetic particle imaging (MPI) scanner, which allows for the navigation and tomographic visualization by the same machine. With MPI the actuation process can be visualized with a localization accuracy of 0.68 mm and an angiogram can be acquired both without any radiation exposure. First in-vitro phantom experiments are presented, showing an idea of a robot conducted treatment of cerebral aneurysms.
format article
author Anna C. Bakenecker
Anselm von Gladiss
Hannes Schwenke
André Behrends
Thomas Friedrich
Kerstin Lüdtke-Buzug
Alexander Neumann
Joerg Barkhausen
Franz Wegner
Thorsten M. Buzug
author_facet Anna C. Bakenecker
Anselm von Gladiss
Hannes Schwenke
André Behrends
Thomas Friedrich
Kerstin Lüdtke-Buzug
Alexander Neumann
Joerg Barkhausen
Franz Wegner
Thorsten M. Buzug
author_sort Anna C. Bakenecker
title Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging
title_short Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging
title_full Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging
title_fullStr Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging
title_full_unstemmed Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging
title_sort navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/ab54bde244bd4ddb91ffcd4de91f0f13
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