Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging
Abstract Cerebral aneurysms are potentially life threatening and nowadays treated by a catheter-guided coiling or by a neurosurgical clipping intervention. Here, we propose a helically shaped magnetic micro-robot, which can be steered by magnetic fields in an untethered manner and could be applied f...
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Nature Portfolio
2021
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oai:doaj.org-article:ab54bde244bd4ddb91ffcd4de91f0f132021-12-02T15:22:57ZNavigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging10.1038/s41598-021-93323-42045-2322https://doaj.org/article/ab54bde244bd4ddb91ffcd4de91f0f132021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93323-4https://doaj.org/toc/2045-2322Abstract Cerebral aneurysms are potentially life threatening and nowadays treated by a catheter-guided coiling or by a neurosurgical clipping intervention. Here, we propose a helically shaped magnetic micro-robot, which can be steered by magnetic fields in an untethered manner and could be applied for a novel coiling procedure. This is shown by navigating the micro-robot through an additively manufactured phantom of a human cerebral aneurysm. The magnetic fields are applied with a magnetic particle imaging (MPI) scanner, which allows for the navigation and tomographic visualization by the same machine. With MPI the actuation process can be visualized with a localization accuracy of 0.68 mm and an angiogram can be acquired both without any radiation exposure. First in-vitro phantom experiments are presented, showing an idea of a robot conducted treatment of cerebral aneurysms.Anna C. BakeneckerAnselm von GladissHannes SchwenkeAndré BehrendsThomas FriedrichKerstin Lüdtke-BuzugAlexander NeumannJoerg BarkhausenFranz WegnerThorsten M. BuzugNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) |
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Medicine R Science Q Anna C. Bakenecker Anselm von Gladiss Hannes Schwenke André Behrends Thomas Friedrich Kerstin Lüdtke-Buzug Alexander Neumann Joerg Barkhausen Franz Wegner Thorsten M. Buzug Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging |
description |
Abstract Cerebral aneurysms are potentially life threatening and nowadays treated by a catheter-guided coiling or by a neurosurgical clipping intervention. Here, we propose a helically shaped magnetic micro-robot, which can be steered by magnetic fields in an untethered manner and could be applied for a novel coiling procedure. This is shown by navigating the micro-robot through an additively manufactured phantom of a human cerebral aneurysm. The magnetic fields are applied with a magnetic particle imaging (MPI) scanner, which allows for the navigation and tomographic visualization by the same machine. With MPI the actuation process can be visualized with a localization accuracy of 0.68 mm and an angiogram can be acquired both without any radiation exposure. First in-vitro phantom experiments are presented, showing an idea of a robot conducted treatment of cerebral aneurysms. |
format |
article |
author |
Anna C. Bakenecker Anselm von Gladiss Hannes Schwenke André Behrends Thomas Friedrich Kerstin Lüdtke-Buzug Alexander Neumann Joerg Barkhausen Franz Wegner Thorsten M. Buzug |
author_facet |
Anna C. Bakenecker Anselm von Gladiss Hannes Schwenke André Behrends Thomas Friedrich Kerstin Lüdtke-Buzug Alexander Neumann Joerg Barkhausen Franz Wegner Thorsten M. Buzug |
author_sort |
Anna C. Bakenecker |
title |
Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging |
title_short |
Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging |
title_full |
Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging |
title_fullStr |
Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging |
title_full_unstemmed |
Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging |
title_sort |
navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/ab54bde244bd4ddb91ffcd4de91f0f13 |
work_keys_str_mv |
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