Non-motor symptoms in patients with Parkinson's disease - correlations with inflammatory cytokines in serum.

<h4>Background</h4>Parkinson's Disease (PD) is the second most common neurodegenerative disorder of the central nervous system. Motor symptoms are the focus of pharmacotherapy, yet non-motor features of the disease (e.g. fatigue, mood disturbances, sleep disturbances and symptoms of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Daniel Lindqvist, Eli Kaufman, Lena Brundin, Sara Hall, Yulia Surova, Oskar Hansson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ab5856f4667041cbacf1f2b0b93c6f31
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ab5856f4667041cbacf1f2b0b93c6f31
record_format	dspace
spelling	oai:doaj.org-article:ab5856f4667041cbacf1f2b0b93c6f312021-11-18T08:11:41ZNon-motor symptoms in patients with Parkinson's disease - correlations with inflammatory cytokines in serum.1932-620310.1371/journal.pone.0047387https://doaj.org/article/ab5856f4667041cbacf1f2b0b93c6f312012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23082161/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Parkinson's Disease (PD) is the second most common neurodegenerative disorder of the central nervous system. Motor symptoms are the focus of pharmacotherapy, yet non-motor features of the disease (e.g. fatigue, mood disturbances, sleep disturbances and symptoms of anxiety) are both common and disabling for the patient. The pathophysiological mechanisms behind the non-motor symptoms in PD are yet to be untangled. The main objective of this study was to investigate associations between pro-inflammatory substances and non-motor symptoms in patients with PD.<h4>Methods and materials</h4>We measured C-reactive protein, interleukin (IL)-6, soluble IL-2 receptor (sIL-2R) and tumor necrosis factor-α (TNF-α) in blood samples from PD patients (n=86) and healthy controls (n=40). Symptoms of fatigue, depression, anxiety and sleeping difficulties were assessed using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT), the Hospital Anxiety and Depression Scale (HAD), and the Scales for Outcome in PD-Sleep Scale respectively.<h4>Results</h4>IL-6 was significantly higher in PD patients than in healthy controls. Compared to healthy controls, PD patients displayed significantly higher mean scores on HAD and lower scores on FACIT, thus indicating more severe symptoms as measured with these scales. Within the PD sample, high levels of both sIL-2R and TNF-α were significantly associated with more severe symptoms assessed by means of FACIT and HAD (depression and anxiety subscales). SIL-2-R levels were able to significantly predict FACIT and HAD scores after the effects of age, gender, anti-parkinsonian medications, and severity of motor symptoms were controlled for.<h4>Discussion</h4>We suggest that non-motor symptoms in PD patients, such as fatigue and depressive symptoms, might be generated via inflammatory mechanisms. This knowledge might contribute to the development of novel treatment options in PD, specifically targeting non-motor symptoms.Daniel LindqvistEli KaufmanLena BrundinSara HallYulia SurovaOskar HanssonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e47387 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniel Lindqvist Eli Kaufman Lena Brundin Sara Hall Yulia Surova Oskar Hansson Non-motor symptoms in patients with Parkinson's disease - correlations with inflammatory cytokines in serum.
description	<h4>Background</h4>Parkinson's Disease (PD) is the second most common neurodegenerative disorder of the central nervous system. Motor symptoms are the focus of pharmacotherapy, yet non-motor features of the disease (e.g. fatigue, mood disturbances, sleep disturbances and symptoms of anxiety) are both common and disabling for the patient. The pathophysiological mechanisms behind the non-motor symptoms in PD are yet to be untangled. The main objective of this study was to investigate associations between pro-inflammatory substances and non-motor symptoms in patients with PD.<h4>Methods and materials</h4>We measured C-reactive protein, interleukin (IL)-6, soluble IL-2 receptor (sIL-2R) and tumor necrosis factor-α (TNF-α) in blood samples from PD patients (n=86) and healthy controls (n=40). Symptoms of fatigue, depression, anxiety and sleeping difficulties were assessed using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT), the Hospital Anxiety and Depression Scale (HAD), and the Scales for Outcome in PD-Sleep Scale respectively.<h4>Results</h4>IL-6 was significantly higher in PD patients than in healthy controls. Compared to healthy controls, PD patients displayed significantly higher mean scores on HAD and lower scores on FACIT, thus indicating more severe symptoms as measured with these scales. Within the PD sample, high levels of both sIL-2R and TNF-α were significantly associated with more severe symptoms assessed by means of FACIT and HAD (depression and anxiety subscales). SIL-2-R levels were able to significantly predict FACIT and HAD scores after the effects of age, gender, anti-parkinsonian medications, and severity of motor symptoms were controlled for.<h4>Discussion</h4>We suggest that non-motor symptoms in PD patients, such as fatigue and depressive symptoms, might be generated via inflammatory mechanisms. This knowledge might contribute to the development of novel treatment options in PD, specifically targeting non-motor symptoms.
format	article
author	Daniel Lindqvist Eli Kaufman Lena Brundin Sara Hall Yulia Surova Oskar Hansson
author_facet	Daniel Lindqvist Eli Kaufman Lena Brundin Sara Hall Yulia Surova Oskar Hansson
author_sort	Daniel Lindqvist
title	Non-motor symptoms in patients with Parkinson's disease - correlations with inflammatory cytokines in serum.
title_short	Non-motor symptoms in patients with Parkinson's disease - correlations with inflammatory cytokines in serum.
title_full	Non-motor symptoms in patients with Parkinson's disease - correlations with inflammatory cytokines in serum.
title_fullStr	Non-motor symptoms in patients with Parkinson's disease - correlations with inflammatory cytokines in serum.
title_full_unstemmed	Non-motor symptoms in patients with Parkinson's disease - correlations with inflammatory cytokines in serum.
title_sort	non-motor symptoms in patients with parkinson's disease - correlations with inflammatory cytokines in serum.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/ab5856f4667041cbacf1f2b0b93c6f31
work_keys_str_mv	AT daniellindqvist nonmotorsymptomsinpatientswithparkinsonsdiseasecorrelationswithinflammatorycytokinesinserum AT elikaufman nonmotorsymptomsinpatientswithparkinsonsdiseasecorrelationswithinflammatorycytokinesinserum AT lenabrundin nonmotorsymptomsinpatientswithparkinsonsdiseasecorrelationswithinflammatorycytokinesinserum AT sarahall nonmotorsymptomsinpatientswithparkinsonsdiseasecorrelationswithinflammatorycytokinesinserum AT yuliasurova nonmotorsymptomsinpatientswithparkinsonsdiseasecorrelationswithinflammatorycytokinesinserum AT oskarhansson nonmotorsymptomsinpatientswithparkinsonsdiseasecorrelationswithinflammatorycytokinesinserum
_version_	1718422064823533568

Non-motor symptoms in patients with Parkinson's disease - correlations with inflammatory cytokines in serum.

Ejemplares similares