The effect of prepregnancy body mass index on maternal micronutrient status: a meta-analysis

Abstract The relationship between prepregnancy body mass index (BMI) and maternal micronutrient status is inconsistent and has not received sufficient attention. This meta-analysis aimed to evaluate the effect of prepregnancy BMI on micronutrient levels in pregnant women. PubMed, Embase, Web of Scie...

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Autores principales:	Yan Yang, Zixin Cai, Jingjing Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ab59822d93d04a9c81dbfc7068bf962d
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spelling	oai:doaj.org-article:ab59822d93d04a9c81dbfc7068bf962d2021-12-02T17:25:33ZThe effect of prepregnancy body mass index on maternal micronutrient status: a meta-analysis10.1038/s41598-021-97635-32045-2322https://doaj.org/article/ab59822d93d04a9c81dbfc7068bf962d2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97635-3https://doaj.org/toc/2045-2322Abstract The relationship between prepregnancy body mass index (BMI) and maternal micronutrient status is inconsistent and has not received sufficient attention. This meta-analysis aimed to evaluate the effect of prepregnancy BMI on micronutrient levels in pregnant women. PubMed, Embase, Web of Science, and the Cochrane Library were searched for articles that contained information on micronutrient levels and prepregnancy BMI. A random-effects model was used to determine the association between prepregnancy BMI and maternal micronutrient status. Sixty-one eligible articles were eventually included, with 83,554 participants. Vitamin B12, folate, vitamin D, iron and ferritin were the main micronutrients evaluated in our meta-analysis. Prepregnancy obesity and overweight may lead to an increased risk of micronutrient deficiency, including vitamin B12, folate and vitamin D deficiency, while prepregnancy obesity or overweight may have no significant association with ferritin deficiency. Additionally, the results of the dose–response analyses demonstrated a possible significant inverse correlation between prepregnancy BMI and levels of micronutrient, except for iron and ferritin. Compared with women with normal weight, women who were overweight or obese prepregnancy have lower micronutrient concentrations and are more likely to exhibit micronutrient deficiency during pregnancy, which is harmful to both mothers and neonates.Yan YangZixin CaiJingjing ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yan Yang Zixin Cai Jingjing Zhang The effect of prepregnancy body mass index on maternal micronutrient status: a meta-analysis
description	Abstract The relationship between prepregnancy body mass index (BMI) and maternal micronutrient status is inconsistent and has not received sufficient attention. This meta-analysis aimed to evaluate the effect of prepregnancy BMI on micronutrient levels in pregnant women. PubMed, Embase, Web of Science, and the Cochrane Library were searched for articles that contained information on micronutrient levels and prepregnancy BMI. A random-effects model was used to determine the association between prepregnancy BMI and maternal micronutrient status. Sixty-one eligible articles were eventually included, with 83,554 participants. Vitamin B12, folate, vitamin D, iron and ferritin were the main micronutrients evaluated in our meta-analysis. Prepregnancy obesity and overweight may lead to an increased risk of micronutrient deficiency, including vitamin B12, folate and vitamin D deficiency, while prepregnancy obesity or overweight may have no significant association with ferritin deficiency. Additionally, the results of the dose–response analyses demonstrated a possible significant inverse correlation between prepregnancy BMI and levels of micronutrient, except for iron and ferritin. Compared with women with normal weight, women who were overweight or obese prepregnancy have lower micronutrient concentrations and are more likely to exhibit micronutrient deficiency during pregnancy, which is harmful to both mothers and neonates.
format	article
author	Yan Yang Zixin Cai Jingjing Zhang
author_facet	Yan Yang Zixin Cai Jingjing Zhang
author_sort	Yan Yang
title	The effect of prepregnancy body mass index on maternal micronutrient status: a meta-analysis
title_short	The effect of prepregnancy body mass index on maternal micronutrient status: a meta-analysis
title_full	The effect of prepregnancy body mass index on maternal micronutrient status: a meta-analysis
title_fullStr	The effect of prepregnancy body mass index on maternal micronutrient status: a meta-analysis
title_full_unstemmed	The effect of prepregnancy body mass index on maternal micronutrient status: a meta-analysis
title_sort	effect of prepregnancy body mass index on maternal micronutrient status: a meta-analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ab59822d93d04a9c81dbfc7068bf962d
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The effect of prepregnancy body mass index on maternal micronutrient status: a meta-analysis

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